Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese

ZHANG Ming Liang; HOU Xu Hong; ZHU Yun Xia; LU Jun Xi; PENG Liang Pu; GU Hui Lin; JIA Wei Ping

doi:10.3967/0895-3988.2012.01.006

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Volume 25 Issue 1

Feb. 2012

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Article Navigation > Biomedical and Environmental Sciences > 2012 > 25(1): 38-45

ZHANG Ming Liang, HOU Xu Hong, ZHU Yun Xia, LU Jun Xi, PENG Liang Pu, GU Hui Lin, JIA Wei Ping. Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese[J]. Biomedical and Environmental Sciences, 2012, 25(1): 38-45. doi: 10.3967/0895-3988.2012.01.006

Citation:

ZHANG Ming Liang, HOU Xu Hong, ZHU Yun Xia, LU Jun Xi, PENG Liang Pu, GU Hui Lin, JIA Wei Ping. Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese[J]. Biomedical and Environmental Sciences, 2012, 25(1): 38-45. doi: 10.3967/0895-3988.2012.01.006

Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese

doi: 10.3967/0895-3988.2012.01.006

Department of Endocrinology and Metabolism, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University; Shanghai Diabetes Institute; Shanghai Clinical Center of Diabetes; Shanghai Key Laboratory of Diabetes Mellitus, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China
Shanghai Caoyang Community Health Care Center, Shanghai 200062, China
Shanghai Huayang Community Health Care Center, Shanghai 200042, China

Funds: This research was supported by the Major Program of Shanghai Municipality for Basic Research(08dj1400601)%Shanghai Key Laboratory of Diabetes Mellitus(08DZ2230200)%by the Key Project of Science and Technology of Shanghai(09DZ1950202)

Abstract

Objective The association of metabolic syndrome (MetS) with cardiovascular diseases (CVD) has not been adequately explored in middle-aged and elderly Chinese.This study aimed to investigate MetS' prevalence and its impact on the CVD incidence in this specific population group.Methods A data set of a community-based prospective cohort study was analyzed.A total of 2300 subjects aged 40-94 years were followed up for the CVD events.MetS defined according to the JCDCG criteria was assessed at baseline,and the middle-aged and elderly groups were classified by the WHO definition.Results As compared with the middle-aged group,the prevalence of MetS increased by 0.6 times (34.6％ vs.21.3％) and the incidence density of CVD increased by 4.9 times in the elderly group (52.3/1000 person-year vs.8.9/1000 person-year).Furthermore,the multivariate Cox regression revealed that the risk to CVD incidence was independently related to increased waist circumference in the middle-aged group (HR=2.23,P＜0.01) and to elevated blood glucose in the elderly group (HR=1.39,P＜0.01).Conclusion MetS was highly prevalent in middle-aged and elderly Chinese.MetS significantly increased the risk to CVD incidence in the elderly.All individuals with metabolic disorders should receive active clinical care to reduce the incidence of CVD.
- Metabolic syndrome,
- Cardiovascular disease,
- The middle-aged,
- The elderly
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese

doi: 10.3967/0895-3988.2012.01.006

Department of Endocrinology and Metabolism, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University; Shanghai Diabetes Institute; Shanghai Clinical Center of Diabetes; Shanghai Key Laboratory of Diabetes Mellitus, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China

Shanghai Caoyang Community Health Care Center, Shanghai 200062, China

Shanghai Huayang Community Health Care Center, Shanghai 200042, China

Key words:

Abstract: Objective The association of metabolic syndrome (MetS) with cardiovascular diseases (CVD) has not been adequately explored in middle-aged and elderly Chinese.This study aimed to investigate MetS' prevalence and its impact on the CVD incidence in this specific population group.Methods A data set of a community-based prospective cohort study was analyzed.A total of 2300 subjects aged 40-94 years were followed up for the CVD events.MetS defined according to the JCDCG criteria was assessed at baseline,and the middle-aged and elderly groups were classified by the WHO definition.Results As compared with the middle-aged group,the prevalence of MetS increased by 0.6 times (34.6％ vs.21.3％) and the incidence density of CVD increased by 4.9 times in the elderly group (52.3/1000 person-year vs.8.9/1000 person-year).Furthermore,the multivariate Cox regression revealed that the risk to CVD incidence was independently related to increased waist circumference in the middle-aged group (HR=2.23,P＜0.01) and to elevated blood glucose in the elderly group (HR=1.39,P＜0.01).Conclusion MetS was highly prevalent in middle-aged and elderly Chinese.MetS significantly increased the risk to CVD incidence in the elderly.All individuals with metabolic disorders should receive active clinical care to reduce the incidence of CVD.

Citation:

ZHANG Ming Liang, HOU Xu Hong, ZHU Yun Xia, LU Jun Xi, PENG Liang Pu, GU Hui Lin, JIA Wei Ping. Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese[J]. Biomedical and Environmental Sciences, 2012, 25(1): 38-45. doi: 10.3967/0895-3988.2012.01.006