Volume 26 Issue 8
Aug.  2013
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XU Mei Mei, JIA Yu Ping, LI Guo Xing, LIU Li Qun, MO Yun Zheng, JIN Xiao Bin, PAN Xiao Chuan. Relationship between Ambient Fine Particles and Ventricular Repolarization Changes and Heart Rate Variability of Elderly People with Heart Disease in Beijing, China[J]. Biomedical and Environmental Sciences, 2013, 26(8): 629-637. doi: 10.3967/0895-3988.2013.08.001
Citation: XU Mei Mei, JIA Yu Ping, LI Guo Xing, LIU Li Qun, MO Yun Zheng, JIN Xiao Bin, PAN Xiao Chuan. Relationship between Ambient Fine Particles and Ventricular Repolarization Changes and Heart Rate Variability of Elderly People with Heart Disease in Beijing, China[J]. Biomedical and Environmental Sciences, 2013, 26(8): 629-637. doi: 10.3967/0895-3988.2013.08.001

Relationship between Ambient Fine Particles and Ventricular Repolarization Changes and Heart Rate Variability of Elderly People with Heart Disease in Beijing, China

doi: 10.3967/0895-3988.2013.08.001
Funds:  This study was supported by the National Natural Science Foundation of China (Grant 20637020)
  • Objective To explore the effects of particulate matters less than 2.5 μm in aerodynamic diameter (PM2.5) on heart repolarization/depolarization and heart rate variability (HRV). Methods We conducted a panel study for elderly subjects with heart disease in Beijing from 2007 to 2008. PM2.5 was measured at a fixed station for 20 h continuously each day while electrocardiogram (ECG) indexes of 42 subjects were also recorded repeatedly. Meteorological data was obtained from the China Meteorological Data Sharing Service System. A mixed linear regression model was used to estimate the associations between PM2.5 and the ECG indexes. The model was adjusted for age, body mass index, sex, day of the week and meteorology. Results Significant adverse effects of PM2.5 on ECG indexes reflecting HRV were observed statistically and the strongest effect of PM2.5 on HRV was on lag 1 day in our study. However, there were no associations between PM2.5 and ECG indexes reflecting heart repolarization/depolarization. Additionally, the effects of PM2.5 on subjects with hypertension were larger than on the subjects without hypertension. Conclusion This study showed ambient PM2.5 could affect cardiac autonomic function of the elderly people with heart disease, and subjects with hypertension appeared to be more susceptive to the autonomic dysfunction induced by PM2.5.
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Relationship between Ambient Fine Particles and Ventricular Repolarization Changes and Heart Rate Variability of Elderly People with Heart Disease in Beijing, China

doi: 10.3967/0895-3988.2013.08.001
Funds:  This study was supported by the National Natural Science Foundation of China (Grant 20637020)

Abstract: Objective To explore the effects of particulate matters less than 2.5 μm in aerodynamic diameter (PM2.5) on heart repolarization/depolarization and heart rate variability (HRV). Methods We conducted a panel study for elderly subjects with heart disease in Beijing from 2007 to 2008. PM2.5 was measured at a fixed station for 20 h continuously each day while electrocardiogram (ECG) indexes of 42 subjects were also recorded repeatedly. Meteorological data was obtained from the China Meteorological Data Sharing Service System. A mixed linear regression model was used to estimate the associations between PM2.5 and the ECG indexes. The model was adjusted for age, body mass index, sex, day of the week and meteorology. Results Significant adverse effects of PM2.5 on ECG indexes reflecting HRV were observed statistically and the strongest effect of PM2.5 on HRV was on lag 1 day in our study. However, there were no associations between PM2.5 and ECG indexes reflecting heart repolarization/depolarization. Additionally, the effects of PM2.5 on subjects with hypertension were larger than on the subjects without hypertension. Conclusion This study showed ambient PM2.5 could affect cardiac autonomic function of the elderly people with heart disease, and subjects with hypertension appeared to be more susceptive to the autonomic dysfunction induced by PM2.5.

XU Mei Mei, JIA Yu Ping, LI Guo Xing, LIU Li Qun, MO Yun Zheng, JIN Xiao Bin, PAN Xiao Chuan. Relationship between Ambient Fine Particles and Ventricular Repolarization Changes and Heart Rate Variability of Elderly People with Heart Disease in Beijing, China[J]. Biomedical and Environmental Sciences, 2013, 26(8): 629-637. doi: 10.3967/0895-3988.2013.08.001
Citation: XU Mei Mei, JIA Yu Ping, LI Guo Xing, LIU Li Qun, MO Yun Zheng, JIN Xiao Bin, PAN Xiao Chuan. Relationship between Ambient Fine Particles and Ventricular Repolarization Changes and Heart Rate Variability of Elderly People with Heart Disease in Beijing, China[J]. Biomedical and Environmental Sciences, 2013, 26(8): 629-637. doi: 10.3967/0895-3988.2013.08.001

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