Meta-analysis of Cytochrome P4501A1 Mspl Gene Polymorphism and Childhood Acute Leukemia

ZHANG Yao Dong; TAN Li Na; ZHANG Xiao Ling; WEI Hal Yan; XIONG Hao; HU Qun

doi:10.3967/0895-3988.2011.06.014

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Volume 24 Issue 6

Dec. 2011

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Article Navigation > Biomedical and Environmental Sciences > 2011 > 24(6): 683-687

ZHANG Yao Dong, TAN Li Na, ZHANG Xiao Ling, WEI Hal Yan, XIONG Hao, HU Qun. Meta-analysis of Cytochrome P4501A1 Mspl Gene Polymorphism and Childhood Acute Leukemia[J]. Biomedical and Environmental Sciences, 2011, 24(6): 683-687. doi: 10.3967/0895-3988.2011.06.014

Citation:

ZHANG Yao Dong, TAN Li Na, ZHANG Xiao Ling, WEI Hal Yan, XIONG Hao, HU Qun. Meta-analysis of Cytochrome P4501A1 Mspl Gene Polymorphism and Childhood Acute Leukemia[J]. Biomedical and Environmental Sciences, 2011, 24(6): 683-687. doi: 10.3967/0895-3988.2011.06.014

Meta-analysis of Cytochrome P4501A1 Mspl Gene Polymorphism and Childhood Acute Leukemia

doi: 10.3967/0895-3988.2011.06.014

Department of Endocrinology, Zhengzhou Children＇s Hospital, Zhengzhou 450053, Henan, China
Department of Cardiothoracic Surgery, Zhengzhou Children's Hospital, Zhengzhou 450053, Henan, China
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China
Department of Hematology, Wuhan Children＇s Hospital, Wuhan 430016, Hubei, China

Abstract

Objective To investigate the relationship between cytochrome P4501A1 (CYP1A1) Msp I gene polymorphism and childhood acute leukemia (AL).Methods Relevant literature was extensively searched and screened by Pubmed and Wanfang Database,Chinese Science Journal Database and Chinese Journal Net.Various data consolidation,combined OR values and their 95％ Cl were tested by RevMan 4.2; Funnel plots were used for the bias analysis.Results Six related literatures were found to meet the requirements.According to heterogeneity results,there was no significant difference in homozygous types(P＞0.05),while there was significant difference in two others types (P all＜0.05).For wild CYP1A1Mspl homozygous for the reference group,Combined OR of heterozygous mutation,homozygous,heterozygous + homozygous mutation in AL and control groups were 1.18,0.96,and 1.10 respectively.Subgroup analysis:Z values of CYP1A1Mspl homozygous,heterozygous + homozygous in the acute lymphoblastic leukemia (ALL) and the control group were 0.10 and 0.76 respectively,Z values in non-acute lymphoblastic leukemia and control group were 0.74 and 0.75.Conclusion There is no correlation between CYP1A1Mspl gene polymorphism and the susceptibility of childhood AL.
- Acute leukemia,
- Cytochrome P4501A1,
- Genetic polymorphism,
- Meta-analysis
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Meta-analysis of Cytochrome P4501A1 Mspl Gene Polymorphism and Childhood Acute Leukemia

doi: 10.3967/0895-3988.2011.06.014

Department of Endocrinology, Zhengzhou Children＇s Hospital, Zhengzhou 450053, Henan, China

Department of Cardiothoracic Surgery, Zhengzhou Children's Hospital, Zhengzhou 450053, Henan, China

Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China

Department of Hematology, Wuhan Children＇s Hospital, Wuhan 430016, Hubei, China

Key words:

Abstract: Objective To investigate the relationship between cytochrome P4501A1 (CYP1A1) Msp I gene polymorphism and childhood acute leukemia (AL).Methods Relevant literature was extensively searched and screened by Pubmed and Wanfang Database,Chinese Science Journal Database and Chinese Journal Net.Various data consolidation,combined OR values and their 95％ Cl were tested by RevMan 4.2; Funnel plots were used for the bias analysis.Results Six related literatures were found to meet the requirements.According to heterogeneity results,there was no significant difference in homozygous types(P＞0.05),while there was significant difference in two others types (P all＜0.05).For wild CYP1A1Mspl homozygous for the reference group,Combined OR of heterozygous mutation,homozygous,heterozygous + homozygous mutation in AL and control groups were 1.18,0.96,and 1.10 respectively.Subgroup analysis:Z values of CYP1A1Mspl homozygous,heterozygous + homozygous in the acute lymphoblastic leukemia (ALL) and the control group were 0.10 and 0.76 respectively,Z values in non-acute lymphoblastic leukemia and control group were 0.74 and 0.75.Conclusion There is no correlation between CYP1A1Mspl gene polymorphism and the susceptibility of childhood AL.

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