An Estimation of the Daily Intake of Di (2-ethlhexyl) Phthalate (DEHP) among Workers in Flavoring Factories

LU Jie; ZHANG Jing; WANG Zhu Tian; FAN Yong Xiang

doi:10.3967/bes2014.071

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Volume 27 Issue 6

Jun. 2014

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Article Navigation > Biomedical and Environmental Sciences > 2014 > 27(6): 419-425

LU Jie, ZHANG Jing, WANG Zhu Tian, FAN Yong Xiang. An Estimation of the Daily Intake of Di (2-ethlhexyl) Phthalate (DEHP) among Workers in Flavoring Factories[J]. Biomedical and Environmental Sciences, 2014, 27(6): 419-425. doi: 10.3967/bes2014.071

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LU Jie, ZHANG Jing, WANG Zhu Tian, FAN Yong Xiang. An Estimation of the Daily Intake of Di (2-ethlhexyl) Phthalate (DEHP) among Workers in Flavoring Factories[J]. Biomedical and Environmental Sciences, 2014, 27(6): 419-425. doi: 10.3967/bes2014.071

An Estimation of the Daily Intake of Di (2-ethlhexyl) Phthalate (DEHP) among Workers in Flavoring Factories

doi: 10.3967/bes2014.071

Key Laboratory of Food Safety Risk Assessment, Ministry of Health, China National Center For Food Safety Risk Assessment, Beijing 100022, China
Division of Food Safety Standard, Ministry of Health, China National Center For food Safety Risk Assessment, Beijing 100022, China

Funds: This research was supported by the 12th five-year national science and technology support plan(2011BAK10B05-02)

Abstract

Objective To estimate the daily intake of DEHP among workers in flavoring factories.
Methods 71 workers in two flavoring manufacturers, 27 administrators in those factories and 31 laboratory technicians in a research institute were recruited and assigned to exposure group, control group 1 and control group 2 respectively. Their urinary DEHP metabolites, mono(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), were detected by isotope dilution-ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS). The urinary metabolites concentrations were converted into DEHP intake levels using two pharmacokinetic models: the urine creatinine-excretion (UCE) one and the urine volume (UV) one.
Results No significant differences were found among the three groups. Based on the urinary concentrations ofΣ3MEHP, we got a median daily DEHP intake of 3.22 or 1.85μg/kg body-weight/day applying the UV or UCE models respectively. Depending on the UV model, three subjects (2.34%) exceeded the RfD value given by US EPA and the P50 of estimate daily DEHP intakes accounted for 16.10%of the RfD value. No subjects exceeded the limitation depending on the UCE model.
Conclusion The workers in flavoring factories were not supposed to be the high DEHP exposure ones and their exposure level remained at a low risk.
- Di (2-ethylhexyl) phthalate (DEHP),
- Estimate daily intake,
- Biomonitoring,
- Occupational exposure
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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An Estimation of the Daily Intake of Di (2-ethlhexyl) Phthalate (DEHP) among Workers in Flavoring Factories

doi: 10.3967/bes2014.071

Key Laboratory of Food Safety Risk Assessment, Ministry of Health, China National Center For Food Safety Risk Assessment, Beijing 100022, China

Division of Food Safety Standard, Ministry of Health, China National Center For food Safety Risk Assessment, Beijing 100022, China

Funds: This research was supported by the 12th five-year national science and technology support plan(2011BAK10B05-02)

Key words:

Abstract: Objective To estimate the daily intake of DEHP among workers in flavoring factories.
Methods 71 workers in two flavoring manufacturers, 27 administrators in those factories and 31 laboratory technicians in a research institute were recruited and assigned to exposure group, control group 1 and control group 2 respectively. Their urinary DEHP metabolites, mono(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), were detected by isotope dilution-ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS). The urinary metabolites concentrations were converted into DEHP intake levels using two pharmacokinetic models: the urine creatinine-excretion (UCE) one and the urine volume (UV) one.
Results No significant differences were found among the three groups. Based on the urinary concentrations ofΣ3MEHP, we got a median daily DEHP intake of 3.22 or 1.85μg/kg body-weight/day applying the UV or UCE models respectively. Depending on the UV model, three subjects (2.34%) exceeded the RfD value given by US EPA and the P50 of estimate daily DEHP intakes accounted for 16.10%of the RfD value. No subjects exceeded the limitation depending on the UCE model.
Conclusion The workers in flavoring factories were not supposed to be the high DEHP exposure ones and their exposure level remained at a low risk.

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