Articles in press have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).
Development of Public Health for 70 Years
Trends in Lipids Level and Dyslipidemia among Chinese Adults, 2002-2015
Peng Kun SONG, Qing Qing MAN, Hong LI, Shao Jie PANG, Shan Shan JIA, Yu Qian LI, Li HE, Wen Hua ZHAO, Jian ZHANG
2019, 32(8): 559-570.   doi: 10.3967/bes2019.074
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Objective To investigate the trends of lipid profiles and dyslipidemia among Chinese adults from 2002 to 2015. Methods Data were collected from three nationally representative cross-sectional surveys. Fasting venous blood samples were collected and serum lipids were tested by biochemical analysis and enzymatic determination. Lipid levels and the prevalence of dyslipidemia among adults were analyzed with complex sampling weighting adjustment for age and gender. Results The weighted means of TC, TG, and LDL-c significantly increased linearly from 3.93, 1.12, and 2.12 mmol/L in 2002 to 4.59, 1.41, and 2.78 mmol/L in 2010 and then to 4.63, 1.47, and 2.87 mmol/L in 2015, respectively; by contrast, HDL-c levels decreased significantly from 1.30 mmol/L to 1.26 mmol/L over the same period. Similar trends in mean non-HDL-c and lipid-related ratios were observed. The weighted dyslipidemia prevalence linearly increased; in particular, hypercholesterolemia increased from 1.6% to 5.6% and then to 5.8%, hypertriglyceridemia increased from 5.7% to 13.6% and then to 15.0%, low HDL-c increased from 18.8% to 35.5% and then to 24.9%, and high LDL-c increased from 1.3% to 5.6% and then to 7.2% (P for trend < 0.001). Conclusion Dyslipidemia increased among Chinese adults from 2002 to 2015. Development of a comprehensive strategy to decrease lipid levels in this population is urgently required.
Original Articles
Low Calf Circumference Predicts Nutritional Risks in Hospitalized Patients Aged More Than 80 Years
Xiao Yan ZHANG, Xing Liang ZHANG, Yun Xia ZHU, Jun TAO, Zhen ZHANG, Yue ZHANG, Yan Yan WANG, Ying Ying KE, Chen Xi REN, Jun XU, Yuan ZHONG
2019, 32(8): 571-577.   doi: 10.3967/bes2019.075
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Objective The aim of this study wasto determine whether low calf circumference (CC) could predict nutritional risk and the cutoff values of CC for predicting nutritional risk in hospitalized patients aged ≥ 80 years. Methods A total of 1, 234 consecutive patients aged ≥ 80 years were enrolled in this study. On admission, demographic data, CC, and laboratory parameters were obtained. Patients with Nutritional Risk Screening 2002 (NRS-2002) total score ≥ 3 were considered as having nutritional risk. Results CC values were significantly lower in patients with nutritional risk compared to those in patients without nutritional risk[27.00 (24.50-31.00) vs. 31.00 (29.00-33.50], P < 0.001]. CC was negatively correlated with age and nutritional risk scores. Logistic regression analysis of nutritional risk revealed that body mass index, albumin level, hemoglobin level, cerebral infarction, neoplasms, and CC (OR, 0.897; 95% confidence interval, 0.856-0.941; P < 0.001) were independent impact factors of nutritional risk. Nutritional risk scores increased with a decrease in CC. In men, the best CC cutoff value for predicting nutritional risk according to the NRS-2002 was 29.75 cm. In women, the cutoff value was 28.25 cm. Conclusion CC is a simple, noninvasive, and valid anthropometric measure to predict nutritional risk for hospitalized patients aged ≥ 80 years.
Supplementation of Fermented Barley Extracts with Lactobacillus Plantarum dy-1 Inhibits Obesity via a UCP1-dependent Mechanism
Xiang XIAO, Juan BAI, Ming Song LI, Jia Yan ZHANG, Xin Juan SUN, Ying DONG
2019, 32(8): 578-591.   doi: 10.3967/bes2019.076
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Objective We aimed to explore how fermented barley extracts with Lactobacillus plantarum dy-1 (LFBE) affected the browning in adipocytes and obese rats. Methods In vitro, 3T3-L1 cells were induced by LFBE, raw barley extraction (RBE) and polyphenol compounds (PC) from LFBE to evaluate the adipocyte differentiation. In vivo, obese SD rats induced by high fat diet (HFD) were randomly divided into three groups treated with oral gavage:(a) normal control diet with distilled water, (b) HFD with distilled water, (c) HFD with 800 mg LFBE/kg body weight (bw). Results In vitro, LFBE and the PC in the extraction significantly inhibited adipogenesis and potentiated browning of 3T3-L1 preadipocytes, rather than RBE. In vivo, we observed remarkable decreases in the body weight, serum lipid levels, white adipose tissue (WAT) weights and cell sizes of brown adipose tissues (BAT) in the LFBE group after 10 weeks. LFBE group could gain more mass of interscapular BAT (IBAT) and promote the dehydrogenase activity in the mitochondria. And LFBE may potentiate process of the IBAT thermogenesis and epididymis adipose tissue (EAT) browning via activating the uncoupling protein 1 (UCP1)-dependent mechanism to suppress the obesity. Conclusion These results demonstrated that LFBE decreased obesity partly by increasing the BAT mass and the energy expenditure by activating BAT thermogenesis and WAT browning in a UCP1-dependent mechanism.
Effects of Hypoxia on the Growth and Development of the Fetal Ovine Hepatocytes in Primary Culture
Li CAO, Juan WANG, Le BO, Da Wei LI, Na YIN, An Wen ZHOU, Cai Ping MAO
2019, 32(8): 592-601.   doi: 10.3967/bes2019.077
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Objective To investigate the development and characterizations of the hepatocytes isolated from fetal ovine and to determine the effect of hypoxia on their growth and metabolism. Methods Fresh hepatocytes were isolated from the liver of fetal ovine at late gestation, cultured in specific media, and exposed to normoxia (21% O2) or hypoxia (2% O2). The cellular characteristics and population purity were identified by immunocytochemistry and flow cytometry (FCM). The effects of hypoxia on cell cycle and apoptosis of the hepatocytes were evaluated by FCM, whereas the cellular ultrastructure changes were examined with a transmission electron microscope. Results The cell purity of hepatocytes was over 95%. Under hypoxia exposure, the hepatocytes showed a gradual increase in proportion at the S phase and in proliferative index, followed with a compatible increase in apoptosis and progressively decreased cell viability. Additionally, the organelles of the hepatocytes demonstrated dramatic changes, including swelling of mitochondria, disorder in cristae arrangement, expansion of endoplasmic reticulum, and a large number of circular lipid droplets emerging in the cytoplasm. Conclusion Fetal ovine hepatocytes could be primarily cultured in a short-term culture system with a high purity of over 95% and with their preserved original characteristics. Hypoxia could induce changes in ultrastructural and inhibit the proliferation of cultured fetal ovine hepatocytes through apoptotic mechanisms.
Comparative Toxicity of Nanomaterials to Air-blood Barrier Permeability Using an In Vitro Model
Kang Feng ZHAO, Yu Qing SONG, Rui Hua ZHANG, Xiao Yan YANG, Bo SUN, Zhi Quan HOU, Xiao Ping PU, Hong Xing DAI, Xue Tao BAI
2019, 32(8): 602-613.   doi: 10.3967/bes2019.078
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Objective To comparatively study the toxicity of four metal-containing nanoparticles (MNPs) and their chemical counterparts to the air-blood barrier (ABB) permeability using an in vitro model. Methods ABB model, which was developed via the co-culturing of A549 and pulmonary capillary endothelium, was exposed to spherical CuO-NPs (divided into CuO-40, CuO-80, and CuO-100 based on particle size), nano-Al2O3 (sheet and short-rod-shaped), nano-ZnO, nano-PbS, CuSO4, Al2(SO4)3, Zn(CH3COO)2, and Pb(NO3)2 for 60 min. Every 10 min following exposure, the cumulative cleared volume (ΔTCL) of Lucifer yellow by the model was calculated. A clearance curve was established using linear regression analysis of ΔTCL versus time. Permeability coefficient (P) was calculated based on the slope of the curve to represent the degree of change in the ABB permeability. Results The results found the increased P values of CuO-40, CuO-80, sheet, and short-rod-shaped nano-Al2O3, Al2(SO4)3, and Pb(NO3)2. Among them, small CuO-40 and CuO-80 were stronger than CuO-100 and CuSO4; no difference was observed between Al2(SO4)3 and sheet and short-rod-shaped nano-Al2O3; and nano-PbS was slightly weaker than Pb(NO3)2. So clearly the MNPs possess diverse toxicity. Conclusion ABB permeability abnormality means pulmonary toxicity potential. More studies are warranted to understand MNPs toxicity and ultimately control the health hazards.
Power Analysis and Sample Size Determination for Crossover Trials with Application to Bioequivalence Assessment of Topical Ophthalmic Drugs Using Serial Sampling Pharmacokinetic Data
Yong Pei YU, Xiao Yan YAN, Chen YAO, Jie Lai XIA
2019, 32(8): 614-623.   doi: 10.3967/bes2019.079
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Objective To develop methods for determining a suitable sample size for bioequivalence assessment of generic topical ophthalmic drugs using crossover design with serial sampling schemes. Methods The power functions of the Fieller-type confidence interval and the asymptotic confidence interval in crossover designs with serial-sampling data are here derived. Simulation studies were conducted to evaluate the derived power functions. Results Simulation studies show that two power functions can provide precise power estimates when normality assumptions are satisfied and yield conservative estimates of power in cases when data are log-normally distributed. The intra-correlation showed a positive correlation with the power of the bioequivalence test. When the expected ratio of the AUCs was less than or equal to 1, the power of the Fieller-type confidence interval was larger than the asymptotic confidence interval. If the expected ratio of the AUCs was larger than 1, the asymptotic confidence interval had greater power. Sample size can be calculated through numerical iteration with the derived power functions. Conclusion The Fieller-type power function and the asymptotic power function can be used to determine sample sizes of crossover trials for bioequivalence assessment of topical ophthalmic drugs.
Letters to the Editor
Association between Fine Particulate Air Pollution and Outpatient Visits for Eczema in Beijing, China: A Time-series Analysis
Xiao Wen WANG, Yao Hua TIAN, Ya Ying CAO, Jing SONG, Man LI, Yao WU, Meng Ying WANG, Zhe HUANG, Yong Hua HU
2019, 32(8): 624-627.   doi: 10.3967/bes2019.080
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Culturable Bacterial Density and Composition in Haze Events in Xi'an, China
Xiao Hui WANG, Yun Peng WEI, Cheng Cheng LIU, Yu Han WANG, Huan LI, Lin JI, Woodvine OTIENO, Ji Ru XU
2019, 32(8): 628-632.   doi: 10.3967/bes2019.081
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Molecular Epidemiology of Coxsackievirus B1-5 Associated with HFMD in Fujian Province, China, 2011-2016
Wei CHEN, Yu Wei WENG, Yong Jun ZHANG, Wen Xiang HE, Ying ZHU, Ting Ting YU, Jian Feng XIE, Kui Cheng ZHENG, Yan Sheng YAN, Wen Chang ZHANG
2019, 32(8): 633-638.   doi: 10.3967/bes2019.082
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Surveys in Areas of High Risk of Iodine Deficiency and Iodine Excess in China, 2012-2014: Current Status and Examination of the Relationship between Urinary Iodine Concentration and Goiter Prevalence in Children Aged 8-10 Years
Si Lu CUI, Peng LIU, Xiao Hui SU, Shou Jun LIU
2017, 30(2): 88-96.   doi: 10.3967/bes2017.012
[Abstract](13) [FullText HTML](1) [PDF 8383KB](1)
Association between Lipoprotein (a) Levels and Metabolic Syndrome in a Middle-aged and Elderly Chinese Cohort
Xue Yan WU, Lin LIN, Hong Yan Qi, Rui DU, Chun Yan HU, Li Na MA, Kui PENG, Mian LI, Yu XU, Min XU, Yu Hong CHEN, Jie Li LU, Yu Fang BI, Wei Qing WANG, Guang NING
2019, 32(7): 477-485.   doi: 10.3967/bes2019.065
[Abstract](115) [PDF 833KB](2)
Trends in Lipids Level and Dyslipidemia among Chinese Adults, 2002-2015
Peng Kun SONG, Qing Qing MAN, Hong LI, Shao Jie PANG, Shan Shan JIA, Yu Qian LI, Li HE, Wen Hua ZHAO, Jian ZHANG
2019, 32(8): 559-570.   doi: 10.3967/bes2019.074
[Abstract](87) [FullText HTML](2) [PDF 3640KB](2)
Food Frequency Questionnaire for Chinese Children Aged 12-17 Years: Validity and Reliability
Dan LIU, La Hong JU, Zhen Yu YANG, Qian ZHANG, Jian Fen GAO, Di Ping GONG, Dan Dan GUO, Shu Quan LUO, Wen Hua ZHAO
2019, 32(7): 486-495.   doi: 10.3967/bes2019.066
[Abstract](50) [PDF 1877KB](2)
Comparison of Histological, Microbiological, and Molecular Methods in Diagnosis of Patients with TBLN Having Different Anti-TB Treatment Background
Nan Ying CHE, Shao Jun HUANG, Yan MA, Yi HAN, Zi Chen LIU, Chen ZHANG, Jing MU, Dan ZHAO, Yang QU, Hai Qing ZHANG, Zhi Dong LIU, Shao Fa XU
2017, 30(6): 418-425.   doi: 10.3967/bes2017.055
[Abstract](22) [FullText HTML](2) [PDF 2649KB](2)
Prediction of 10-year Atherosclerotic Cardiovascular Disease Risk among Adults Aged 40-79 Years in China: a Nationally Representative Survey
Mei ZHANG, Yong JIANG, LiMin WANG, YiChong LI, ZhengJing HUANG, JianHong LI, MaiGeng ZHOU, WenHua ZHAO
2017, 30(4): 244-254.   doi: 10.3967/bes2017.034
[Abstract](18) [FullText HTML](1) [PDF 2122KB](1)
Supplementation of Fermented Barley Extracts with Lactobacillus Plantarum dy-1 Inhibits Obesity via a UCP1-dependent Mechanism
Xiang XIAO, Juan BAI, Ming Song LI, Jia Yan ZHANG, Xin Juan SUN, Ying DONG
2019, 32(8): 578-591.   doi: 10.3967/bes2019.076
[Abstract](61) [FullText HTML](2) [PDF 9100KB](2)
Preliminary Study on Drug Susceptibility Profile and Resistance Mechanisms to Macrolides of Clinical Isolates of Non-tuberculous Mycobacteria from China
Fu LI, Gui Lian LI, Hui PANG, Hai Can LIU, Tong Yang XIAO, Shuang Jun LI, Qiao LUO, Yi JIANG, Rui Bai WANG, Kang Lin WAN
2018, 31(4): 290-299.   doi: 10.3967/bes2018.037
[Abstract](43) [FullText HTML](1) [PDF 7257KB](1)
A Reverse-transcription Recombinase-aided Amplification Assay for the Rapid Detection of the Far-Eastern Subtype of Tick-borne Encephalitis Virus
Qian Ying WANG, Fan LI, Xin Xin SHEN, Shi Hong FU, Ying HE, Wen Wen LEI, Guo Dong LIANG, Huan Yun WANG, Xue Jun MA
2019, 32(5): 357-362.   doi: 10.3967/bes2019.047
[Abstract](55) [FullText HTML](2) [PDF 479KB](2)
Maternal Lead Exposure Induces Down-regulation of Hippocampal Insulin-degrading Enzyme and Nerve Growth Factor Expression in Mouse Pups
Xing LI, Ning LI, Hua Lei SUN, Jun YIN, Yu Chang TAO, Zhen Xing MAO, Zeng Li YU, Wen Jie LI, D BOGDEN John
2017, 30(3): 215-219.   doi: 10.3967/bes2017.029
[Abstract](18) [FullText HTML](2) [PDF 1170KB](2)
Handgrip Strength as a Predictor of Nutritional Status in Chinese Elderly Inpatients at Hospital Admission
Xin Sheng ZHANG, Ying Hua LIU, Yong ZHANG, Qing XU, Xiao Ming YU, Xue Yan YANG, Zhao LIU, Hui Zi LI, Feng LI, Chang Yong XUE
2017, 30(11): 802-810.   doi: 10.3967/bes2017.108
[Abstract](22) [FullText HTML](1) [PDF 8447KB](1)
Prognostic Value of NT-proBNP in Stable Coronary Artery Disease in Chinese Patients after Percutaneous Coronary Intervention in the Drug-eluting Stent Era
Xue Yan ZHAO, Jian Xin LI, Xiao Fang TANG, Jing Jing XU, Ying SONG, Lin JIANG, Jue CHEN, Lei SONG, Li Jian GAO, Zhan GAO, Shu Bin QIAO, Yue Jin YANG, Run Lin GAO, Bo XU, Jin Qing YUAN
2018, 31(12): 859-866.   doi: 10.3967/bes2018.117
[Abstract](49) [FullText HTML](0) [PDF 507KB](0)
Microwave-induced Apoptosis and Cytotoxicity of NK Cells through ERK1/2 Signaling
Li ZHAO, Jing LI, Yan Hui HAO, Ya Bing GAO, Shui Ming WANG, Jing ZHANG, Ji DONG, Hong Mei ZHOU, Shu Chen LIU, Rui Yun PENG
2017, 30(5): 323-332.   doi: 10.3967/bes2017.043
[Abstract](18) [FullText HTML](0) [PDF 3416KB](0)
Combined Effects of A Body Shape Index and Serum C-reactive Protein on Ischemic Stroke Incidence among Mongolians in China
Guang Li WANG, Rui ZHANG, Yi Ting ZHOU, Ai Li WANG, Tian XU, Ming Zhi ZHANG, Hong Mei LI, Yong Hong ZHANG
2019, 32(3): 169-176.   doi: 10.3967/bes2019.024
[Abstract](53) [FullText HTML](1) [PDF 5430KB](1)
The Impacts of Simulated Microgravity on Rat Brain Depended on Durations and Regions
Bo CHEN, Yu Shi ZHANG, George LI, Jun-Lae CHO, Yu Lin DENG, Yu Juan LI
2019, 32(7): 496-507.   doi: 10.3967/bes2019.067
[Abstract](94) [PDF 1618KB](2)
Molecular Epidemiology of Coxsackievirus B1-5 Associated with HFMD in Fujian Province, China, 2011-2016
Wei CHEN, Yu Wei WENG, Yong Jun ZHANG, Wen Xiang HE, Ying ZHU, Ting Ting YU, Jian Feng XIE, Kui Cheng ZHENG, Yan Sheng YAN, Wen Chang ZHANG
2019, 32(8): 633-638.   doi: 10.3967/bes2019.082
[Abstract](42) [FullText HTML](2) [PDF 3245KB](2)
Power Analysis and Sample Size Determination for Crossover Trials with Application to Bioequivalence Assessment of Topical Ophthalmic Drugs Using Serial Sampling Pharmacokinetic Data
Yong Pei YU, Xiao Yan YAN, Chen YAO, Jie Lai XIA
2019, 32(8): 614-623.   doi: 10.3967/bes2019.079
[Abstract](45) [FullText HTML](2) [PDF 38332KB](2)
Nosocomial Infection Surveillance in a Tuberculosis Specialized Hospital in China
Zhong Yao XIE, Guo Fang HUANG, Hui GAO, Yu Qing CHI, Yan Xia WANG, Yu PANG, Jing Ping WANG
2017, 30(9): 691-694.   doi: 10.3967/bes2017.093
[Abstract](21) [FullText HTML](1) [PDF 649KB](1)
Association of PPARγ and AGTR1 Polymorphisms with Hypertriglyceridemia in Chinese Population
Yi DING, Dao Xia GUO, Yang JING, Jie WANG, Chong SHEN, Hui ZHOU, Chen DONG
2018, 31(8): 619-622.   doi: 10.3967/bes2018.084
[Abstract](38) [FullText HTML](0) [PDF 3613KB](0)
LncRNA H19 and Target Gene-mediated Cleft Palate Induced by TCDD
Li Yun GAO, Feng Quan ZHANG, WEI Hui ZHAO, Guang Liang HAN, Xiao WANG, Qiang LI, Shan Shan GAO, Wei Dong WU
2017, 30(9): 676-680.   doi: 10.3967/bes2017.090
[Abstract](14) [FullText HTML](2) [PDF 1060KB](2)

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Current Issue

Vol 32, No 8

(September, 2019)

ISSN 0895-3988

CN 11-2816 / Q

  • 2018 Impact Factor 2.518

  • 2018 Journal Citation Reports