A Centralized Report on Pediatric Japanese Encephalitis Cases from Beijing Children’s Hospital, 2013

LI Jiu Wei; GAO Xiao Yan; WU Yun; FU Shi Hong; TAN Xiao Juan; CAO Yu Xi; ZHANG Wei Hua; YIN Zun Dong; HE Ying; LI Yi Xing; LIANG Guo Dong; XU Wen Bo; FANG Fang; WANG Huan Yu

doi:10.3967/bes2016.121

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Volume 29 Issue 12

Dec. 2016

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Article Navigation > Biomedical and Environmental Sciences > 2016 > 29(12): 902-908

LI Jiu Wei, GAO Xiao Yan, WU Yun, FU Shi Hong, TAN Xiao Juan, CAO Yu Xi, ZHANG Wei Hua, YIN Zun Dong, HE Ying, LI Yi Xing, LIANG Guo Dong, XU Wen Bo, FANG Fang, WANG Huan Yu. A Centralized Report on Pediatric Japanese Encephalitis Cases from Beijing Children’s Hospital, 2013[J]. Biomedical and Environmental Sciences, 2016, 29(12): 902-908. doi: 10.3967/bes2016.121

Citation:

LI Jiu Wei, GAO Xiao Yan, WU Yun, FU Shi Hong, TAN Xiao Juan, CAO Yu Xi, ZHANG Wei Hua, YIN Zun Dong, HE Ying, LI Yi Xing, LIANG Guo Dong, XU Wen Bo, FANG Fang, WANG Huan Yu. A Centralized Report on Pediatric Japanese Encephalitis Cases from Beijing Children’s Hospital, 2013[J]. Biomedical and Environmental Sciences, 2016, 29(12): 902-908. doi: 10.3967/bes2016.121

A Centralized Report on Pediatric Japanese Encephalitis Cases from Beijing Children’s Hospital, 2013

doi: 10.3967/bes2016.121

Neurology Department, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China
Department of Viral Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Department of Polio, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
National Immunization Programme, Chinese Center for Disease Control and Prevention, Beijing 100050, China

Funds: grants from the National Key Research and Development Program(2016YFD0500401)%a clinical technological innovation project supervised by the Beijing Hospital Authority(XMLX201401)%a Development Grant of the State Key Laboratory of Infectious Disease Prevention and Control(2015SKLID505,2014SKLID03)%Ministry of Science and Technology of the People’s Republic of China(2013ZX10004202, 2013ZX10004101, 2012ZX10004215)%the National Natural Science Foundation of China(81290342 and 81501757)%the Special National Project on Research and Development of Key Biosafety Technologies(2016YFC1201900)

Abstract

Fifteen pediatric cases of suspected Japanese encephalitis (JE) were reported in Beijing Children’s Hospital during the late summer of 2013. The clinical manifestations in most cases included high fever, seizures, and abnormal magnetic resonance imaging findings. Twelve of 15 cases were laboratory-confirmed as JE cases by pathogen identification. Epidemiological investigations showed that five of the 12 laboratory-confirmed patients had an incomplete JE vaccination history. Follow-up investigations after discharge indicated that seven laboratory-confirmed JE patients without JE vaccinations had relatively poor prognoses, with an average Modified Rankin Scale (MRS) score of 2.6 when compared with the other five laboratory-confirmed, JE-vaccinated patients with an average MRS score of 0.5. The observation of pediatric JE cases among those with a history of JE vaccination warrants further attention.
- Japanese encephalitis,
- Pediatric,
- Prognoses
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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A Centralized Report on Pediatric Japanese Encephalitis Cases from Beijing Children’s Hospital, 2013

doi: 10.3967/bes2016.121

Neurology Department, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China

Department of Viral Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China

Department of Polio, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China

National Immunization Programme, Chinese Center for Disease Control and Prevention, Beijing 100050, China

Key words:

Abstract: Fifteen pediatric cases of suspected Japanese encephalitis (JE) were reported in Beijing Children’s Hospital during the late summer of 2013. The clinical manifestations in most cases included high fever, seizures, and abnormal magnetic resonance imaging findings. Twelve of 15 cases were laboratory-confirmed as JE cases by pathogen identification. Epidemiological investigations showed that five of the 12 laboratory-confirmed patients had an incomplete JE vaccination history. Follow-up investigations after discharge indicated that seven laboratory-confirmed JE patients without JE vaccinations had relatively poor prognoses, with an average Modified Rankin Scale (MRS) score of 2.6 when compared with the other five laboratory-confirmed, JE-vaccinated patients with an average MRS score of 0.5. The observation of pediatric JE cases among those with a history of JE vaccination warrants further attention.

Citation:

LI Jiu Wei, GAO Xiao Yan, WU Yun, FU Shi Hong, TAN Xiao Juan, CAO Yu Xi, ZHANG Wei Hua, YIN Zun Dong, HE Ying, LI Yi Xing, LIANG Guo Dong, XU Wen Bo, FANG Fang, WANG Huan Yu. A Centralized Report on Pediatric Japanese Encephalitis Cases from Beijing Children’s Hospital, 2013[J]. Biomedical and Environmental Sciences, 2016, 29(12): 902-908. doi: 10.3967/bes2016.121