| [1] | Zhu Q, Glazier BJ, Hinkel BC, et al. Neuroendocrine regulation of energy metabolism involving different types of adipose tissues. Int J Mol Sci, 2019; 20, 2707. doi: 10.3390/ijms20112707 |
| [2] | Giralt M, Villarroya F. White, brown, beige/brite: different adipose cells for different functions? Endocrinology, 2013; 154, 2992−3000. doi: 10.1210/en.2013-1403 |
| [3] | Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev, 2004; 84, 277−359. doi: 10.1152/physrev.00015.2003 |
| [4] | Hussain MF, Roesler A, Kazak L. Regulation of adipocyte thermogenesis: mechanisms controlling obesity. FEBS J, 2020. |
| [5] | Wankhade UD, Shen M, Yadav H, et al. Novel browning agents, mechanisms, and therapeutic potentials of brown adipose tissue. Biomed Res Int, 2016; 2016, 2365609. |
| [6] | Lee K, Lee YJ, Kim KJ, et al. Gomisin N from Schisandra chinensis ameliorates lipid accumulation and induces a brown fat-like phenotype through AMP-activated protein kinase in 3T3-L1 adipocytes. Int J Mol Sci, 2020; 21, 2153. doi: 10.3390/ijms21062153 |
| [7] | Czech MP. Mechanisms of insulin resistance related to white, beige, and brown adipocytes. Mol Metab, 2020; 34, 27−42. doi: 10.1016/j.molmet.2019.12.014 |
| [8] | Zhang J, Wu H, Ma S, et al. Transcription regulators and hormones involved in the development of brown fat and white fat browning: transcriptional and hormonal control of brown/beige fat development. Physiol Res, 2018; 67, 347−62. |
| [9] | Tu WZ, Fu YB, Xie X. RepSox, a small molecule inhibitor of the TGFbeta receptor, induces brown adipogenesis and browning of white adipocytes. Acta Pharmacol Sin, 2019; 40, 1523−31. doi: 10.1038/s41401-019-0264-2 |
| [10] | Shuai L, Zhang LN, Li BH, et al. SIRT5 regulates brown adipocyte differentiation and browning of subcutaneous white adipose tissue. Diabetes, 2019; 68, 1449−61. doi: 10.2337/db18-1103 |
| [11] | Klepac K, Yang J, Hildebrand S, et al. RGS2: a multifunctional signaling hub that balances brown adipose tissue function and differentiation. Mol Metab, 2019; 30, 173−83. doi: 10.1016/j.molmet.2019.09.015 |
| [12] | Cantwell MT, Farrar JS, Lownik JC, et al. STAT3 suppresses Wnt/beta-catenin signaling during the induction phase of primary Myf5+ brown adipogenesis. Cytokine, 2018; 111, 434−44. doi: 10.1016/j.cyto.2018.05.023 |
| [13] | Kawabe Y, Mori J, Morimoto H, et al. ACE2 exerts anti-obesity effect via stimulating brown adipose tissue and induction of browning in white adipose tissue. Am J Physiol Endocrinol Metab, 2019; 317, E1140−9. doi: 10.1152/ajpendo.00311.2019 |
| [14] | Liang Q, Zheng Q, Zuo Y, et al. SENP2 suppresses necdin expression to promote brown adipocyte differentiation. Cell Rep, 2019; 28, 2004−11. doi: 10.1016/j.celrep.2019.07.083 |
| [15] | Zhao H, Yao P, Fu N, et al. deSUMOylation signaling: a novel mechanism of liver CSC properties and hepatocarcinogenesis in hypoxia. Acta Biochim Biophys Sin (Shanghai), 2017; 49, 1135−7. doi: 10.1093/abbs/gmx109 |
| [16] | Zhao X. SUMO-mediated regulation of nuclear functions and signaling processes. Mol Cell, 2018; 71, 409−18. doi: 10.1016/j.molcel.2018.07.027 |
| [17] | Yamashita D, Yamaguchi T, Shimizu M, et al. The transactivating function of peroxisome proliferator-activated receptor gamma is negatively regulated by SUMO conjugation in the amino-terminal domain. Genes Cells, 2004; 9, 1017−29. doi: 10.1111/j.1365-2443.2004.00786.x |
| [18] | Hartig SM, Bader DA, Abadie KV, et al. Ubc9 impairs activation of the brown fat energy metabolism program in human white adipocytes. Mol Endocrinol, 2015; 29, 1320−33. doi: 10.1210/me.2015-1084 |
| [19] | Koh EH, Chen Y, Bader DA, et al. Mitochondrial activity in human white adipocytes is regulated by the ubiquitin carrier protein 9/microRNA-30a axis. J Biol Chem, 2016; 291, 24747−55. doi: 10.1074/jbc.M116.749408 |
| [20] | Liu LB, Omata W, Kojima I, et al. The SUMO conjugating enzyme Ubc9 is a regulator of GLUT4 turnover and targeting to the insulin-responsive storage compartment in 3T3-L1 adipocytes. Diabetes, 2007; 56, 1977−85. doi: 10.2337/db06-1100 |
| [21] | Chen Q, Huang L, Pan D, et al. Cbx4 sumoylates prdm16 to regulate adipose tissue thermogenesis. Cell Rep, 2018; 22, 2860−72. doi: 10.1016/j.celrep.2018.02.057 |
| [22] | Mukhopadhyay D, Dasso M. Modification in reverse: the SUMO proteases. Trends Biochem Sci, 2007; 32, 286−95. doi: 10.1016/j.tibs.2007.05.002 |
| [23] | Huang CJ, Wu D, Khan FA, et al. DeSUMOylation: An Important Therapeutic Target and Protein Regulatory Event. DNA Cell Biol, 2015; 34, 652−60. doi: 10.1089/dna.2015.2933 |
| [24] | Kumar A, Zhang KY. Advances in the development of SUMO specific protease (SENP) inhibitors. Comput Struct Biotechnol J, 2015; 13, 204−11. doi: 10.1016/j.csbj.2015.03.001 |
| [25] | Chung SS, Ahn BY, Kim M, et al. Control of adipogenesis by the SUMO-specific protease SENP2. Mol Cell Biol, 2010; 30, 2135−46. doi: 10.1128/MCB.00852-09 |
| [26] | Mitani T, Watanabe S, Yoshioka Y, et al. Theobromine suppresses adipogenesis through enhancement of CCAAT-enhancer-binding protein beta degradation by adenosine receptor A1. Biochim Biophys Acta Mol Cell Res, 2017; 1864, 2438−48. doi: 10.1016/j.bbamcr.2017.09.017 |
| [27] | Zheng Q, Cao Y, Chen Y, et al. Senp2 regulates adipose lipid storage by de-SUMOylation of Setdb1. J Mol Cell Biol, 2018; 10, 258−66. doi: 10.1093/jmcb/mjx055 |
| [28] | Cypess AM, Zhang H, Schulz TJ, et al. Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways. Endocrinology, 2011; 152, 3680−9. doi: 10.1210/en.2011-1229 |
| [29] | Hatting M, Rines AK, Luo C, et al. Adipose tissue CLK2 promotes energy expenditure during high-fat diet intermittent fasting. Cell Metab, 2017; 25, 428−37. doi: 10.1016/j.cmet.2016.12.007 |
| [30] | Fujimoto I, Hasegawa K, Fujiwara K, et al. Necdin controls EGFR signaling linked to astrocyte differentiation in primary cortical progenitor cells. Cell Signal, 2016; 28, 94−107. doi: 10.1016/j.cellsig.2015.11.016 |
| [31] | Tseng YH, Butte AJ, Kokkotou E, et al. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol, 2005; 7, 601−11. doi: 10.1038/ncb1259 |
| [32] | Qi Y, Zuo Y, Yeh ET, et al. An essential role of small ubiquitin-like modifier (SUMO)-specific protease 2 in myostatin expression and myogenesis. J Biol Chem, 2014; 289, 3288−93. doi: 10.1074/jbc.M113.518282 |
| [33] | Heymsfield SB, Greenberg AS, Fujioka K, et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA, 1999; 282, 1568−75. doi: 10.1001/jama.282.16.1568 |
| [34] | Koo YD, Lee JS, Lee SA, et al. SUMO-specific protease 2 mediates leptin-induced fatty acid oxidation in skeletal muscle. Metabolism, 2019; 95, 27−35. doi: 10.1016/j.metabol.2019.03.004 |
| [35] | Varjosalo M, Taipale J. Hedgehog: functions and mechanisms. Genes Dev, 2008; 22, 2454−72. doi: 10.1101/gad.1693608 |
| [36] | Suh JM, Gao X, McKay J, et al. Hedgehog signaling plays a conserved role in inhibiting fat formation. Cell Metab, 2006; 3, 25−34. doi: 10.1016/j.cmet.2005.11.012 |
| [37] | Lee HJ, Jo SB, Romer AI, et al. Overweight in mice and enhanced adipogenesis in vitro are associated with lack of the hedgehog coreceptor boc. Diabetes, 2015; 64, 2092−103. doi: 10.2337/db14-1017 |
| [38] | Wang J, Ge J, Cao H, et al. Leptin promotes white adipocyte browning by inhibiting the Hh signaling pathway. Cells, 2019; 8, 372. doi: 10.3390/cells8040372 |
| [39] | Koo YD, Choi JW, Kim M, et al. SUMO-specific rotease 2 (SENP2) is an important regulator of fatty acid metabolism in skeletal muscle. Diabetes, 2015; 64, 2420−31. doi: 10.2337/db15-0115 |
| [40] | Petrighi P, Lomax MA, Docherty K. Palmitate enhances the differentiation of mouse embryonic stem cells towards white adipocyte lineages. Mol Cell Endocrinol, 2012; 361, 40−50. doi: 10.1016/j.mce.2012.03.010 |