An Association of Elevated Serum Prolactin with Phthalate Exposure in Adult Men

LI ShuGuang; DAI JiCan; ZHANG LiQian; ZHANG Jing; ZHANG ZiQiang; CHEN Bo

doi:10.3967/0895-3988.2011.01.004

PDF
Cite
Share

facebook

twitter

google

linkedin

Volume 24 Issue 1

Feb. 2011

Turn off MathJax

Article Contents

Article Navigation > Biomedical and Environmental Sciences > 2011 > 24(1): 31-39

LI ShuGuang, DAI JiCan, ZHANG LiQian, ZHANG Jing, ZHANG ZiQiang, CHEN Bo. An Association of Elevated Serum Prolactin with Phthalate Exposure in Adult Men[J]. Biomedical and Environmental Sciences, 2011, 24(1): 31-39. doi: 10.3967/0895-3988.2011.01.004

Citation:

LI ShuGuang, DAI JiCan, ZHANG LiQian, ZHANG Jing, ZHANG ZiQiang, CHEN Bo. An Association of Elevated Serum Prolactin with Phthalate Exposure in Adult Men[J]. Biomedical and Environmental Sciences, 2011, 24(1): 31-39. doi: 10.3967/0895-3988.2011.01.004

An Association of Elevated Serum Prolactin with Phthalate Exposure in Adult Men

doi: 10.3967/0895-3988.2011.01.004

School of Public Health, Fudan University, Shanghai 200032, China
Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China
Tongji University Medical School, Shanghai 200092, China

Funds: the Shanghai Municipal Health Bureau(08GWQ003)%the Shanghai Population and Family Planning Commission(2007JG05)

Abstract

Objective To investigate the associations of hormone circulation with phthalate exposure in adult men.Methods Semen and serum samples were collected from 118 men who were suspected of infertility.Phthalate diesters including dibutyl phthalate (DBP) and diethylhexyl phthalate (DEHP) in both semen and serum samples were measured, along with serum levels of follicle stimulating hormone (FSH),luteinizing hormone (LH), testosterone (T), estradiol (E2) and prolactin (PRL).Results Serum PRL was positively associated with serum DBP and DEHP and semen DEHP in all models of Spearman correlation, linear regression and binary logistic regression. In linear regression models adjusted for potential confounders and excluding subjects with undetectable phthalates, a 10-fold increase in semen DEHP was associated with a 23% increase in serum PRL, as well as a 26% increase in serum DBP and a 20% increase in serum DEHP. In logistic regression models all subjects demonstrated a dose-response relationship between above reference value PRL and semen DEHP (odds ratio per tertile adjusted for potential confounders = 1.0, 1.70, 3.50; Pfor trend = 0.01), and serum DBP (1.0, 1.10, 2.62;P for trend = 0.04), and serum DEHP (1.0, 1.46, 4.69; P for trend ＜ 0.01). A positive correlation between serum estradiol and semen DEHP (linear regression), and an inverse correlation between semen DBP and serum testosterone and T:E2 ratio (Spearman correlation) were also established.Conclusions Serum PRL is suggested to be positively associated with both DBP and DEHP exposure in adult men.
- Phthalate diesters,
- Prolactin,
- Testosterone,
- Estradiol,
- Male reproduction
References
Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views(1372) PDF downloads(92) Cited by()

Proportional views

An Association of Elevated Serum Prolactin with Phthalate Exposure in Adult Men

doi: 10.3967/0895-3988.2011.01.004

School of Public Health, Fudan University, Shanghai 200032, China

Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China

Tongji University Medical School, Shanghai 200092, China

Funds: the Shanghai Municipal Health Bureau(08GWQ003)%the Shanghai Population and Family Planning Commission(2007JG05)

Key words:

Abstract: Objective To investigate the associations of hormone circulation with phthalate exposure in adult men.Methods Semen and serum samples were collected from 118 men who were suspected of infertility.Phthalate diesters including dibutyl phthalate (DBP) and diethylhexyl phthalate (DEHP) in both semen and serum samples were measured, along with serum levels of follicle stimulating hormone (FSH),luteinizing hormone (LH), testosterone (T), estradiol (E2) and prolactin (PRL).Results Serum PRL was positively associated with serum DBP and DEHP and semen DEHP in all models of Spearman correlation, linear regression and binary logistic regression. In linear regression models adjusted for potential confounders and excluding subjects with undetectable phthalates, a 10-fold increase in semen DEHP was associated with a 23% increase in serum PRL, as well as a 26% increase in serum DBP and a 20% increase in serum DEHP. In logistic regression models all subjects demonstrated a dose-response relationship between above reference value PRL and semen DEHP (odds ratio per tertile adjusted for potential confounders = 1.0, 1.70, 3.50; Pfor trend = 0.01), and serum DBP (1.0, 1.10, 2.62;P for trend = 0.04), and serum DEHP (1.0, 1.46, 4.69; P for trend ＜ 0.01). A positive correlation between serum estradiol and semen DEHP (linear regression), and an inverse correlation between semen DBP and serum testosterone and T:E2 ratio (Spearman correlation) were also established.Conclusions Serum PRL is suggested to be positively associated with both DBP and DEHP exposure in adult men.

Citation: