[1] GBD 2019 Dementia Forecasting Collaborators. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health, 2022; 7, e105−25. doi:  10.1016/S2468-2667(21)00249-8
[2] Vetrano DL, Rizzuto D, Calderón-Larrañaga A, et al. Trajectories of functional decline in older adults with neuropsychiatric and cardiovascular multimorbidity: a Swedish cohort study. PLoS Med, 2018; 15, e1002503. doi:  10.1371/journal.pmed.1002503
[3] Jia JP, Wei CB, Chen SQ, et al. The cost of Alzheimer’s disease in China and re-estimation of costs worldwide. Alzheimers Dement, 2018; 14, 483-91. 4. 2020 Alzheimer’s disease facts and figures. Alzheimers Dement, 2020; 16, 391-460.
[4] 2020 Alzheimer’s disease facts and figures. Alzheimers Dement, 2020; 16, 391-460.
[5] Qi SG, Yin P, Zhang H, et al. Prevalence of dementia in China in 2015: a nationwide community-based study. Front Public Health, 2021; 9, 733314. doi:  10.3389/fpubh.2021.733314
[6] Shimada H, Makizako H, Lee S, et al. Lifestyle activities and the risk of dementia in older Japanese adults. Geriatr Gerontol Int, 2018; 18, 1491−6. doi:  10.1111/ggi.13504
[7] Jang JW, Park JH, Kim S, et al. Prevalence and incidence of dementia in South Korea: a nationwide analysis of the national health insurance service senior cohort. J Clin Neurol, 2021; 17, 249−56. doi:  10.3988/jcn.2021.17.2.249
[8] Wolters FJ, Chibnik LB, Waziry R, et al. Twenty-seven-year time trends in dementia incidence in Europe and the United States: the Alzheimer Cohorts Consortium. Neurology, 2020; 95, e519−31.
[9] Satizabal CL, Beiser AS, Chouraki V, et al. Incidence of dementia over three decades in the Framingham heart study. N Engl J Med, 2016; 374, 523−32. doi:  10.1056/NEJMoa1504327
[10] GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 2017; 390, 1211−59. doi:  10.1016/S0140-6736(17)32154-2
[11] Thiankhaw K, Chattipakorn N, Chattipakorn SC. PM2.5 exposure in association with AD-related neuropathology and cognitive outcomes. Environ Pollut, 2022; 292, 118320. doi:  10.1016/j.envpol.2021.118320
[12] Calderón-Garcidueñas L, Avila-Ramírez J, Calderón-Garcidueñas A, et al. Cerebrospinal fluid biomarkers in highly exposed PM2.5 urbanites: the risk of Alzheimer’s and Parkinson’s diseases in Young Mexico City residents. J Alzheimers Dis, 2016; 54, 597−613. doi:  10.3233/JAD-160472
[13] Shou YK, Huang YL, Zhu XZ, et al. A review of the possible associations between ambient PM2.5 exposures and the development of Alzheimer’s disease. Ecotoxicol Environ Saf, 2019; 174, 344−52. doi:  10.1016/j.ecoenv.2019.02.086
[14] Kang YJ, Tan HY, Lee CY, et al. An air particulate pollutant induces neuroinflammation and neurodegeneration in human brain models. Adv Sci (Weinh), 2021; 8, e2101251. doi:  10.1002/advs.202101251
[15] Lee SH, Chen YH, Chien CC, et al. Three month inhalation exposure to low-level PM2.5 induced brain toxicity in an Alzheimer’s disease mouse model. PLoS One, 2021; 16, e0254587. doi:  10.1371/journal.pone.0254587
[16] Carey IM, Anderson HR, Atkinson RW, et al. Are noise and air pollution related to the incidence of dementia? A cohort study in London, England. BMJ Open, 2018; 8, e022404. doi:  10.1136/bmjopen-2018-022404
[17] Dimakakou E, Johnston HJ, Streftaris G, et al. Is environmental and occupational particulate air pollution exposure related to type-2 diabetes and dementia? A cross-sectional analysis of the UK Biobank. Int J Environ Res Public Health, 2020; 17, 9581. doi:  10.3390/ijerph17249581
[18] Fonken LK, Xu X, Weil ZM, et al. Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology. Mol Psychiatry, 2011; 16, 987−95. doi:  10.1038/mp.2011.76
[19] Johannson KA, Balmes JR, Collard HR. Air pollution exposure: a novel environmental risk factor for interstitial lung disease? Chest, 2015; 147, 1161-7.
[20] Illum L. Transport of drugs from the nasal cavity to the central nervous system. Eur J Pharm Sci, 2000; 11, 1−18. doi:  10.1016/S0928-0987(00)00087-7
[21] Stone V, Miller MR, Clift MJD, et al. Nanomaterials versus ambient ultrafine particles: an opportunity to exchange toxicology knowledge. Environ Health Perspect, 2017; 125, 106002. doi:  10.1289/EHP424
[22] Balasubramanian SK, Poh KW, Ong CN, et al. The effect of primary particle size on biodistribution of inhaled gold nano-agglomerates. Biomaterials, 2013; 34, 5439−52. doi:  10.1016/j.biomaterials.2013.03.080
[23] Elder A, Gelein R, Silva V, et al. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect, 2006; 114, 1172−8. doi:  10.1289/ehp.9030
[24] Anstey KJ, von Sanden C, Salim A, et al. Smoking as a risk factor for dementia and cognitive decline: a meta-analysis of prospective studies. Am J Epidemiol, 2007; 166, 367−78. doi:  10.1093/aje/kwm116
[25] Hahad O, Daiber A, Michal M, et al. Smoking and neuropsychiatric disease-associations and underlying mechanisms. Int J Mol Sci, 2021; 22, 7272. doi:  10.3390/ijms22147272
[26] Jia RR, Wang Q, Huang HY, et al. Cardiovascular disease risk models and dementia or cognitive decline: a systematic review. Front Aging Neurosci, 2023; 15, 1257367. doi:  10.3389/fnagi.2023.1257367
[27] Norton S, Matthews FE, Barnes DE, et al. Potential for primary prevention of Alzheimer’s disease: an analysis of population-based data. Lancet Neurol, 2014; 13, 788−94. doi:  10.1016/S1474-4422(14)70136-X
[28] Wang ZH, Qi SG, Zhang H, et al. Design and implementation of a project-prevention and intervention on neurodegenerative disease in the elderly. Chin J Public Health, 2021; 37, 1585−9. (In Chinese)
[29] Van Donkelaar A, Martin RV, Brauer M, et al. Global estimates of fine particulate matter using a combined geophysical-statistical method with information from satellites, models, and monitors. Environ Sci Technol, 2016; 50, 3762−72. doi:  10.1021/acs.est.5b05833
[30] Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res, 1975; 12, 189−98. doi:  10.1016/0022-3956(75)90026-6
[31] Li T, Wang HL, Yang YH, et al. The reliability and validity of Chinese version of AD8. Chin J Intern Med, 2012; 51, 777−80. (In Chinese)
[32] Zhou B, Coorperative Meta-analysis Group of China Obesity Task Force. Predictive values of body mass index and waist circumference to risk factors of related diseases in Chinese adult population. Chin J Epidemiol, 2002; 23, 5−10. (In Chinese)
[33] Zhang W, Niu XY, Gao SW, et al. Evaluation of a screening questionnaire for Parkinson’s disease in a Chinese population. J Clin Neurosci, 2014; 21, 278−81. doi:  10.1016/j.jocn.2013.03.027
[34] Li ZZ, Tang Z, Wang R. Status of elderly disability in 7 cities of China. Chin J Epidemiol, 2016; 37, 1561−4. (In Chinese)
[35] Paul KC, Haan M, Mayeda ER, et al. Ambient air pollution, noise, and late-life cognitive decline and dementia risk. Annu Rev Public Health, 2019; 40, 203−20. doi:  10.1146/annurev-publhealth-040218-044058
[36] Delgado-Saborit JM, Guercio V, Gowers AM, et al. A critical review of the epidemiological evidence of effects of air pollution on dementia, cognitive function and cognitive decline in adult population. Sci Total Environ, 2021; 757, 143734. doi:  10.1016/j.scitotenv.2020.143734
[37] Mortamais M, Gutierrez LA, De Hoogh K, et al. Long-term exposure to ambient air pollution and risk of dementia: results of the prospective Three-City Study. Environ Int, 2021; 148, 106376. doi:  10.1016/j.envint.2020.106376
[38] Wang JN, Li TT, Lv YB, et al. Fine particulate matter and poor cognitive function among Chinese older adults: evidence from a community-based, 12-year prospective cohort study. Environ Health Perspect, 2020; 128, 067013. doi:  10.1289/EHP5304
[39] Yao YF, Wang K, Xiang H. Association between cognitive function and ambient particulate matters in middle-aged and elderly Chinese adults: evidence from the China Health and Retirement Longitudinal Study (CHARLS). Sci Total Environ, 2022; 828, 154297. doi:  10.1016/j.scitotenv.2022.154297
[40] Hu XM, Nie ZQ, Ou YQ, et al. Air quality improvement and cognitive function benefit: insight from clean air action in China. Environ Res, 2022; 214, 114200. doi:  10.1016/j.envres.2022.114200
[41] Ailshire JA, Clarke P. Fine particulate matter air pollution and cognitive function among U. S. older adults. J Gerontol B Psychol Sci Soc Sci, 2015; 70, 322−8. doi:  10.1093/geronb/gbu064
[42] Abner EL, Nelson PT, Jicha GA, et al. Tobacco smoking and dementia in a Kentucky cohort: a competing risk analysis. J Alzheimers Dis, 2019; 68, 625−33. doi:  10.3233/JAD-181119
[43] Otuyama LJ, Oliveira D, Locatelli D, et al. Tobacco smoking and risk for dementia: evidence from the 10/66 population-based longitudinal study. Aging Ment Health, 2020; 24, 1796−806. doi:  10.1080/13607863.2019.1647140
[44] Nourse JB, Harshefi G, Marom A, et al. Conserved nicotine-activated neuroprotective pathways involve mitochondrial stress. Iscience, 2021; 24, 102140. doi:  10.1016/j.isci.2021.102140
[45] Zhong GC, Wang Y, Zhang Y, et al. Smoking is associated with an increased risk of dementia: a meta-analysis of prospective cohort studies with investigation of potential effect modifiers. PLoS One, 2015; 10, e0118333. doi:  10.1371/journal.pone.0118333
[46] Chan KH, Xiao D, Zhou MG, et al. Tobacco control in China. Lancet Public Health, 2023; 8, e1006−15. doi:  10.1016/S2468-2667(23)00242-6
[47] Chen GC, Hukportie DN, Wan ZX, et al. The association between exposure to air pollution and dementia incidence: the modifying effect of smoking. J Gerontol A Biol Sci Med Sci, 2023; 78, 2309−17. doi:  10.1093/gerona/glac228
[48] Grande G, Qiu CX, Fratiglioni L. Prevention of dementia in an ageing world: evidence and biological rationale. Ageing Res Rev, 2020; 64, 101045. doi:  10.1016/j.arr.2020.101045
[49] Fujita Y, Maki K. Associations of smoking behavior with lifestyle and mental health among Japanese dental students. BMC Med Educ, 2018; 18, 264. doi:  10.1186/s12909-018-1365-1
[50] Künzli N, Jerrett M, Mack WJ, et al. Ambient air pollution and atherosclerosis in Los Angeles. Environ Health Perspect, 2005; 113, 201−6. doi:  10.1289/ehp.7523
[51] Akiyama H, Arai T, Kondo H, et al. Cell mediators of inflammation in the Alzheimer disease brain. Alzheimer Dis Assoc Disord, 2000; 14, S47−53. doi:  10.1097/00002093-200000001-00008
[52] Amor S, Puentes F, Baker D, et al. Inflammation in neurodegenerative diseases. Immunology, 2010; 129, 154−69. doi:  10.1111/j.1365-2567.2009.03225.x
[53] Liang FC, Liu FC, Huang KY, et al. Long-term exposure to fine particulate matter and cardiovascular disease in China. J Am Coll Cardiol, 2020; 75, 707−17.