Zinc In CCl4 Toxicity

O.ADEMUYIWA; O.ONITILO; O.DOSUMU; O.AYANNUGA; A.BAKARE; W.AKINLATUN; E.O.OGUNYEMI

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Volume 15 Issue 3

Sep. 2002

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Article Navigation > Biomedical and Environmental Sciences > 2002 > 15(3): 187-195

O.ADEMUYIWA, O.ONITILO, O.DOSUMU, O.AYANNUGA, A.BAKARE, W.AKINLATUN, E.O.OGUNYEMI. Zinc In CCl4 Toxicity[J]. Biomedical and Environmental Sciences, 2002, 15(3): 187-195.

Citation:

O.ADEMUYIWA, O.ONITILO, O.DOSUMU, O.AYANNUGA, A.BAKARE, W.AKINLATUN, E.O.OGUNYEMI. Zinc In CCl4 Toxicity[J]. Biomedical and Environmental Sciences, 2002, 15(3): 187-195.

Zinc In CCl4 Toxicity

Department of Biochemistry and University of Agriculture, Abeokuta, Nigeria;Department of Biochemistry, University of Agriculture, Abeokuta, Nigeria
Department of Biochemistry and University of Agriculture, Abeokuta, Nigeria
Department of Chemical Pathology, Ogun State University, Ago-Iwoye, Nigeria and University of Agriculture, Abeokuta, Nigeria

Abstract

Objective To investigate the protective effect of zinc in CCl4-induced hepatotoxicity. Methods Rats were treated with zinc acetate for four days. The zinc doses were 5 mg Zn/kg and 10 mg Zn/kg body weight respectively. Two groups of the zinc acetate-treated rats were later challenged with a single dose of CCl4 (1.5 mL/kg body weight). Results Compared to control animals, the plasma of rats treated with CCl4 showed hyperbilirubinaemia, hypoglycaemia, hypercreatinaemia and hypoproteinaemia. When the animals were however supplemented with zinc in form of zinc acetate before being dosed with CCl4, the 5 mg Zn/kg body weight of zinc acetate reversed the hypoproteinaemia induced by CCl4, whereas the 10mg Zn/kg body weight of zinc acetate reversed the hypoglycaemia, hyperbilimbinaemia and hypercreatinaemia induced by CCl4. Conclusion The 10mug Zn/kg body weight of zinc acetate is more consistent in protecting against CCl4 hepatotoxicity. The possible mechanisms of protection are highlighted.
- CCl4,
- Zinc,
- Plasma,
- Hypoglycaemia,
- Hyperbilirubinaemia,
- Hypercreatinaemia
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沈阳化工大学材料科学与工程学院沈阳 110142

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Zinc In CCl4 Toxicity

Department of Biochemistry and University of Agriculture, Abeokuta, Nigeria;Department of Biochemistry, University of Agriculture, Abeokuta, Nigeria

Department of Biochemistry and University of Agriculture, Abeokuta, Nigeria

Department of Chemical Pathology, Ogun State University, Ago-Iwoye, Nigeria and University of Agriculture, Abeokuta, Nigeria

Key words:

Abstract: Objective To investigate the protective effect of zinc in CCl4-induced hepatotoxicity. Methods Rats were treated with zinc acetate for four days. The zinc doses were 5 mg Zn/kg and 10 mg Zn/kg body weight respectively. Two groups of the zinc acetate-treated rats were later challenged with a single dose of CCl4 (1.5 mL/kg body weight). Results Compared to control animals, the plasma of rats treated with CCl4 showed hyperbilirubinaemia, hypoglycaemia, hypercreatinaemia and hypoproteinaemia. When the animals were however supplemented with zinc in form of zinc acetate before being dosed with CCl4, the 5 mg Zn/kg body weight of zinc acetate reversed the hypoproteinaemia induced by CCl4, whereas the 10mg Zn/kg body weight of zinc acetate reversed the hypoglycaemia, hyperbilimbinaemia and hypercreatinaemia induced by CCl4. Conclusion The 10mug Zn/kg body weight of zinc acetate is more consistent in protecting against CCl4 hepatotoxicity. The possible mechanisms of protection are highlighted.

O.ADEMUYIWA, O.ONITILO, O.DOSUMU, O.AYANNUGA, A.BAKARE, W.AKINLATUN, E.O.OGUNYEMI. Zinc In CCl4 Toxicity[J]. Biomedical and Environmental Sciences, 2002, 15(3): 187-195.

Citation:

O.ADEMUYIWA, O.ONITILO, O.DOSUMU, O.AYANNUGA, A.BAKARE, W.AKINLATUN, E.O.OGUNYEMI. Zinc In CCl4 Toxicity[J]. Biomedical and Environmental Sciences, 2002, 15(3): 187-195.