Volume 17 Issue 2
Jun.  2004
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MING-YAN XU, Kun-Xue Hong, XIAO-LING DENG, JUN LI, HONG PENG, Yu-Hua Ruan, GUAN-MING QIN, Hui Xing, XIAO-HU XU, Yi-Ming Shao. Association of HLA-B Alleles With Human Immunodeficiency Virus Type 1 Infection in the Yi Ethnic Group in Sichuan Province[J]. Biomedical and Environmental Sciences, 2004, 17(2): 203-208.
Citation: MING-YAN XU, Kun-Xue Hong, XIAO-LING DENG, JUN LI, HONG PENG, Yu-Hua Ruan, GUAN-MING QIN, Hui Xing, XIAO-HU XU, Yi-Ming Shao. Association of HLA-B Alleles With Human Immunodeficiency Virus Type 1 Infection in the Yi Ethnic Group in Sichuan Province[J]. Biomedical and Environmental Sciences, 2004, 17(2): 203-208.

Association of HLA-B Alleles With Human Immunodeficiency Virus Type 1 Infection in the Yi Ethnic Group in Sichuan Province

Funds:  国家重点基础研究发展计划(973计划)(G1999054107)%the National Key Technologies R & D Program of China during the 15th Five-years Plan Period(2001BA705B02)
  • Objective To determine the distribution of HLA-B alleles in the Chinese Yi ethnic group and its association with HIV infection. Methods One hundred and six unrelated healthy HIV negative and 73 HIV positive Chinese Yi ethnic individuals were typed by PCR-SSP. Results The frequency of alleles B*07, B*35, and B*46 were increased in HIV-1-positive subjects, whereas the alleles B*55, B*44 and B*78 were absent in the HIV-infected persons studied. The B*46 allele was present in a significantly higher gene frequency among HIV-1-positive individuals (P=0.02, OR=3.32, 95% CI=1.13-9.78) compared with control subjects. Conclusion HLA-B*46 may be associated with its susceptibility to HIV-1 infections.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Association of HLA-B Alleles With Human Immunodeficiency Virus Type 1 Infection in the Yi Ethnic Group in Sichuan Province

Funds:  国家重点基础研究发展计划(973计划)(G1999054107)%the National Key Technologies R & D Program of China during the 15th Five-years Plan Period(2001BA705B02)

Abstract: Objective To determine the distribution of HLA-B alleles in the Chinese Yi ethnic group and its association with HIV infection. Methods One hundred and six unrelated healthy HIV negative and 73 HIV positive Chinese Yi ethnic individuals were typed by PCR-SSP. Results The frequency of alleles B*07, B*35, and B*46 were increased in HIV-1-positive subjects, whereas the alleles B*55, B*44 and B*78 were absent in the HIV-infected persons studied. The B*46 allele was present in a significantly higher gene frequency among HIV-1-positive individuals (P=0.02, OR=3.32, 95% CI=1.13-9.78) compared with control subjects. Conclusion HLA-B*46 may be associated with its susceptibility to HIV-1 infections.

MING-YAN XU, Kun-Xue Hong, XIAO-LING DENG, JUN LI, HONG PENG, Yu-Hua Ruan, GUAN-MING QIN, Hui Xing, XIAO-HU XU, Yi-Ming Shao. Association of HLA-B Alleles With Human Immunodeficiency Virus Type 1 Infection in the Yi Ethnic Group in Sichuan Province[J]. Biomedical and Environmental Sciences, 2004, 17(2): 203-208.
Citation: MING-YAN XU, Kun-Xue Hong, XIAO-LING DENG, JUN LI, HONG PENG, Yu-Hua Ruan, GUAN-MING QIN, Hui Xing, XIAO-HU XU, Yi-Ming Shao. Association of HLA-B Alleles With Human Immunodeficiency Virus Type 1 Infection in the Yi Ethnic Group in Sichuan Province[J]. Biomedical and Environmental Sciences, 2004, 17(2): 203-208.

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