Articles in press have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).
2020, 33(9): 0-0.  
HTML Full Text PDF 5274KB
2020, 33(9): 1-2.  
HTML Full Text PDF 145KB
Original Article
Acute Effects of Individual Exposure to Fine Particulate Matter on Pulmonary Function in Schoolchildren
YANG Xiao Yan, WEN Bo, HAN Feng, WANG Chong, ZHANG Shao Ping, WANG Jun, XU Dong Qun, WANG Qin
2020, 33(9): 647-659.   doi: 10.3967/bes2020.086
HTML Full Text PDF 5400KB
  Objective  This panel study aimed to determine the acute effects of exposure to fine particulate matter (PM2.5) on schoolchildren’s pulmonary function.  Methods  We selected 51 schoolchildren aged 9–12 years attending a full-time boarding school in Beijing, China, measured the indoor and outdoor PM2.5 concentrations for five consecutive days, calculated the PM2.5 time-weighted individual exposure levels based on the school micro-environmental concentrations and the time activity pattern recorded by schoolchildren, measured schoolchildren’s pulmonary function on the fifth day. The survey was performed three times from December 2018 to April 2019. We used a linear mixed-effects model to evaluate the associations between PM2.5 and pulmonary function.  Results  During the three surveys, the median PM2.5 time-weighted individual exposure concentrations were 15.30 μg/m3, 48.92 μg/m3, and 42.89 μg/m3, respectively. There was a significant difference between the three surveys in vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and forced expiratory volume in one second/forced vital capacity (FEV1/FVC) (P < 0.05). The relevance analysis found that PM2.5 had lag effect on schoolchildren’s pulmonary function, each 10 μg/m3 increase in PM2.5 could cause largest decreases in FEF25%–75%, FEV1/FVC, FEF75%, and FEV1 on lag 0–1 d (80.44 mL/s, 35.85%, 78.58 mL/s, and 61.34 mL, respectively), and largest decreases in FEF25% on lag 1 d (83.68 mL/s), in VC on lag 4 d (32.34 mL), and in FVC on lag 0–4 d (37.76 mL). Gender subgroup analysis revealed that the increase in PM2.5 caused a decrease in FEV1/FVC and VC on the day of physical examination only in boys, and on lag days it caused changes in different pulmonary function indicators, both for boys and girls, but most of the pulmonary function indicators decreased more in boys than in girls.  Conclusion  Our findings show that acute PM2.5 exposure has significant effects on pulmonary function within 0–4 d, on both small airway indicators and large airway indicators. Boys’ pulmonary function is more sensitive to PM2.5 than girls.
Sociodemographic Factors Associated with Dietary Intake of Thiamine, Riboflavin, and Niacin among Chinese Adults in 2015
LI Li, ZHANG Bing, WANG Hui Jun, OUYANG Yi Fei, HUANG Fei Fei, WANG Yun, ZHANG Ji Guo, SU Chang, DU Wen Wen, JIA Xiao Fang, JIANG Hong Ru, WANG Zhi Hong
2020, 33(9): 660-669.   doi: 10.3967/bes2020.087
HTML Full Text PDF 1091KB
  Objective  To estimate the association between three B-vitamin intakes and sociodemographic factors among adults in China.  Methods  We derived our data from the China Health and Nutrition Survey (CHNS) among 12,241 individuals aged 18–64 years. Log binomial regression was used to estimate adjusted prevalence ratios for factors associated with the inadequate intake of B-vitamins.  Results  Females with low incomes and living in the north had a higher prevalence of inadequate riboflavin intake than those with high incomes and living in the south. Both males and females living in a village had a higher prevalence of inadequate riboflavin intake than adults living in a city. Adults with low income, low education, and living in the north or in a village had a higher prevalence of inadequate niacin intake than adults with a high income, high education, and living in the south or in a city.  Conclusion  We found that income, region, and area of residence were associated with riboflavin intake. Education, income, region, and area of residence were associated with niacin intake. Well-tailored strategies and policies are needed to improve nutritional status in China.
Development and Assessment of Two Highly Pathogenic Avian Influenza (HPAI) H5N6 Candidate Vaccine Viruses for Pandemic Preparedness
LIU Li Qi, LI Zi, JIAO Ming, LU Jian, ZHOU Jian Fang, LI Xi Yan, LIU Jia, GUO Jun Feng, XIAO Ning, ZHAO Xiang, WANG Da Yan
2020, 33(9): 670-679.   doi: 10.3967/bes2020.088
HTML Full Text PDF 9460KB
  Objective  In China, 24 cases of human infection with highly pathogenic avian influenza (HPAI) H5N6 virus have been confirmed since the first confirmed case in 2014. Therefore, we developed and assessed two H5N6 candidate vaccine viruses (CVVs).  Methods  In accordance with the World Health Organization (WHO) recommendations, we constructed two reassortant viruses using reverse genetics (RG) technology to match the two different epidemic H5N6 viruses. We performed complete genome sequencing to determine the genetic stability. We assessed the growth ability of the studied viruses in MDCK cells and conducted a hemagglutination inhibition assay to analyze their antigenicity. Pathogenicity attenuation was also evaluated in vitro and in vivo.  Results  The results showed that no mutations occurred in hemagglutinin or neuraminidase, and both CVVs retained their original antigenicity. The replication capacity of the two CVVs reached a level similar to that of A/Puerto Rico/8/34 in MDCK cells. The two CVVs showed low pathogenicity in vitro and in vivo, which are in line with the WHO requirements for CVVs.  Conclusion  We obtained two genetically stable CVVs of HPAI H5N6 with high growth characteristics, which may aid in our preparedness for a potential H5N6 pandemic.
Proteomics Study on the Differentially Expressed Proteins in c-fos-silenced Cells Exposed to PM2.5
CAI Ying, ZHENG Kai, LI Run Bing, YU Shu Yuan, LIU Ning, JI Jia Jia, YANG Chen, WU De Sheng, QIN Shuang Jian, LI Bo Ru, ZHANG Zhao Hui, XU Xin Yun
2020, 33(9): 680-689.   doi: 10.3967/bes2020.089
HTML Full Text PDF 20315KB
  Objective  To investigate the effect of c-fos gene silencing on differentially expressed proteins (DEPs) in human bronchial epithelial (HBE) cells after exposure to fine particulate matter (PM2.5).  Methods  HBE cells and c-fos-silenced HBE cells were exposed to 50 μg/mL PM2.5, LC-MS/MS and tandem mass tag (TMT) labeling methods were combined with bioinformatics methods, and DEPs and interaction networks were identified.  Results  In the HBE group, 414 DEPs were screened, of which 227 were up-regulated and 187 down-regulated. In the c-fos silenced HBE group, 480 DEPs were screened, including 240 up-regulated proteins and 240 down-regulated proteins. KEGG annotations showed that DEPs in the HBE group are mainly concentrated in the glycolysis/gluconeogenesis pathway and those in the c-fos silenced group are concentrated mainly in endoplasmic reticulum and the processing of proteins. Additionally, the abnormal expression of GPRC5C, DKK4, and UBE2C was identified in top 15 DEPs. After constructing the protein interaction network, 20 Hub proteins including HNRNPA2B1, HNRNPL, RPS15A, and RPS25 were screened from the HBE group and the c-fos silenced HBE group.  Conclusion  c-fos gene affected the expression of cancer-related proteins. Our results provided a scientific basis for further study of PM2.5-induced carcinogenesis mechanism.
Silymarin Attenuates Hepatic and Pancreatic Redox Imbalance Independent of Glycemic Regulation in the Alloxan-induced Diabetic Rat Model
Miranda Laise Mara Oliveira, Agostini Lívia da Cunha, Lima Wanderson Geraldo de, Camini Fernanda Caetano, Costa Daniela Caldeira
2020, 33(9): 690-700.   doi: 10.3967/bes2020.090
HTML Full Text PDF 29881KB
  Objective  To evaluate the efficiency of silymarin (SMN) in modulating metabolic parameters and redox status in rats with type 1 diabetes mellitus (T1DM).  Methods  Diabetes was induced by intraperitoneal injection of alloxan. The diabetic rats were administered with SMN at doses of 50 and 100 mg/kg body weight/d for 30 consecutive days. The rats were divided into the following four groups: vehicle control, diabetic (alloxan-treated), DS50 (alloxan + 50 mg/kg body weight/d of SMN), and DS100 (alloxan + 100 mg/kg body weight/d of SMN) groups. The bodyweight and food and water intake were evaluated. After 30 d, the animals were euthanized and the blood was collected for measuring the serum levels of glucose, triacylglycerol (TAG), urea, and creatinine. The liver and pancreas were collected for measuring the activities of superoxide dismutase (SOD) and catalase (CAT), and the levels of carbonylated protein (PC). The pancreas sample was also used for histological analysis.  Results  SMN reduced hepatic (P < 0.001) and pancreatic (P < 0.001) protein damage and creatinine levels (P = 0.0141) in addition to decreasing food (P < 0.001) and water intake (P < 0.001). However, treatment with SMN did not improve beta-cell function or decrease blood glucose levels in diabetic rats.  Conclusion  SMN improved polyphagia and polydipsia, renal function, and protected the liver and pancreas against protein damage without affecting hyperglycemia in diabetic animals.
Association between Mean Ocular Perfusion Pressure and Diabetic Retinopathy in a Northeastern Chinese Population
ZHAI Gang, LIN Zhong, WANG Feng Hua, WANG Yu, LI Dong, WEN Liang, DING Xiao Xia, JIANG Jing, FENG Ke Mi, LIANG Yuan Bo, XIE Cong
2020, 33(9): 701-707.   doi: 10.3967/bes2020.091
HTML Full Text PDF 1097KB
  Objective  To evaluate the association between diabetic retinopathy (DR) and mean ocular perfusion pressure (MOPP) in patients with type 2 diabetes mellitus (T2DM).  Methods  Patients from the Fushun Diabetic Retinopathy Cohort Study (FS-DIRECT), a community-based prospective cohort study conducted in northeast China, were included in this study. The presence and severity of DR were determined by grading fundus photographs according to the Early Treatment Diabetic Retinopathy Study (ETDRS) retinopathy scale. Systolic and diastolic blood pressure (SBP and DBP) were recorded using an electronic sphygmomanometer. Intraocular pressure (IOP) was measured using an iCare rebound tonometer. MOPP was calculated using the formula MOPP = 2/3 [DBP + 1/3 (SBP − DBP)] − IOP.  Results  In total, 1,857 patients who had gradable fundus photography and MOPP data were enrolled in this study. Male patients had a higher MOPP than female patients (52.25 ± 8.75 vs. 50.96 ± 8.74 mmHg, P = 0.002). Overall, both male and female patients with any type of DR, non-proliferative DR (NPDR), or non-sight-threatening DR (non-STDR) had significantly higher MOPP relative to patients without DR. Increased MOPP (per 1 mmHg) was in turn associated with the presence of any type of DR [odds ratio (OR) = 1.03, 95% confidence interval (CI) : 1.02–1.04], NPDR (OR = 1.03 95% CI: 1.02–1.04), and non-STDR (OR = 1.03, 95% CI: 1.01–1.04) after adjusting for confounders. Increased MOPP (per 1 mmHg) was also associated with an increased likelihood of macular edema (OR = 1.02, 95% CI: 1.01–1.04).  Conclusions  The results suggest that increased MOPP was associated with DR and macular edema in northeastern Chinese patients with T2DM.
Letter to the Editor
The SOST (Sclerostin) Gene +219 Site Methylation is the Risk Factor of Acute Cerebral Ischemia in the Han Chinese Population: A Case-control Study
YIN Yi Hong, HU Wei, ZHU Zheng Yu, HAN Min, XIE Zhao Hong, BI Jian Zhong
2020, 33(9): 708-712.   doi: 10.3967/bes2020.092
HTML Full Text PDF 10219KB
Anti-cancer Effect of 20(S)-Ginsenoside-Rh2 on Oral Squamous Cell Carcinoma Cells via the Decrease in ROS and Downregulation of MMP-2 and VEGF
ZHANG Bao Ping, LI Bo, CHENG Jing Yang, CAO Rui, GAO Shu Ting, HUANG Chun Juan, LI Rui Ping, NING Jing, LIU Bin, LI Zhi Ge
2020, 33(9): 713-717.   doi: 10.3967/bes2020.093
HTML Full Text PDF 37062KB
Diagnosis of Early Esophageal Cancer Based on TCM Tongue Inspection
SONG An Yi, LOU Yan Ni, YANG Qian Xi, LI Dong Fang, SONG Guo Hui, HUANG Lai Qiang, YUAN Ke Hong, JIA Li Qun
2020, 33(9): 718-722.   doi: 10.3967/bes2020.094
HTML Full Text PDF 21931KB
Preparation of N-chloramine-Decorated AgCl Nanoparticles with Enhanced Bactericidal Activity
XU Jia Rong, ZHAO Yan Bao
2020, 33(9): 723-726.   doi: 10.3967/bes2020.095
HTML Full Text PDF 18836KB
Modification of Proliferation and Morphology in Human Umbilical Vein Endothelial Cells via in vitro High-Frequency, Low-Energy, Linear-Focused, Continuous Ultrasound Stimulation
SUN An Yu, LAI Jiao Jiao, DU Hui Lin
2020, 33(9): 727-730.   doi: 10.3967/bes2020.096
HTML Full Text PDF 39442KB
Determination of Fipronil and Its Metabolites in Eggs by Indirect Competitive ELISA and Lateral-flow Immunochromatographic Strip
ZHOU Xing Hua, ZHANG Cai Qin, ZHANG Xun, SUN Cheng, LI Jie, XIAO Xiang, ZHAO Yan Sheng, OUYANG Qin, WANG Yun
2020, 33(9): 731-734.   doi: 10.3967/bes2020.097
HTML Full Text PDF 4684KB
The Serum Exosome Derived MicroRNA-135a, -193b, and-384 Were Potential Alzheimer's Disease Biomarkers
YANG Ting Ting, LIU Chen Geng, GAO Shi Chao, ZHANG Yi, WANG Pei Chang
2018, 31(2): 87-96.   doi: 10.3967/bes2018.011
[Abstract](2997) [FullText HTML](389) [PDF 11333KB](389)
Stability of SARS Coronavirus in Human Specimens and Environment and Its Sensitivity to Heating and UV Irradiation
2003, 16(3): 246-255.  
[Abstract](4163) [PDF 610KB](401)
Bone Injury and Fracture Healing Biology
Ahmad Oryan, Somayeh Monazzah, Amin Bigham-Sadegh
2015, 28(1): 57-71.   doi: 10.3967/bes2015.006
[Abstract](1939) [PDF 3875KB](434)
Resveratrol Induces Apoptosis and Autophagy in T-cell Acute Lymphoblastic Leukemia Cells by Inhibiting Akt/mTOR and Activating p38-MAPK
GE Jiao, LIU Yan, LI Qiang, GUO Xia, GU Ling, MA Zhi Gui, ZHU Yi Ping
2013, 26(11): 902-911.   doi: 10.3967/bes2013.019
[Abstract](2266) [PDF 12143KB](167)
Inactivation of Poliovirus by Ozone and the Impact of Ozone on the Viral Genome
JIANG Han Ji, CHEN Na, SHEN Zhi Qiang, YIN Jing, QIU Zhi Gang, MIAO Jing, YANG Zhong Wei, SHI Dan Yang, WANG Hua Ran, WANG Xin Wei, LI Jun Wen, YANG Dong, JIN Min
2019, 32(5): 324-333.   doi: 10.3967/bes2019.044
[Abstract](2152) [FullText HTML](225) [PDF 2666KB](225)
An Evaluation of the Investment for Child Development in China
ZHENG Xiao Ying, CHEN Chun Ming, HUANG Cheng Li, Han You Li, QIU Yue, ZHANG Qian Deng, CHEN He
2012, 25(4): 413-420.   doi: 10.3967/0895-3988.2012.04.006
[Abstract](1894) [PDF 183KB](138)
Metabolomic Profiling Differences among Asthma, COPD, and Healthy Subjects: A LC-MS-based Metabolomic Analysis
LIANG Ying, GAI Xiao Yan, CHANG Chun, ZHANG Xu, WANG Juan, LI Ting Ting
2019, 32(9): 659-672.   doi: 10.3967/bes2019.085
[Abstract](2231) [FullText HTML](259) [PDF 2914KB](259)
Analysis of Protoscoleces-specific Antigens from Echinococcus Granulosus with Proteomics Combined with Western Blot
LI Zong Ji, ZHAO Wei
2012, 25(6): 718-723.   doi: 10.3967/0895-3988.2012.06.015
[Abstract](1778) [PDF 279KB](139)
A Study of the Technique of Western Blot for Diagnosis of Lyme Disease caused by Borrelia afzelii in China
LIU Zhi Yun, HAO Qin, HOU Xue Xia, JIANG Yi, GENG Zhen, WU Yi Mou, WAN Kang Lin
2013, 26(3): 190-200.   doi: 10.3967/0895-3988.2013.03.006
[Abstract](2061) [PDF 9794KB](177)
Outline of the Report on Cardiovascular Disease in China, 2010
HU Sheng Shou, KONG Ling Zhi, GAO Run Lin, ZHU Man Lu, WANG Wen, WANG Yong Jun, WU Zhao Su, CHEN Wei Wei, LIU Ming Bo
2012, 25(3): 251-256.   doi: 10.3967/0895-3988.2012.03.001
[Abstract](2729) [PDF 2961KB](180)
Evaluating the Nutritional Status of Oncology Patientsand Its Association with Quality of Life
ZHANG Ya Hui, XIE Fang Yi, CHEN Ya Wen, WANG Hai Xia, TIAN Wen Xia, SUN Wen Guang, WU Jing
2018, 31(9): 637-644.   doi: 10.3967/bes2018.088
[Abstract](2575) [FullText HTML](237) [PDF 31943KB](237)
Viral and Bacterial Etiology of Acute Febrile Respiratory Syndrome among Patients in Qinghai, China
LIU Gao Shan, LI Hong, ZHAO Sheng Cang, LU Rou Jian, NIU Pei Hua, TAN Wen Jie
2019, 32(6): 438-445.   doi: 10.3967/bes2019.058
[Abstract](2295) [PDF 10063KB](228)
Predictive Values of Body Mass Index and Waist Circumference for Risk Factors of Certain Related Diseases in Chinese Adults - Study on Optimal Cut-off Points of Body Mass Index and Waist Circumference in Chinese Adults
ZHOU Bei-fan
2002, 15(1): 83-96.  
[Abstract](2044) [PDF 551KB](156)
Interpretation Criteria for Standardized Western Blot for the Predominant Species of Borrelia Burgdorferi Sensu Lato in China
2010, 23(5): 341-349.  
[Abstract](2010) [PDF 314KB](147)
Paraben Content in Adjacent Normal-malignant Breast Tissues from Women with Breast Cancer
Mohammad Mehdi Amin, Maryam Tabatabaeian, Afsane Chavoshani, Elham Amjadi, Majid Hashemi, Karim Ebrahimpour, Roya Klishadi, Sedigheh Khazaei, Marjan Mansourian
2019, 32(12): 893-904.   doi: 10.3967/bes2019.112
[Abstract](1500) [FullText HTML](205) [PDF 2461KB](205)
Supplementation of Fermented Barley Extracts with Lactobacillus Plantarum dy-1 Inhibits Obesity via a UCP1-dependent Mechanism
XIAO Xiang, BAI Juan, LI Ming Song, ZHANG Jia Yan, SUN Xin Juan, DONG Ying
2019, 32(8): 578-591.   doi: 10.3967/bes2019.076
[Abstract](2595) [FullText HTML](216) [PDF 9101KB](216)
Exposure Effects of Terahertz Waves on Primary Neurons and Neuron-like Cells Under Nonthermal Conditions
TAN Sheng Zhi, TAN Peng Cheng, LUO Lan Qing, CHI Yun Liang, YANG Zi Long, ZHAO Xue Long, ZHAO Li, DONG Ji, ZHANG Jing, YAO Bin Wei, XU Xin Ping, TIAN Guang, CHEN Jian Kui, WANG Hui, PENG Rui Yun
2019, 32(10): 739-754.   doi: 10.3967/bes2019.094
[Abstract](1566) [FullText HTML](177) [PDF 3322KB](177)
Report on Childhood Obesity in China (9): Sugar-sweetened Beverages Consumption and Obesity
SHANG Xian Wen, LIU Ai Ling, ZHANG Qian, HU Xiao Qi, DU Song Ming, MA Jun, XU Gui Fa, LI Ying, GUO Hong Wei, DU Lin, LI Ting Yu, MA Guan Sheng
2012, 25(2): 125-132.   doi: 10.3967/0895-3988.2012.02.001
[Abstract](2031) [PDF 460KB](155)
Burden of Cirrhosis and Other Chronic Liver Diseases Caused by Specific Etiologies in China, 1990−2016: Findings from the Global Burden of Disease Study 2016
LI Man, WANG Zhuo Qun, ZHANG Lu, ZHENG Hao, LIU Dian Wu, ZHOU Mai Geng
2020, 33(1): 1-10.   doi: 10.3967/bes2020.001
[Abstract](2053) [FullText HTML](178) [PDF 2552KB](178)
Evaluation of Effectiveness of Integrated Intervention Program in Improving Drug Addicts' Psychological Health1
2008, 21(1): 75-84.  
[Abstract](1589) [PDF 0KB](131)

ScholarOne Manuscripts Log In

Register here login in

Current Issue

Vol 33, No 9

(September, 2020)

ISSN 0895-3988

CN 11-2816/Q

  • 2019 Impact Factor 2.656

  • 2019 Journal Citation Reports