The First Chinese Case of Creutzfeldt-Jakob Disease with Mutation of E200K in PRNP
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Key words:
- CJD /
- PRNP /
- Sleep disturbance /
- 14-3-3
Abstract: Objective To investigate epidemiological, clinical and genetic features of the first Chinese case of Creutzfeldt-Jakob disease (CJD) with mutation of E200K in PRNP. Methods The general epidemiological and clinical data were collected; CSF 14-3-3 protein was analyzedby Western blot; The PRNP was amplified by PCR and analyzed. Results A missense mutation in codon 200 (E200K) of the PRNP was identified in this patient; CSF 14-3-3 protein was positive; sleep disturbance was the initial sign and the other symptoms gradually appeared, including memory loss, dizziness and ataxia. Conclusion The CJD patient who was first reported in China has a missense mutation in codon 200 (E200K) of the PRNP, and the codon 129 is a methionine homozygous genotype.
Citation: | The First Chinese Case of Creutzfeldt-Jakob Disease with Mutation of E200K in PRNP[J]. Biomedical and Environmental Sciences, 2010, 23(2): 158-160. |