A Study on the Protective Effect of Cynodon dactylon Leaves Extract in Diabetic Rats

Key words: 
• Cynodon dactylon /
• Ethanolic extract /
• GC-MS /
• Alloxan diabetes /
• Antidiabetic /
• Antioxidant /
• Lipid profile /
• Enzyme profile

Abstract: Objective To investigate the antidiabetic, antioxidant and hypolipidemic efficacy of Cynodon dactylon in diabetic rats. Methods The experimental rats were randomly divided into three groups: Group Ⅰ: control; Group Ⅱ: Alloxan diabetic, untreated; and Group Ⅲ: Alloxan diabetic treated with ethanolic extract of C. dactylon leaves (450 mg/kg·bw). Experimental diabetes was induced by alloxan in a single dose of 150 mg/kg·bw. Results A Significant diminution of fasting blood sugar level was observed and also significant increase in HDL and decrease (P<0.05) in cholesterol, triglyceride, LDL and VLDL were observed after 15 days of treatment. The investigation also revealed, the activities of AST, ALT, ALP, AP, LDH, and CPK (P<0.05) were decreased in the extract-supplemented group. The significant decrease in protein content and SOD, CAT, GPx, and GSH (P<0.05) activity and increase in LPO in plasma were found to be ameliorated after treatment. Conclusion Our result supports the fact that administration of extract of C. dactylon leave is able to reduce hyperglycemia and hyperlipidemia risk and also reduced the oxidative stress in diabetic rats.