Volume 12 Issue 4
Dec.  1999
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Article Navigation >  Biomedical and Environmental Sciences  > 1999  >  12(4): 285-291

GOVINDER J.S.FLORA, USHA ARORA, ARD PRAHLAD K.SETH. Influence of Combined Therapeutic Potential of Meso 2, 3-dimercaptosuccinic Acid and Calcium Disodium Edetate on Lead-induced Testicular Alterations in Rats[J]. Biomedical and Environmental Sciences, 1999, 12(4): 285-291.
Citation: GOVINDER J.S.FLORA, USHA ARORA, ARD PRAHLAD K.SETH. Influence of Combined Therapeutic Potential of Meso 2, 3-dimercaptosuccinic Acid and Calcium Disodium Edetate on Lead-induced Testicular Alterations in Rats[J]. Biomedical and Environmental Sciences, 1999, 12(4): 285-291.
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Influence of Combined Therapeutic Potential of Meso 2, 3-dimercaptosuccinic Acid and Calcium Disodium Edetate on Lead-induced Testicular Alterations in Rats

  • Industrial Toxicology Research Centre, Post Box 80, Lucknow, India

  • Defence Research and Development Establishment, Gwalior, India

  • The therapeutic efficacy of a combination of meso 2,3-dimercaptosuccinic acid (DMSA) and calcium disodium EDTA in protecting testicular disorders in chronic lead intoxication was investigated. The results indicate that two five-days courses of the combined therapy produced a more effective recovery in the lead induced biochemical and histopathological disorders compared to conventional single 5 days therapy. No adverse effect of the chelators, when administered individually or in combination, was noticed in the testes of control (without lead exposure) animals.
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Influence of Combined Therapeutic Potential of Meso 2, 3-dimercaptosuccinic Acid and Calcium Disodium Edetate on Lead-induced Testicular Alterations in Rats

  • Industrial Toxicology Research Centre, Post Box 80, Lucknow, India
  • Defence Research and Development Establishment, Gwalior, India

Abstract: The therapeutic efficacy of a combination of meso 2,3-dimercaptosuccinic acid (DMSA) and calcium disodium EDTA in protecting testicular disorders in chronic lead intoxication was investigated. The results indicate that two five-days courses of the combined therapy produced a more effective recovery in the lead induced biochemical and histopathological disorders compared to conventional single 5 days therapy. No adverse effect of the chelators, when administered individually or in combination, was noticed in the testes of control (without lead exposure) animals.

GOVINDER J.S.FLORA, USHA ARORA, ARD PRAHLAD K.SETH. Influence of Combined Therapeutic Potential of Meso 2, 3-dimercaptosuccinic Acid and Calcium Disodium Edetate on Lead-induced Testicular Alterations in Rats[J]. Biomedical and Environmental Sciences, 1999, 12(4): 285-291.
Citation: GOVINDER J.S.FLORA, USHA ARORA, ARD PRAHLAD K.SETH. Influence of Combined Therapeutic Potential of Meso 2, 3-dimercaptosuccinic Acid and Calcium Disodium Edetate on Lead-induced Testicular Alterations in Rats[J]. Biomedical and Environmental Sciences, 1999, 12(4): 285-291.
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