Volume 21 Issue 6
Dec.  2008
Turn off MathJax
Article Contents

SHU-HUA WANG, HUI XING, XIANG HE, FENG-XIA ZHU, ZHE-FENG MENG, YU-HUA RUAN, YI-MING SHAO. Nef Mutations in Long-term Non-progressors from Former Plasma Donors Infected with HIV-1 Subtype B in China[J]. Biomedical and Environmental Sciences, 2008, 21(6): 485-491.
Citation: SHU-HUA WANG, HUI XING, XIANG HE, FENG-XIA ZHU, ZHE-FENG MENG, YU-HUA RUAN, YI-MING SHAO. Nef Mutations in Long-term Non-progressors from Former Plasma Donors Infected with HIV-1 Subtype B in China[J]. Biomedical and Environmental Sciences, 2008, 21(6): 485-491.

Nef Mutations in Long-term Non-progressors from Former Plasma Donors Infected with HIV-1 Subtype B in China

Funds:  NIH CIPRA grant(U19A151915-03)%国家高技术研究发展计划(863计划)(2006AA02Z418)%国家重点基础研究发展规划(973计划)(2005 CB522903)
  • To study the specific amino acid variation in Nef that may be related to disease progression after infection with HIV-1 subtype B,a predominant strain circulating in China,and to determine whether changes in Nef secondary structure may influence different stages of AIDS development based on the concept that the Nef gene of HIV infection dramatically alter the severity of viral infection and virus replication and disease progression,and that long-term non-progressors (LTNP) of HIV infection are commonly associated with either a deletion of the Nef gene or the defective Nef alleles.Methods The study subjects were divided into LTNP1(n=14),LTNP2 (n=16) and slow progressor (SP,n=19) groups for mutational analysis of the Nef sequence.The data were obtained by using Bioedit,MEGA,Anthewin and SAS software.Results Residues in Nef TA48/49 and K151 occurred more frequently in the LTNP group while AA48/49 was more frequendy observed in the SP group.Of the differences observed in the secondary structure comparison using Nef consensus sequences of these three groups,one was roughly corresponding to the Nef48/49 mutation site.Conclusion TA48/49,K151,and A48/49 in the Nef gene might be associated with the different stages of HIV infection,and there may be a link between the Nef secondary structure and the progression of HIV-1 infection.
  • 加载中
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(1267) PDF downloads(23) Cited by()

Proportional views
Related

Nef Mutations in Long-term Non-progressors from Former Plasma Donors Infected with HIV-1 Subtype B in China

Funds:  NIH CIPRA grant(U19A151915-03)%国家高技术研究发展计划(863计划)(2006AA02Z418)%国家重点基础研究发展规划(973计划)(2005 CB522903)

Abstract: To study the specific amino acid variation in Nef that may be related to disease progression after infection with HIV-1 subtype B,a predominant strain circulating in China,and to determine whether changes in Nef secondary structure may influence different stages of AIDS development based on the concept that the Nef gene of HIV infection dramatically alter the severity of viral infection and virus replication and disease progression,and that long-term non-progressors (LTNP) of HIV infection are commonly associated with either a deletion of the Nef gene or the defective Nef alleles.Methods The study subjects were divided into LTNP1(n=14),LTNP2 (n=16) and slow progressor (SP,n=19) groups for mutational analysis of the Nef sequence.The data were obtained by using Bioedit,MEGA,Anthewin and SAS software.Results Residues in Nef TA48/49 and K151 occurred more frequently in the LTNP group while AA48/49 was more frequendy observed in the SP group.Of the differences observed in the secondary structure comparison using Nef consensus sequences of these three groups,one was roughly corresponding to the Nef48/49 mutation site.Conclusion TA48/49,K151,and A48/49 in the Nef gene might be associated with the different stages of HIV infection,and there may be a link between the Nef secondary structure and the progression of HIV-1 infection.

SHU-HUA WANG, HUI XING, XIANG HE, FENG-XIA ZHU, ZHE-FENG MENG, YU-HUA RUAN, YI-MING SHAO. Nef Mutations in Long-term Non-progressors from Former Plasma Donors Infected with HIV-1 Subtype B in China[J]. Biomedical and Environmental Sciences, 2008, 21(6): 485-491.
Citation: SHU-HUA WANG, HUI XING, XIANG HE, FENG-XIA ZHU, ZHE-FENG MENG, YU-HUA RUAN, YI-MING SHAO. Nef Mutations in Long-term Non-progressors from Former Plasma Donors Infected with HIV-1 Subtype B in China[J]. Biomedical and Environmental Sciences, 2008, 21(6): 485-491.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return