| [1] | International Diabetes Federation. IDF diabetes atlas. 10th ed. IDF. 2021. |
| [2] | GBD 2019 Diabetes and Air Pollution Collaborators. Estimates, trends, and drivers of the global burden of type 2 diabetes attributable to PM2.5 air pollution, 1990-2019: an analysis of data from the Global Burden of Disease Study 2019. Lancet Planet Health, 2022; 6, e586−600. doi: 10.1016/S2542-5196(22)00122-X |
| [3] | Yang DH, Chen Y, Meng X, et al. Overweight modified the associations between long-term exposure to ambient fine particulate matter and its constituent and the risk of type 2 diabetes in rural China. Biomed Environ Sci, 2025; 38, 1359−68. |
| [4] | Wang JY, Wang Y, Liang XH, et al. Changes on stroke burden attributable to ambient fine particulate matter in China. Biomed Environ Sci, 2024; 37, 823−33. |
| [5] | Yin P, Luo HH, Gao Y, et al. Criteria air pollutants and diabetes mortality classified by different subtypes and complications: a nationwide, case-crossover study. J Hazard Mater, 2023; 460, 132412. doi: 10.1016/j.jhazmat.2023.132412 |
| [6] | Luo HH, Liu C, Chen XY, et al. Ambient air pollution and hospitalization for type 2 diabetes in China: a nationwide, individual-level case-crossover study. Environ Res, 2023; 216, 114596. doi: 10.1016/j.envres.2022.114596 |
| [7] | Gu JS, Shi Y, Zhu YF, et al. Ambient air pollution and cause-specific risk of hospital admission in China: a nationwide time-series study. PLoS Med, 2020; 17, e1003188. doi: 10.1371/journal.pmed.1003188 |
| [8] | Dales RE, Cakmak S, Vidal CB, et al. Air pollution and hospitalization for acute complications of diabetes in Chile. Environ Int, 2012; 46, 1−5. doi: 10.1016/j.envint.2012.05.002 |
| [9] | He XY, Zhang SP, Bai QL, et al. Air pollution exposure and prevalence of non-alcoholic fatty liver disease and related cirrhosis: a systematic review and meta-analysis. Ecotoxicol Environ Saf, 2025; 289, 117469. doi: 10.1016/j.ecoenv.2024.117469 |
| [10] | Li FR, Liao J, Zhu B, et al. Long-term exposure to air pollution and incident non-alcoholic fatty liver disease and cirrhosis: a cohort study. Liver Int, 2023; 43, 299−307. doi: 10.1111/liv.15416 |
| [11] | Reyes-Caballero H, Rao XQ, Sun QS, et al. Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice. Sci Rep, 2019; 9, 17423. doi: 10.1038/s41598-019-53716-y |
| [12] | Xiao YL, Hu JL, Chen RJ, et al. Impact of fine particulate matter on liver injury: evidence from human, mice and cells. J Hazard Mater, 2024; 469, 133958. doi: 10.1016/j.jhazmat.2024.133958 |
| [13] | Gu WJ, Wang RQ, Chai YX, et al. β3 adrenergic receptor activation alleviated PM2.5-induced hepatic lipid deposition in mice. Sci Total Environ, 2024; 907, 168167. doi: 10.1016/j.scitotenv.2023.168167 |
| [14] | Du XH, Niu Y, Wang CP, et al. Ozone exposure and blood transcriptome: a randomized, controlled, crossover trial among healthy adults. Environ Int, 2022; 163, 107242. doi: 10.1016/j.envint.2022.107242 |
| [15] | Gabehart K, Correll KA, Yang J, et al. Transcriptome profiling of the newborn mouse lung response to acute ozone exposure. Toxicol Sci, 2014; 138, 175−90. doi: 10.1093/toxsci/kft276 |
| [16] | Mutlu GM, Snyder C, Bellmeyer A, et al. Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generation. Am J Respir Cell Mol Biol, 2006; 34, 670−6. doi: 10.1165/rcmb.2005-0329OC |
| [17] | Gao JL, Lei T, Wang HY, et al. Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress. Part Fibre Toxicol, 2022; 19, 64. doi: 10.1186/s12989-022-00505-7 |
| [18] | Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol, 2014; 15, 550. doi: 10.1186/s13059-014-0550-8 |
| [19] | Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc Ser. B Stat Methodol, 1995; 57, 289−300. doi: 10.1111/j.2517-6161.1995.tb02031.x |
| [20] | Rajagopalan S, Park B, Palanivel R, et al. Metabolic effects of air pollution exposure and reversibility. J Clin Invest, 2020; 130, 6034−40. doi: 10.1172/JCI137315 |
| [21] | Liu CQ, Fonken LK, Wang AX, et al. Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes. Part Fibre Toxicol, 2014; 11, 53. doi: 10.1186/s12989-014-0053-5 |
| [22] | Peng C, Bind MAC, Colicino E, et al. Particulate air pollution and fasting blood glucose in nondiabetic individuals: associations and epigenetic mediation in the normative aging study, 2000-2011. Environ Health Perspect, 2016; 124, 1715−21. doi: 10.1289/EHP183 |
| [23] | Brook RD, Xu XH, Bard RL, et al. Reduced metabolic insulin sensitivity following sub-acute exposures to low levels of ambient fine particulate matter air pollution. Sci Total Environ, 2013; 448, 66−71. doi: 10.1016/j.scitotenv.2012.07.034 |
| [24] | Haberzettl P, Mccracken JP, Bhatnagar A, et al. Insulin sensitizers prevent fine particulate matter-induced vascular insulin resistance and changes in endothelial progenitor cell homeostasis. Am J Physiol Heart Circ Physiol, 2016; 310, H1423−38. doi: 10.1152/ajpheart.00369.2015 |
| [25] | Shi CZ, Han X, Mao X, et al. Metabolic profiling of liver tissues in mice after instillation of fine particulate matter. Sci Total Environ, 2019; 696, 133974. doi: 10.1016/j.scitotenv.2019.133974 |
| [26] | Zhang YN, Li YB, Shi ZX, et al. Metabolic impact induced by total, water soluble and insoluble components of PM2.5 acute exposure in mice. Chemosphere, 2018; 207, 337−46. doi: 10.1016/j.chemosphere.2018.05.098 |
| [27] | Zhang YY, Ji XT, Ku T, et al. Ambient fine particulate matter exposure induces cardiac functional injury and metabolite alterations in middle-aged female mice. Environ Pollut, 2019; 248, 121−32. doi: 10.1016/j.envpol.2019.01.080 |
| [28] | Yang SJ, Chen RC, Zhang L, et al. Lipid metabolic adaption to long-term ambient PM2.5 exposure in mice. Environ Pollut, 2021; 269, 116193. doi: 10.1016/j.envpol.2020.116193 |
| [29] | Falk MJ, Gai XW, Shigematsu M, et al. A novel HSD17B10 mutation impairing the activities of the mitochondrial RNase P complex causes X-linked intractable epilepsy and neurodevelopmental regression. RNA Biol, 2016; 13, 477−85. doi: 10.1080/15476286.2016.1159381 |
| [30] | Graves JP, Edin ML, Bradbury JA, et al. Characterization of four new mouse cytochrome P450 enzymes of the CYP2J subfamily. Drug Metab Dispos, 2013; 41, 763−73. doi: 10.1124/dmd.112.049429 |
| [31] | Houten SM, Violante S, Ventura FV, et al. The biochemistry and physiology of mitochondrial fatty acid β-oxidation and its genetic disorders. Annu Rev Physiol, 2016; 78, 23−44. doi: 10.1146/annurev-physiol-021115-105045 |
| [32] | Abu-Elheiga L, Matzuk MM, Abo-Hashema KAH, et al. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science, 2001; 291, 2613−6. doi: 10.1126/science.1056843 |
| [33] | Lau HH, Ng NHJ, Loo LSW, et al. The molecular functions of hepatocyte nuclear factors - In and beyond the liver. J Hepatol, 2018; 68, 1033−48. doi: 10.1016/j.jhep.2017.11.026 |
| [34] | Aslanoglou D, Bertera S, Sánchez-Soto M, et al. Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors. Transl Psychiatry, 2021; 11, 59. doi: 10.1038/s41398-020-01171-z |
| [35] | Liu LS, Wang D, Tang R, et al. Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: a systematic review and meta-analysis. Front Genet, 2022; 13, 959291. doi: 10.3389/fgene.2022.959291 |
| [36] | Lu Y, Qiu WK, Liao RW, et al. Subacute PM2.5 exposure induces hepatic insulin resistance through inflammation and oxidative stress. Int J Mol Sci, 2025; 26, 812. doi: 10.3390/ijms26020812 |
| [37] | Duan XX, Zhang XL, Chen JM, et al. Association of PM2.5 with insulin resistance signaling pathways on a microfluidic liver-kidney microphysiological system (LK-MPS) device. Anal Chem, 2021; 93, 9835−44. doi: 10.1021/acs.analchem.1c01384 |
| [38] | Groeger M, et al. Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages. Nat Commun, 2023; 14, 3902. doi: 10.1038/s41467-023-39311-w |
| [39] | Hirasawa N. Expression of histidine decarboxylase and its roles in inflammation. Int J Mol Sci, 2019; 20, 376. doi: 10.3390/ijms20020376 |
| [40] | Wang C, et al. ATAD2 upregulation promotes tumor growth and angiogenesis in endometrial cancer and is associated with its immune infiltration. Dis Markers, 2022; 2022, 2334338. doi: 10.1155/2022/2334338 |
| [41] | Della Guardia L, Shin AC. PM2.5-induced adipose tissue dysfunction can trigger metabolic disturbances. Trends Endocrinol Metab, 2022; 33, 737−40. doi: 10.1016/j.tem.2022.08.005 |
| [42] | Chen CH, Huang LY, Lee KY, et al. Effects of PM2.5 on skeletal muscle mass and body fat mass of the elderly in Taipei, Taiwan. Sci Rep, 2019; 9, 11176. doi: 10.1038/s41598-019-47576-9 |
| [43] | Liu Y, Li J, Xiong YC, et al. Long-term exposure to PM2.5 leads to mitochondrial damage and differential expression of associated circRNA in rat hepatocytes. Sci Rep, 2024; 14, 11870. doi: 10.1038/s41598-024-62748-y |