| [1] | GBD 2021 Adolescent BMI Collaborators. Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990-2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021. Lancet, 2025; 405, 785−812. doi: 10.1016/S0140-6736(25)00397-6 |
| [2] | Rubino F, Cummings DE, Eckel RH, et al. Definition and diagnostic criteria of clinical obesity. Lancet Diabetes Endocrinol, 2025; 13, 221−62. doi: 10.1016/S2213-8587(24)00316-4 |
| [3] | Wildman RP, Muntner P, Reynolds K, et al. The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med, 2008; 168, 1617−24. |
| [4] | Ross R, Neeland IJ, Yamashita S, et al. Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity. Nat Rev Endocrinol, 2020; 16, 177−89. doi: 10.1038/s41574-019-0310-7 |
| [5] | Zhang ST, Li WY, Jia XF, et al. Association of obesity profiles with type 2 diabetes in Chinese adults: findings from the China health and nutrition survey. Front Nutr, 2022; 9, 922824. doi: 10.3389/fnut.2022.922824 |
| [6] | Klein S, Gastaldelli A, Yki-Järvinen H, et al. Why does obesity cause diabetes? Cell Metab, 2022; 34, 11-20. |
| [7] | Ndumele CE, Neeland IJ, Tuttle KR, et al. A synopsis of the evidence for the science and clinical management of Cardiovascular-Kidney-Metabolic (CKM) syndrome: a scientific statement from the American Heart Association. Circulation, 2023; 148, 1636−64. doi: 10.1161/CIR.0000000000001186 |
| [8] | Powell-Wiley TM, Poirier P, Burke LE, et al. Obesity and cardiovascular disease: a scientific statement from the American Heart Association. Circulation, 2021; 143, e984−1010. |
| [9] | Yang M, Liu J, Shen Q, et al. Body roundness index trajectories and the incidence of cardiovascular disease: evidence from the China health and retirement longitudinal study. J Am Heart Assoc, 2024; 13, e034768. doi: 10.1161/JAHA.124.034768 |
| [10] | Jayedi A, Soltani S, Zargar MS, et al. Central fatness and risk of all cause mortality: systematic review and dose-response meta-analysis of 72 prospective cohort studies. BMJ, 2020; 370, m3324. |
| [11] | Xiao TL, Yuan SQ, Gao JY, et al. Predictive ability of Hypertriglyceridemic waist, Hypertriglyceridemic waist-to-height ratio, and waist-to-hip ratio for cardiometabolic risk factors clustering screening among Chinese children and adolescents. Biomed Environ Sci, 2024; 37, 233−41. |
| [12] | Wong MCS, Huang JJ, Wang JX, et al. Global, regional and time-trend prevalence of central obesity: a systematic review and meta-analysis of 13.2 million subjects. Eur J Epidemiol, 2020; 35, 673−83. |
| [13] | Nan J, Chen ML, Yuan HT, et al. Waist circumference status and distribution in Chinese adults: China nutrition and health surveillance (2015-2017). Biomed Environ Sci, 2025; 38, 757−62. |
| [14] | Zhang ST, Zhang JG, Jia XF, et al. Secular trends in central obesity prevalence and demographic and socioeconomic factors of adults aged 18-35 years in 15 provinces (autonomous regions and municipalities) of China from 1993 to 2018. J Environ Occup Med, 2022; 39, 323−30. (In Chinese) |
| [15] | Xiong Y, Tang YJ, Zhou J, et al. Childhood adiposity and risk of major clinical heart diseases in adulthood: a mendelian randomization study. J Am Heart Assoc, 2024; 13, e035365. doi: 10.1161/JAHA.124.035365 |
| [16] | Dong YH, Ma J, Song Y, et al. Secular trends in blood pressure and overweight and obesity in Chinese boys and girls aged 7 to 17 years from 1995 to 2014. Hypertension, 2018; 72, 298−305. doi: 10.1161/HYPERTENSIONAHA.118.11291 |
| [17] | Feng L, Nian SY, Tong ZW, et al. Age-related trends in lipid levels: a large-scale cross-sectional study of the general Chinese population. BMJ Open, 2020; 10, e034226. doi: 10.1136/bmjopen-2019-034226 |
| [18] | Peng X, Zhang BS, Chen ZX, et al. Association between urinary phthalate and bisphenol exposures and obesity based on body mass index and waist circumference. Biomed Environ Sci, 2025; 38, 1155−60. |
| [19] | Simmonds M, Llewellyn A, Owen CG, et al. Predicting adult obesity from childhood obesity: a systematic review and meta-analysis. Obes Rev, 2016; 17, 95−107. doi: 10.1111/obr.12334 |
| [20] | Gao CN, Meng X, Liu W, et al. Identification of sensitive periods of weight status transition over the lifespan in Chinese population. BMC Med, 2024; 22, 507. doi: 10.1186/s12916-024-03721-4 |
| [21] | Wagner C, Carmeli C, Jackisch J, et al. Life course epidemiology and public health. Lancet Public Health, 2024; 9, e261−9. doi: 10.1016/S2468-2667(24)00018-5 |
| [22] | Zhang B, Zhai FY, Du SF, et al. The China health and nutrition survey, 1989-2011. Obes Rev, 2014; 15 Suppl 1, 2-7. |
| [23] | Zong XN, Li H, Zhang YQ, et al. Percentile reference value of waist circumference for Chinese children aged 3-7 years. Chin J Epidemiol, 2020; 41, 1286−90. (In Chinese) |
| [24] | Ma GS, Ji CY, Ma J, et al. Waist circumference reference values for screening cardiovascular risk factors in Chinese children and adolescents aged 7-18 years. Chin J Epidemiol, 2010; 31, 609−15. (In Chinese) |
| [25] | National Health and Family Planning Commission of the People's Republic of China. (2013). WS/T 428-2013 Criteria of weight for adults. (In Chinese)https://www.nhc.gov.cn/wjw/yingyang/201308/a233d450fdbc47c5ad4f08b7e394d1e8.shtml |
| [26] | World Health Organization. Global accelerated action for the health of adolescents (AA-HA!): guidance to support country implementation. 2nd ed. World Health Organization. 2023. |
| [27] | Casals M, Girabent-Farrés M, Carrasco JL. Methodological quality and reporting of generalized linear mixed models in clinical medicine (2000-2012): a systematic review. PLoS One, 2014; 9, e112653. doi: 10.1371/journal.pone.0112653 |
| [28] | Halfon N, Forrest CB. The emerging theoretical framework of life course health development. In: Halfon N, Forrest CB, Lerner RM, et al. Handbook of Life Course Health Development. Springer. 2018, 19-43. |
| [29] | Volger S, Rigassio Radler D, Rothpletz-Puglia P. Early childhood obesity prevention efforts through a life course health development perspective: a scoping review. PLoS One, 2018; 13, e0209787. doi: 10.1371/journal.pone.0209787 |
| [30] | Nielsen J, Hulman A, Narayan KMV, et al. Body mass index trajectories from childhood to adulthood and age at onset of overweight and obesity: the influence of parents' weight status. Am J Epidemiol, 2022; 191, 1877−85. doi: 10.1093/aje/kwac124 |
| [31] | Ziauddeen N, Roderick PJ, Macklon NS, et al. Predicting childhood overweight and obesity using maternal and early life risk factors: a systematic review. Obes Rev, 2018; 19, 302−12. doi: 10.1111/obr.12640 |
| [32] | Matsumoto N, Kubo T, Nakamura K, et al. Trajectory of body mass index and height changes from childhood to adolescence: a nationwide birth cohort in Japan. Sci Rep, 2021; 11, 23004. doi: 10.1038/s41598-021-02464-z |
| [33] | Suh J, Jeon YW, Lee JH, et al. Annual incidence and prevalence of obesity in childhood and young adulthood based on a 30-year longitudinal population-based cohort study in Korea: the Kangwha study. Ann Epidemiol, 2021; 62, 1−6. |
| [34] | Ward ZJ, Long MW, Resch SC, et al. Simulation of growth trajectories of childhood obesity into adulthood. N Engl J Med, 2017; 377, 2145−53. doi: 10.1056/NEJMoa1703860 |
| [35] | Song XL, Zhou B, Baird S, et al. Trends and predictions to 2030 in demographic structures and metabolic health for children and adolescents in China: analysis of national school health surveys from 2000 to 2019. Lancet Child Adolesc Health, 2025; 9, 530−43. doi: 10.1016/S2352-4642(25)00140-3 |
| [36] | World Obesity Federation. World obesity atlas 2025. World Obesity Federation. 2025. |
| [37] | Dong YH, Yuan CZ, Dang JJ, et al. Control of childhood obesity and implications for policy in China. Lancet Public Health, 2024; 9, e1125−35. doi: 10.1016/S2468-2667(24)00263-9 |
| [38] | Pan XF, Wang LM, Pan A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol, 2021; 9, 373−92. doi: 10.1016/S2213-8587(21)00045-0 |
| [39] | Koceva A, Herman R, Janez A, et al. Sex- and gender-related differences in obesity: from pathophysiological mechanisms to clinical implications. Int J Mol Sci, 2024; 25, 7342. doi: 10.3390/ijms25137342 |
| [40] | Karastergiou K, Smith SR, Greenberg AS, et al. Sex differences in human adipose tissues - the biology of pear shape. Biol Sex Differ, 2012; 3, 13. doi: 10.1186/2042-6410-3-13 |
| [41] | Jackson AS, Stanforth PR, Gagnon J, et al. The effect of sex, age and race on estimating percentage body fat from body mass index: the Heritage Family Study. Int J Obes, 2002; 26, 789−96. |
| [42] | Christen T, Trompet S, Noordam R, et al. Sex differences in body fat distribution are related to sex differences in serum leptin and adiponectin. Peptides, 2018; 107, 25−31. doi: 10.1016/j.peptides.2018.07.008 |
| [43] | Mauvais-Jarvis F. Sex differences in energy metabolism: natural selection, mechanisms and consequences. Nat Rev Nephrol, 2024; 20, 56−69. doi: 10.1038/s41581-023-00781-2 |
| [44] | Palmer BF, Clegg DJ. The sexual dimorphism of obesity. Mol Cell Endocrinol, 2015; 402, 113−9. doi: 10.1016/j.mce.2014.11.029 |
| [45] | Gavin KM, Bessesen DH. Sex differences in adipose tissue function. Endocrinol Metab Clin North Am, 2020; 49, 215−28. |
| [46] | He J, Xie YX. The sociocultural mechanism of obesity: the influence of gender role attitudes on obesity and the gender gap. Soc Sci Med, 2022; 293, 114655. doi: 10.1016/j.socscimed.2021.114655 |
| [47] | Ata RN, Ludden AB, Lally MM. The effects of gender and family, friend, and media influences on eating behaviors and body image during adolescence. J Youth Adolesc, 2007; 36, 1024−37. doi: 10.1007/s10964-006-9159-x |
| [48] | Dougherty EN, Goldschmidt AB, Johnson NK, et al. Gender differences in the relation between interpersonal stress and momentary shape and weight concerns in youth with overweight/obesity. Body Image, 2022; 40, 249−55. doi: 10.1016/j.bodyim.2022.01.006 |
| [49] | Marcus C, Danielsson P, Hagman E. Pediatric obesity-long-term consequences and effect of weight loss. J Intern Med, 2022; 292, 870−91. doi: 10.1111/joim.13547 |
| [50] | Yan YK, Hou DQ, Liang YJ, et al. Tracking body mass index from childhood to adulthood for subclinical cardiovascular diseases at adulthood. J Am Coll Cardiol, 2016; 67, 1006−7. doi: 10.1016/j.jacc.2015.12.013 |
| [51] | Yuan CZ, Dong YH, Chen H, et al. Public health interventions against childhood obesity in China. Lancet Public Health, 2024; 9, e1115−24. doi: 10.1016/S2468-2667(24)00245-7 |