DNA Damage Caused By Pesticide-contaminated Soil
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Key words:
- Carbaryl /
- Contaminated soil /
- DNA damage /
- FADU- Huorimetric analysis of DNA unwinding assay /
- Genotoxicity /
- α-Napthol and pesticide
Abstract: Objective To determine the DNA damaging potential and the genotoxicity of individual compounds in pesticide contaminated soil. Methods In the present study, DNA damaging potential of pesticide-contaminated soil and the genotoxicity of individual compounds present in the soil were assessed using fluorimetric analysis of DNA unwinding assay. Results The contaminated soil sample showed 79% (P<0.001) of DNA strand break, whereas technical grade of major carbaryl and α-naphthol constituents of the contaminated soil showed 64% (P<0.01) and 60% (P<0.02) damage respectively. Conclusion Our results indicate that the toxicity caused by contaminated soil is mainly due to carbaryl and α -napthol, which are the major constituents of the soil sample analyzed by GC-MS.
Citation: | K.KRISHNAMURTHI, S. SARAVANA DEVI, T. CHAKRABARTI. DNA Damage Caused By Pesticide-contaminated Soil[J]. Biomedical and Environmental Sciences, 2006, 19(6): 427-431. |