Volume 27 Issue 9
Sep.  2014
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LIU Xiao Tong, MU Xi Yan, WU Xiao Li, MENG Li Xuan, GUAN Wen Bi, MA Yong Qiang, SUN Hua, WANG Cheng Ju, LI Xue Feng. Toxicity of Multi-Walled Carbon Nanotubes, Graphene Oxide, and Reduced Graphene Oxide to Zebrafish Embryos[J]. Biomedical and Environmental Sciences, 2014, 27(9): 676-683. doi: 10.3967/bes2014.103
Citation: LIU Xiao Tong, MU Xi Yan, WU Xiao Li, MENG Li Xuan, GUAN Wen Bi, MA Yong Qiang, SUN Hua, WANG Cheng Ju, LI Xue Feng. Toxicity of Multi-Walled Carbon Nanotubes, Graphene Oxide, and Reduced Graphene Oxide to Zebrafish Embryos[J]. Biomedical and Environmental Sciences, 2014, 27(9): 676-683. doi: 10.3967/bes2014.103

Toxicity of Multi-Walled Carbon Nanotubes, Graphene Oxide, and Reduced Graphene Oxide to Zebrafish Embryos

doi: 10.3967/bes2014.103
Funds:  the Specialized Research Fund for the Doctoral Program of Higher Education(200800191013)%the Fundamental Research Funds for the Central Universities
  • Objective This study was aimed to investigate the toxic effects of 3 nanomaterials, i.e. multi-walled carbon nanotubes (MWCNTs), graphene oxide (GO), and reduced graphene oxide (RGO), on zebrafish embryos. Methods The 2-h post-fertilization (hpf) zebrafish embryos were exposed to MWCNTs, GO, and RGO at different concentrations (1, 5, 10, 50, 100 mg/L) for 96 h. Afterwards, the effects of the 3 nanomateria on spontaneous movement, heart rate, hatching rate, length of larvae, mortality, and malformations ls were evaluated. Results Statistical analysis indicated that RGO significantly inhibited the hatching of zebrafish embryos. Furthermore, RGO and MWCNTs decreased the length of the hatched larvae at 96 hpf. No obvious morphological malformation or mortality was observed in the zebrafish embryos after exposure to the three nanomaterials. Conclusion MWCNTs, GO, and RGO were all toxic to zebrafish embryos to influence embryos hatching and larvae length. Although no obvious morphological malformation and mortality were observed in exposed zebrafish embryos, further studies on the toxicity of the three nanomaterials are still needed.
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Toxicity of Multi-Walled Carbon Nanotubes, Graphene Oxide, and Reduced Graphene Oxide to Zebrafish Embryos

doi: 10.3967/bes2014.103
Funds:  the Specialized Research Fund for the Doctoral Program of Higher Education(200800191013)%the Fundamental Research Funds for the Central Universities

Abstract: Objective This study was aimed to investigate the toxic effects of 3 nanomaterials, i.e. multi-walled carbon nanotubes (MWCNTs), graphene oxide (GO), and reduced graphene oxide (RGO), on zebrafish embryos. Methods The 2-h post-fertilization (hpf) zebrafish embryos were exposed to MWCNTs, GO, and RGO at different concentrations (1, 5, 10, 50, 100 mg/L) for 96 h. Afterwards, the effects of the 3 nanomateria on spontaneous movement, heart rate, hatching rate, length of larvae, mortality, and malformations ls were evaluated. Results Statistical analysis indicated that RGO significantly inhibited the hatching of zebrafish embryos. Furthermore, RGO and MWCNTs decreased the length of the hatched larvae at 96 hpf. No obvious morphological malformation or mortality was observed in the zebrafish embryos after exposure to the three nanomaterials. Conclusion MWCNTs, GO, and RGO were all toxic to zebrafish embryos to influence embryos hatching and larvae length. Although no obvious morphological malformation and mortality were observed in exposed zebrafish embryos, further studies on the toxicity of the three nanomaterials are still needed.

LIU Xiao Tong, MU Xi Yan, WU Xiao Li, MENG Li Xuan, GUAN Wen Bi, MA Yong Qiang, SUN Hua, WANG Cheng Ju, LI Xue Feng. Toxicity of Multi-Walled Carbon Nanotubes, Graphene Oxide, and Reduced Graphene Oxide to Zebrafish Embryos[J]. Biomedical and Environmental Sciences, 2014, 27(9): 676-683. doi: 10.3967/bes2014.103
Citation: LIU Xiao Tong, MU Xi Yan, WU Xiao Li, MENG Li Xuan, GUAN Wen Bi, MA Yong Qiang, SUN Hua, WANG Cheng Ju, LI Xue Feng. Toxicity of Multi-Walled Carbon Nanotubes, Graphene Oxide, and Reduced Graphene Oxide to Zebrafish Embryos[J]. Biomedical and Environmental Sciences, 2014, 27(9): 676-683. doi: 10.3967/bes2014.103

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