Tuberculosis Control Priorities Defined by Using Cost-Effectiveness and Burden of Disease

XU Qun; WU Zheng-lai; JIN SHUI-GAO; ZHANG LiX-ing

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Volume 15 Issue 2

Jun. 2002

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Article Navigation > Biomedical and Environmental Sciences > 2002 > 15(2): 172-176

XU Qun, WU Zheng-lai, JIN SHUI-GAO, ZHANG LiX-ing. Tuberculosis Control Priorities Defined by Using Cost-Effectiveness and Burden of Disease[J]. Biomedical and Environmental Sciences, 2002, 15(2): 172-176.

Citation:

XU Qun, WU Zheng-lai, JIN SHUI-GAO, ZHANG LiX-ing. Tuberculosis Control Priorities Defined by Using Cost-Effectiveness and Burden of Disease[J]. Biomedical and Environmental Sciences, 2002, 15(2): 172-176.

Tuberculosis Control Priorities Defined by Using Cost-Effectiveness and Burden of Disease

Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy ofMedical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China
Information Center for Public Health, Chinese Academy of Preventive Medicine, Beijing 100050, China
Beijing ResearchInstitute for TB Control, Beijing 100035, China

Abstract

Objective To define TB control priorities using cost-effectiveness and burden of disease. Methods An assumed cohort of 2 000 cases was set up based on age-specific incidence of 794 newly registered smear-positive cases in Beijing in 1994. Prognostic trees and model diagrams of infectivity with natural history and DOTS intervention were constructed based on the epidemiological parameters. Results DOTS reduced 89.19 % of YLL, 78.90% of YLD, and 99.98% of infectivity BOD. One DALY could be saved with 45.70 Yuan by DOTS with 3% discount. Sensitivity analysis showed that discount had effect on CER. Weight of age was insensitive to CER. The higher the DOTS cured rate, the more the cost-effectiveness. Conclusions DOTS is a good cost-effectiveness TB control strategy. Cost-effectiveness and burden of disease can be used to define TB control priorities.
- Tuberculosis (TB),
- Burden of disease (BOD),
- Disability adjusted life year (DALY),
- Cost-effectiveness ratio (CER)
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Tuberculosis Control Priorities Defined by Using Cost-Effectiveness and Burden of Disease

Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy ofMedical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China

Information Center for Public Health, Chinese Academy of Preventive Medicine, Beijing 100050, China

Beijing ResearchInstitute for TB Control, Beijing 100035, China

Key words:

Abstract: Objective To define TB control priorities using cost-effectiveness and burden of disease. Methods An assumed cohort of 2 000 cases was set up based on age-specific incidence of 794 newly registered smear-positive cases in Beijing in 1994. Prognostic trees and model diagrams of infectivity with natural history and DOTS intervention were constructed based on the epidemiological parameters. Results DOTS reduced 89.19 % of YLL, 78.90% of YLD, and 99.98% of infectivity BOD. One DALY could be saved with 45.70 Yuan by DOTS with 3% discount. Sensitivity analysis showed that discount had effect on CER. Weight of age was insensitive to CER. The higher the DOTS cured rate, the more the cost-effectiveness. Conclusions DOTS is a good cost-effectiveness TB control strategy. Cost-effectiveness and burden of disease can be used to define TB control priorities.

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