Articles in press have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).
Chromosome 8 open reading frame 76 (C8orf76) co-expressed with cyclin-dependent kinase 4 (CDK4) as a prognostic indicator of colorectal cancer
Shang Guo, Chengcheng Liu, Zifeng Zhao, Zhongxin Li, Xia Jiang, Zengren Zhao
In press  doi: 10.3967/bes2024.177
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Objective  To explore the correlation between chromosome 8 open reading frame 76 (C8orf76) and cyclin-dependent kinase 4 (CDK4) and the potential predictive effect of C8orf76 and CDK4 on the prognosis of colorectal cancer (CRC).  Methods  We const...
Analysis of Tongue and Face Image Features of Anemic Women and Construction of Risk-Screening Model
Hongyuan Fu, Yi Chun, Yahan Zhang, Yu Wang, Yulin Shi, Tao Jiang, Xiaojuan Hu, Liping Tu, Yongzhi Li, Jiatuo Xu
In press  doi: 10.3967/bes2025.047
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Objective   To identify the key features of facial and tongue images associated with anemia in female populations, establish anemia risk-screening models, and evaluate their performance.  Methods   A total of 533 female participants (anemic and healt...
Association between ABO Blood Types and the Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study
Shuanghua Xie, Shuangying Li, Shaofei Su, Enjie Zhang, Shen Gao, Yue Zhang, Jianhui Liu, Minhui Hu, Ruixia Liu, Wentao Yue, Chenghong Yin
In press  doi: 10.3967/bes2025.046
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Objective  To investigate the association between ABO blood types and gestational diabetes mellitus (GDM) risk.  Methods  A prospective birth cohort study was conducted. ABO blood types were determined using the slide method. GDM diagnosis was based ...
Exploration of New Susceptible Genes Associated with Non-Alcoholic Fatty Liver Disease among Children with Obesity using Whole Exome Sequencing
Xiongfeng Pan, Cailian Wei, Jiayou Luo, Junxia Yan, Xiang Xiao, Jie Wang, Yan Zhong, Miyang Luo
In press  doi: 10.3967/bes2025.045
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Objective  This study aimed to evaluate the association between susceptibility genes and non-alcoholic fatty liver disease (NAFLD) in children with obesity.  Methods  We conducted a two-step case-control study. Ninety-three participants were subjecte...
Lumbar Spondylolysis in Chinese Adults: Prevalence and Musculoskeletal Condition
Dong Yan, Yandong Iiu, Ling Wang, Kai Li, Wenshuang Zhang, Yi Yuan, Jian Geng, Kangkang Ma, Fengyun Zhou, Zitong Cheng, Xiaoguang Cheng
In press  doi: 10.3967/bes2025.043
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Objective   To determine the prevalence of lumbar spondylolysis (LS) and the proportion of spondylolytic spondylolisthesis (SS) in China. To evaluate the musculoskeletal status of patients with LS and SS.  Methods   Spine Computed Tomography (CT) ima...
The Disease Burden of Asthma in China, 1990 to 2021 and Projections to 2050: Based on the Global Burden of Disease 2021
Ruiyi Zhang, Miaomiao Zhang, Yuchang Zhou, Jiahuan Guo, Xuankai Wang, Maigeng Zhou
In press  doi: 10.3967/bes2025.042
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Objective  Asthma imposes a significant global health burden. This study examines changes in the asthma-related disease burden from 1990 to 2021 and projects future burdens for 2050 under different scenarios.  Methods  Using data from the Global Burd...
Independent and Interactive Effects of Air Pollutants, Meteorological Factors, and Green Space on Tuberculosis Incidence in Shanghai
Qi Ye, Jing Chen, Yating Ji, Xiaoyu Lu, Jiale Deng, Nan Li, Wei Wei, Renjie Hou, Zhiyuan Li, Jianbang Xiang, Xu Gao, Xin Shen, Chongguang Yang
In press  doi: 10.3967/bes2025.041
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Objective  To assess the independent and combined effects of air pollutants, meteorological factors, and greenspace exposure on new tuberculosis (TB) cases.  Methods  TB case data from Shanghai (2013–2018) were obtained from the Shanghai Center for D...
Disease burden and trends of COPD in the Asia-Pacific region (1990–2019) and predictions to 2034
Jing Ma, Hong Mi
In press  doi: 10.3967/bes2025.040
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Objective  The Asia-Pacific region has a high Chronic obstructive pulmonary disease (COPD) burden, but studies on its trends are limited. Using the Global Burden of Disease (GBD) 2019 data, we analyzed COPD trends in 36 countries from 1990 to 2019 an...
Global Burden of Clostridium difficile Infection-Related Diarrhea Mortality from 1990 to 2021: A Study Based on the 2021 Global Burden of Disease Database
Ying Li, Jie Li, Hesheng Chang, Yuehua Hu, Chengdong Xu
In press  doi: 10.3967/bes2025.039
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Factors in Work-related Musculoskeletal Disorders in Dentists: A Structural Equation Model
Shunhang Li, Jian Li, Xin Xu, Yushan Huang, Yilin Zhang, Xiaoshuang Xu, Weizhen Guan, Xiaoping Liu, Jing Li
In press  doi: 10.3967/bes2025.037
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Forecast of the Burden of Lower Respiratory Infections in the Elderly Aged 70 and Above in China from 1990 to 2050, GBD2021
Miaomiao Zhang, Ruiyi Zhang, Yuchang Zhou, Maigeng Zhou
In press  doi: 10.3967/bes2025.036
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Objective  This study aims to analyze the burden of lower respiratory infections in Chinese elderly people aged 70 and above.  Methods  This study utilized Global Burden of Disease (GBD) 1990-2050 prediction data to analyze changes in mortality rates...
Perioperative Cardiac Arrest in Mechanically Ventilated Older Patients Undergoing Thoracic Surgery
Wenjun Liu, Shuyu Zhang, Sheng Wang
In press  doi: 10.3967/bes2025.035
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Future Projections of Temperature-related Excess Morbidity Due to Influenza Under Climate Change Scenarios: A Case Study in a Temperate Japanese City
Keita Wagatsuma
In press  doi: 10.3967/bes2025.034
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Deciphering the Role of VIM, STX8, and MIF in Pneumoconiosis Susceptibility: A Mendelian Randomization Analysis of the Lung-Gut Axis and Multi-Omics Insights from European and East Asian Populations
Chenwei Zhang, Binbin Wan, Yukai Zhang, Tao Xiong, Yishan Li, Xuesen Su, Gang Liu, Yangyang Wei, Yuanyuan Sun, Jingfen Zhang, Xiao Yu, Yiwei Shi
In press  doi: 10.3967/bes2025.028
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Background  Pneumoconiosis, a lung disease caused by irreversible fibrosis, represents a significant public health burden. This study investigates the causal relationships between gut microbiota, gene methylation, gene expression, protein levels, and...
Generalized Functional Linear Models: Efficient Modeling for High-dimensional Correlated Mixture Exposures
Bingsong Zhang, Haibin Yu, Xin Peng, Haiyi Yan, Siran Li, Shutong Luo, Renhuizi Wei, Zhujiang Zhou, Yalin Kuang, Yihuan Zheng, Chulan Ou, Linhua Liu, Yuehua Hu, Jindong Ni
In press  doi: 10.3967/bes2025.024
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Objective  Humans are exposed to complex mixtures of environmental chemicals and other factors that can affect their health. Analysis of these mixture exposures presents several key challenges for environmental epidemiology and risk assessment, inclu...
Association between Solid Cooking Fuel Use and Frailty Trajectories: Findings from a Nationwide Cohort in China
Yang Liu, Bingjie Wu, Bingbing Fan, Chunxia Li, Chang Su, Aidong Liu, Tao Zhang
In press  doi: 10.3967/bes2025.022
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Objective   Burning solid cooking fuel contributes to household air pollution and is associated with frailty. However, how solid cooking fuel use contributes to the development of frailty has not been well illustrated.  Methods   This study recruited...
Burden of Headache Disorders in China and its Provinces, 1990–2021
Zhe Liu, Xuehua Hu, Lin Yang, Jinlei Qi, Jiangmei Liu, Lijun Wang, Maigeng Zhou, Peng Yin
In press  doi: 10.3967/bes2025.019
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Objective  To analyze the prevalence and burden of headache disorders in China and its provinces from 1990 to 2021.  Methods  Using data from the Global Burden of Disease Study (GBD) 2021, the number of prevalent cases, prevalence rate, disability-ad...
Increased Tertiary Lymphoid Structures are Associated with Exaggerated Tissue Damage in the Lung of Smoker Patients with Pulmonary Tuberculosis
Yue Zhang, Liang Li, Zikang Sheng, Yafei Rao, Xiang Zhu, Yu Pang, Mengqiu Gao, Xiaoyan Gai, Yongchang Sun
In press  doi: 10.3967/bes2025.020
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Objective   Cigarette smoking exacerbates progression of pulmonary tuberculosis (TB) . The role of tertiary lymphoid structures (TLS) in chronic lung diseases has gained attention, but it remains unclear whether smoking-exacerbated lung damage in TB ...
Changes in Esophageal Cancer Survival: A Global Review of Survival Analysis from Cancer Registration Data over the Past three Decades
Zhuojun Ye, Danni Yang, Yu Jiang, Yuxuan Xiao, Zhuoying Li, Yuting Tan, Huiyun Yuan, Yongbing Xiang
In press  doi: 10.3967/bes2025.018
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Objective  To describe survival trends and global patterns of esophageal cancer (EC) using survival data from population-based cancer registries.  Methods  We systematically searched PubMed, EMBASE, Web of Science, SEER, and SinoMed databases for art...
Re-exploration for Dietary Iodine Intake in Chinese Adults Using the Obligatory Iodine Loss Hypothesis
Xiaobing Liu, Jun Wang, Yajie Li, Hongxing Tan, Deqian Mao, Yanyan Liu, Weidong Li, Wei Yu, Junan Yan, Jianhua Piao, Chongzheng Guo, Xiaoli Liu, Xiaoguang Yang
In press  doi: 10.3967/bes2025.017
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Objective  This study aimed to explore minimum iodine excretion and to build a dietary iodine recommendation for Chinese adults using the obligatory iodine loss hypothesis.  Methods  Data from 171 Chinese adults (19–21 years old) were collected and a...
Cover
2025-4 Cover
2025, 38(4).  
PDF 8811KB
2025-4 Contents
2025, 38(4): 1-2.  
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Editorial
Identification of High-Risk Populations: The Cornerstone of Effective and Cost-Efficient Cancer Screening
Wei Cao, Fei Wang, Ni Li
2025, 38(4): 401-402.   doi: 10.3967/bes2025.044
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Original Article
Role of Gold Nanorods Functionalized by Nucleic Acid Nanostructures Carrying Doxorubicin in Synergistic Anti-Cancer Therapy
Hao Wu, Huangshui Ma, Xinghan Wu, Qiang Sun, Lin Feng, Ruifang Jiang, Yanhong Li, Quan Shi
2025, 38(4): 403-415.   doi: 10.3967/bes2024.152
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Objective   Cancer remains a significant global health challenge, necessitating the development of effective treatment approaches. Developing synergistic therapy can provide a highly promising strategy for anti-cancer treatment through combining the...
Construction of a Prognostic Model for Lysosome-dependent Cell Death in Gastric Cancer Based on Single-cell RNA-seq and Bulk RNA-seq Data
Peng Ni, Kaixin Guo, Tianyi Liang, Xinshuang Fan, Yanqiao Hua, Yangye Gao, Shuaiyin Chen, Guangcai Duan, Rongguang Zhang
2025, 38(4): 416-432.   doi: 10.3967/bes2024.159
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Objective  To identify prognostic genes associated with lysosome-dependent cell death (LDCD) in patients with gastric cancer (GC).  Methods  Differentially expressed genes (DEGs) were identified using The Cancer Genome Atlas - Stomach Adenocarcino...
Threshold-Effect Associations of Serum 25-hydroxyvitamin D on Bone Turnover Markers and GC rs2282679 Variants in Chinese Women of Childbearing Age
Xiaoyun Shan, Yuting Li, Xiayu Zhao, Yichun Hu, Siran Li, Huidi Zhang, Yang Cao, Rui Wang, Lichen Yang
2025, 38(4): 433-446.   doi: 10.3967/bes2024.151
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Objective  This study aimed to investigate possible serum 25-hydroxyvitamin D [25(OH)D] cutoffs for the associations between 25(OH)D and Bone turnover markers (BTMs), and how GC gene variation influences such cutoffs in Chinese women of childbearing...
Exploring the Efficacy of BMSC Transplantation via Various Pathways for Treating Cholestatic Liver Fibrosis in Mice
Junjie Ren, Zixu Li, Xinrui Shi, Tingting Lyu, Xiaonan Li, Min Ge, Qizhi Shuai, Tingjuan Huang
2025, 38(4): 447-458.   doi: 10.3967/bes2024.180
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Objective  To compare the therapeutic efficacy of portal and tail vein transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) against cholestatic liver fibrosis in mice.   Methods  BMSCs were isolated and co-cultured with starvation...
Homocysteine Levels and Determinants among Chinese Women at Mid-pregnancy, Late Pregnancy, and Postpartum
Zhenyu Guo, Hongtian Li, Yirui Ma, Ying Meng, Yubo Zhou, Jianmeng Liu
2025, 38(4): 459-468.   doi: 10.3967/bes2024.155
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Objective   Data on homocysteine (Hcy) status and its determinants are limited among women during pregnancy and postpartum. This cross-sectional study aimed to investigate Hcy levels during pregnancy and postpartum, and to explore the determinants l...
Antibiotic-Depleted Lung Microbiota Modulates Surfactant Proteins Expression and Reduces Experimental Silicosis
Qiang Zhou, Meiyu Chang, Ning Li, Yi Guan, Sanqiao Yao
2025, 38(4): 469-483.   doi: 10.3967/bes2025.012
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Objective   Recent studies have overturned the traditional concept of the lung as a “sterile organ” revealing that pulmonary microbiota dysbiosis and abnormal surfactant proteins (SPs) expression are involved in the progression of silicosis. This st...
Hydrogen Sulfide Alleviates Lipid Peroxidation-Mediated Carbonyl Stress in Uranium-Intoxicated Kidney Cells via Nrf2/ARE Signaling
Jialin Liu, Min Wang, Rui Zhang, Jifang Zheng, Xixiu Jiang, Qiaoni Hu
2025, 38(4): 484-500.   doi: 10.3967/bes2025.021
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Objective  To explore the protective effects and underlying mechanisms of H2S against lipid peroxidation-mediated carbonyl stress in the uranium-treated NRK-52E cells.  Methods  Cell viability was evaluated using CCK-8 assay. Apoptosis was measure...
Letter
Development and Validation of Machine Learning Models for Lung Cancer Risk Prediction in High-Risk Population: A Retrospective Cohort Study
Yu Su, Haoran Zhan, Shangyao Li, Yitong Lu, Ruhuan Ma, Hai Fang, Tingting Xu, Yu Tian
2025, 38(4): 501-505.   doi: 10.3967/bes2025.038
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Risk Factors and Predictive Model for Acute Mountain Sickness among Han Chinese Travelers to Xizang Autonomous Region
Qianhui Gong, Qiong Li, Zhichao Xu, Xiaowei Chen, Xiaobing Shen
2025, 38(4): 506-510.   doi: 10.3967/bes2025.030
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Kitchen Ventilation Attenuate the Association of Solid Fuel Use with Sarcopenia: A Cross-Sectional and Prospective Study
Yinghao Yuchi, Wei Liao, Jia Qiu, Ruiying Li, Ning Kang, Xiaotian Liu, Wenqian Huo, Zhenxing Mao, Jian Hou, Lei Zhang, Chongjian Wang
2025, 38(4): 511-515.   doi: 10.3967/bes2025.031
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Experimental Study on Distribution and Deposition Characteristics of Phi-X174 and MS2 Bacteriophages in an Air Chamber
Baoying Zhang, Cuicui Ma, Yanyan Wang, Jin Shen
2025, 38(4): 516-518.   doi: 10.3967/bes2025.032
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Role of the Gut–Brain Axis in Chronotype-Driven Alzheimer’s Disease: A Mendelian Randomization Study
Jingting Kong, Mengxue Wang, Xuezi Zhang, Zan Wang, Qingguo Ren
2025, 38(4): 519-524.   doi: 10.3967/bes2025.033
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Bone Injury and Fracture Healing Biology
Ahmad Oryan, Somayeh Monazzah, Amin Bigham-Sadegh
2015, 28(1): 57-71.   doi: 10.3967/bes2015.006
[Abstract](12085) [PDF 3875KB](5156)
Report on Cardiovascular Health and Diseases in China 2021: An Updated Summary
The Writing Committee of the Report on Cardiovascular Health and Diseases in China
2022, 35(7): 573-603.   doi: 10.3967/bes2022.079
[Abstract](15503) [FullText HTML](7268) [PDF 2336KB](7268)
The Serum Exosome Derived MicroRNA-135a, -193b, and-384 Were Potential Alzheimer's Disease Biomarkers
YANG Ting Ting, LIU Chen Geng, GAO Shi Chao, ZHANG Yi, WANG Pei Chang
2018, 31(2): 87-96.   doi: 10.3967/bes2018.011
[Abstract](8614) [FullText HTML](3006) [PDF 11333KB](3006)
Burden of Cirrhosis and Other Chronic Liver Diseases Caused by Specific Etiologies in China, 1990−2016: Findings from the Global Burden of Disease Study 2016
LI Man, WANG Zhuo Qun, ZHANG Lu, ZHENG Hao, LIU Dian Wu, ZHOU Mai Geng
2020, 33(1): 1-10.   doi: 10.3967/bes2020.001
[Abstract](9489) [FullText HTML](3466) [PDF 2552KB](3466)
Report on Cardiovascular Health and Diseases in China 2022: an Updated Summary
The Writing Committee of the Report on Cardiovascular Health and Diseases in China
2023, 36(8): 669-701.   doi: 10.3967/bes2023.106
[Abstract](7816) [FullText HTML](3657) [PDF 1561KB](3657)
Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province, China
MAO Gen Xiang, LAN Xiao Guang, CAO Yong Bao, CHEN Zhuo Mei, HE Zhi Hua, LV Yuan Dong, WANG Ya Zhen, HU Xi Lian, WANG Guo Fu, YAN Jing
2012, 25(3): 317-324.   doi: 10.3967/0895-3988.2012.03.010
[Abstract](6380) [PDF 528KB](2672)
Trends in Lipids Level and Dyslipidemia among Chinese Adults, 2002-2015
SONG Peng Kun, MAN Qing Qing, LI Hong, PANG Shao Jie, JIA Shan Shan, LI Yu Qian, HE Li, ZHAO Wen Hua, ZHANG Jian
2019, 32(8): 559-570.   doi: 10.3967/bes2019.074
[Abstract](7485) [FullText HTML](2726) [PDF 3641KB](2726)
Protein Requirements in Healthy Adults:A Meta-analysis of Nitrogen Balance Studies
LI Min, SUN Feng, PIAO Jian Hua, YANG Xiao Guang
2014, 27(8): 606-613.   doi: 10.3967/bes2014.093
[Abstract](4915) [PDF 8784KB](1942)
Stability of SARS Coronavirus in Human Specimens and Environment and Its Sensitivity to Heating and UV Irradiation
SHU-MING DUAN, Xin-sheng Zhao, RUI-FU WEN, JING-JING HUANG, GUO-HUA PI, SU-XIANG ZHANG, JUN HAN, SHENG-LI BI, LI RUAN, XIAO-PING DONG, SARS RESEARCH TEAM
2003, 16(3): 246-255.  
[Abstract](7333) [PDF 610KB](1856)
Evidence on Invasion of Blood, Adipose Tissues, Nervous System and Reproductive System of Mice After a Single Oral Exposure: Nanoplastics versus Microplastics
YANG Zuo Sen, BAI Ying Long, JIN Cui Hong, NA Jun, ZHANG Rui, GAO Yuan, PAN Guo Wei, YAN Ling Jun, SUN Wei
2022, 35(11): 1025-1037.   doi: 10.3967/bes2022.131
[Abstract](3463) [FullText HTML](1613) [PDF 10064KB](1613)
TaqMan Real-time RT-PCR Assay for Detecting and Differentiating Japanese Encephalitis Virus
SHAO Nan, LI Fan, NIE Kai, FU Shi Hong, ZHANG Wei Jia, HE Ying, LEI Wen Wen, WANG Qian Ying, LIANG Guo Dong, CAO Yu Xi, WANG Huan Yu
2018, 31(3): 208-214.   doi: 10.3967/bes2018.026
[Abstract](4979) [FullText HTML](1941) [PDF 4691KB](1941)
Metabolomic Profiling Differences among Asthma, COPD, and Healthy Subjects: A LC-MS-based Metabolomic Analysis
LIANG Ying, GAI Xiao Yan, CHANG Chun, ZHANG Xu, WANG Juan, LI Ting Ting
2019, 32(9): 659-672.   doi: 10.3967/bes2019.085
[Abstract](5433) [FullText HTML](1678) [PDF 2914KB](1678)
Application of Nanopore Sequencing Technology in the Clinical Diagnosis of Infectious Diseases
ZHANG Lu Lu, ZHANG Chi, PENG Jun Ping
2022, 35(5): 381-392.   doi: 10.3967/bes2022.054
[Abstract](3500) [FullText HTML](1795) [PDF 2174KB](1795)
Evaluating the Nutritional Status of Oncology Patientsand Its Association with Quality of Life
ZHANG Ya Hui, XIE Fang Yi, CHEN Ya Wen, WANG Hai Xia, TIAN Wen Xia, SUN Wen Guang, WU Jing
2018, 31(9): 637-644.   doi: 10.3967/bes2018.088
[Abstract](6077) [FullText HTML](1832) [PDF 31943KB](1832)
Health Effect of Forest Bathing Trip on Elderly Patients with Chronic Obstructive Pulmonary Disease
JIA Bing Bing, YANG Zhou Xin, MAO Gen Xiang, LYU Yuan Dong, WEN Xiao Lin, XU Wei Hong, LYU XIAO Ling
2016, 29(3): 212-218.   doi: 10.3967/bes2016.026
[Abstract](3060) [PDF 803KB](1205)
The Emergence, Epidemiology, and Etiology of Haff Disease
PEI Pei, LI Xiao Yan, LU Shuang Shuang, LIU Zhe, WANG Rui, LU Xuan Cheng, LU Kai
2019, 32(10): 769-778.   doi: 10.3967/bes2019.096
[Abstract](5258) [FullText HTML](2233) [PDF 2249KB](2233)
Correlation between Anxiety, Depression, and Sleep Quality in College Students
ZHANG Yu Tong, HUANG Tao, ZHOU Fang, HUANG Ao Di, JI Xiao Qi, HE Lu, GENG Qiang, WANG Jia, MEI Can, XU Yu Jia, YANG Ze Long, ZHAN Jian Bo, CHENG Jing
2022, 35(7): 648-651.   doi: 10.3967/bes2022.084
[Abstract](3058) [FullText HTML](1385) [PDF 1202KB](1385)
Supplementation of Fermented Barley Extracts with Lactobacillus Plantarum dy-1 Inhibits Obesity via a UCP1-dependent Mechanism
XIAO Xiang, BAI Juan, LI Ming Song, ZHANG Jia Yan, SUN Xin Juan, DONG Ying
2019, 32(8): 578-591.   doi: 10.3967/bes2019.076
[Abstract](5271) [FullText HTML](1403) [PDF 9101KB](1403)
Mutual Impact of Diabetes Mellitus and Tuberculosis in China
CHENG Jun, ZHANG Hui, ZHAO Yan Lin, WANG Li Xia, CHEN Ming Ting
2017, 30(5): 384-389.   doi: 10.3967/bes2017.051
[Abstract](4502) [FullText HTML](1616) [PDF 671KB](1616)
Hypertension Prevalence, Awareness, Treatment, and Control and Their Associated Socioeconomic Factors in China: A Spatial Analysis of A National Representative Survey
WANG Wei, ZHANG Mei, XU Cheng Dong, YE Peng Peng, LIU Yun Ning, HUANG Zheng Jing, HU Cai Hong, ZHANG Xiao, ZHAO Zhen Ping, LI Chun, CHEN Xiao Rong, WANG Li Min, ZHOU Mai Geng
2021, 34(12): 937-951.   doi: 10.3967/bes2021.130
[Abstract](3749) [FullText HTML](1828) [PDF 2205KB](1828)

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Vol 38, No 4

(April, 2025)

ISSN 0895-3988

CN 11-2816/Q

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