Volume 19 Issue 5
Oct.  2006
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Article Navigation >  Biomedical and Environmental Sciences  > 2006  >  19(5): 367-370

FANG HUANG, LIN-HUA TANG, LIN-QIAN YU, YI-CHANG NI, QIN-MEI WANG, FA-JUN NAN. In vitro Potentiation of Antimalarial Activities by Daphnetin Derivatives Against Plasmodium falciparum[J]. Biomedical and Environmental Sciences, 2006, 19(5): 367-370.
Citation: FANG HUANG, LIN-HUA TANG, LIN-QIAN YU, YI-CHANG NI, QIN-MEI WANG, FA-JUN NAN. In vitro Potentiation of Antimalarial Activities by Daphnetin Derivatives Against Plasmodium falciparum[J]. Biomedical and Environmental Sciences, 2006, 19(5): 367-370.
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In vitro Potentiation of Antimalarial Activities by Daphnetin Derivatives Against Plasmodium falciparum

  • National Institute of Parasite Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China

  • Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 201203, China

  • Objective To screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro. Method Plasmodium faciparum (FCC1) was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method. Results DA79 and DA78 showed potent antimalarial activity against Plasmodium falciparum cultured in vitro. Conclusion Though the relationship between the structures of daphnetin derivatives and their antimalarial activities has not been clarified yet, this study may provide a new direction for discovery of more potential antimalarial compounds.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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In vitro Potentiation of Antimalarial Activities by Daphnetin Derivatives Against Plasmodium falciparum

  • National Institute of Parasite Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China
  • Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 201203, China

Abstract: Objective To screen the antimalarial compounds of daphnetin derivatives against Plasmodium falciparum in vitro. Method Plasmodium faciparum (FCC1) was cultured in vitro by a modified method of Trager and Jensen. Antimalarial compounds were screened by microscopy-based assay and microfluorimetric method. Results DA79 and DA78 showed potent antimalarial activity against Plasmodium falciparum cultured in vitro. Conclusion Though the relationship between the structures of daphnetin derivatives and their antimalarial activities has not been clarified yet, this study may provide a new direction for discovery of more potential antimalarial compounds.

FANG HUANG, LIN-HUA TANG, LIN-QIAN YU, YI-CHANG NI, QIN-MEI WANG, FA-JUN NAN. In vitro Potentiation of Antimalarial Activities by Daphnetin Derivatives Against Plasmodium falciparum[J]. Biomedical and Environmental Sciences, 2006, 19(5): 367-370.
Citation: FANG HUANG, LIN-HUA TANG, LIN-QIAN YU, YI-CHANG NI, QIN-MEI WANG, FA-JUN NAN. In vitro Potentiation of Antimalarial Activities by Daphnetin Derivatives Against Plasmodium falciparum[J]. Biomedical and Environmental Sciences, 2006, 19(5): 367-370.
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