Current Articles

Cover
2020, 33(12): 0-0.
Contents
2020, 33(12): 1-2.
Original Article
Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China
MA Yan, ZHU Dong Shan, CHEN Ren Bo, SHI Nan Nan, LIU Si Hong, FAN Yi Pin, WU Gui Hui, YANG Pu Ye, BAI Jiang Feng, CHEN Hong, CHEN Li Ying, FENG Qiao, GUO Tuan Mao, HOU Yong, HU Gui Fen, HU Xiao Mei, HU Yun Hong, HUANG Jin, HUANG Qiu Hua, HUANG Shao Zhen, JI Liang, JIN Hai Hao, LEI Xiao, LI Chun Yan, LI Min Qing, LI Qun Tang, LI Xian Yong, LIU Hong De, LIU Jin Ping, LIU Zhang, MA Yu Ting, MAO Ya, MO Liu Fen, NA Hui, WANG Jing Wei, SONG Fang Li, SUN Sheng, WANG Dong Ting, WANG Ming Xuan, WANG Xiao Yan, WANG Yin Zhen, WANG Yu Dong, WU Wei, WU Lan Ping, XIAO Yan Hua, XIE Hai Jun, XU Hong Ming, XU Shou Fang, XUE Rui Xia, YANG Chun, YANG Kai Jun, YUAN Sheng Li, ZHANG Gong Qi, ZHANG Jin Bo, ZHANG Lin Song, ZHAO Shu Sen, ZHAO Wan Ying, ZHENG Kai, ZHOU Ying Chun, ZHU Jun Teng, ZHU Tian Qing, ZHANG Hua Min, WANG Yan Ping, WANG Yong Yan, on behalf of 'Lung cleansing & detoxifying decoction' Emergency Project Expert Group for COVID-19
2020, 33(12): 893-905. doi: 10.3967/bes2020.123
  Objective   Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.   Methods   A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio (OR) and 95% confidence interval (95% CI) of the associations between comorbidities (cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.   Results   Overall, 158 (13.6%) patients were diagnosed with severe illness and 32 (2.7%) had unfavorable outcomes. Hypertension (2.87, 1.30–6.32), type 2 diabetes (T2DM) (3.57, 2.32–5.49), cardiovascular disease (CVD) (3.78, 1.81–7.89), fatty liver disease (7.53, 1.96–28.96), hyperlipidemia (2.15, 1.26–3.67), other lung diseases (6.00, 3.01–11.96), and electrolyte imbalance (10.40, 3.00–26.10) were independently linked to increased odds of being severely ill. T2DM (6.07, 2.89–12.75), CVD (8.47, 6.03–11.89), and electrolyte imbalance (19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission (5.46, 3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes (6.58, 1.46–29.64) within two weeks.   Conclusion   Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.
Comparison of Clinical Characteristics and Outcomes of Pediatric and Adult Patients with Coronavirus Disease 2019 in Shenzhen, China
WANG Fang, LAI Chang Xiang, HUANG Peng Yu, LIU Jia Ming, WANG Xian Feng, TANG Qi Yuan, ZHOU Xuan, XIAN Wen Jie, CHEN Rui Kun, LI Xuan, LI Zhi Yu, LIAO Li Qun, HE Qing, LIU Lei
2020, 33(12): 906-915. doi: 10.3967/bes2020.124
  Objective  Here we aimed to investigate the difference in clinical characteristics and outcomes between pediatric and adult patients with COVID-19.  Methods  A total of 333 consecutive patients with laboratory-confirmed SARS-CoV-2 infection treated in the departments of Internal medicine of Shenzhen Third People's Hospital from January 11th to February 10th, 2020 were included. The data were obtained from electronic medical records. The epidemiological data, clinical characteristics, length of hospital stays, and outcomes of pediatric and adult patients were compared.  Results  Compared with adult patients, pediatric patients had a shorter time of symptom onset to hospitalization than adults [median time, 1 (IQR, 1.0–1.0) d vs. 3 (IQR, 2.0–6.0) d, P < 0.001], milder or fewer symptoms, less severe chest CT findings. The clinical severity classification of children was less severe than adults. Up to 15th March, the end of the follow-up, 33 (100%) children and 292 (97.3%) adult patients had been discharged from hospital. Only 2 (0.7%) adult patients died, with an overall case mortality of 0.6%. The median length of hospital stay of pediatric patients was shorter than that of adult patients [19 (95% CI: 16.6–21.4) d vs. 21 (95% CI: 19.9–22.1) d, P = 0.024].  Conclusion  Pediatric patients with COVID-19 had milder or less clinical symptoms, less evident pulmonary imaging changes, better prognosis, and shorter length of hospital stay.
Mycoplasma pneumoniae Macrolide Resistance and MLVA Typing in Children in Beijing, China, in 2016: Is It Relevant?
DOU Hai Wei, TIAN Xiu Jun, XIN De Li, WEI Ran, ZHOU Wei, WANG Hong, QIN Xuan Guang, SHAO Jun Yan, XU Bao Ping, GE Li Xia, SHI Da Wei
2020, 33(12): 916-924. doi: 10.3967/bes2020.125
  Objective  The aim of this study is to investigate the macrolide resistance rate and molecular type with multiple-locus variable-number tandem-repeat analysis (MLVA) of Mycoplasma pneumoniae of Beijing in 2016 in pediatric patients.  Methods  Real-time quantitative polymerase chain reaction (PCR) was used to identify M. pneumoniae, and MLVA was performed. The domain V of the 23S rRNA was sequenced to detect macrolide-resistant point mutations. We also investigated the activities of antibiotics against M. pneumoniae isolates in vitro.  Results  The PCR detection rate of M. pneumoniae in children in Beijing was 40%, and the macrolide resistance rate was 66%. The A2063G mutation in the 23S rRNA V region is the dominant mutation (137/146, 93.84%), whereas the A2064G mutation is rare (9/146, 6.16%). Seventy-three samples were typed successfully by MLVA typing, including 86.3% (63/73) were MLVA type 4-5-7-2, and 13.7% (10/73) were MLVA type 3-5-6-2. No other types were found. No strains were resistant to levofloxacin or tetracycline.  Conclusion  In 2016, a specific decrease in the macrolide resistance rate occurred in Beijing. The detection rate and macrolide resistance rate of outpatients are lower than those of inpatients. The A2063G mutants M. pneumoniae have high levels of resistance to erythromycin and azithromycin. The primary MLVA type is 4-5-7-2, followed by 3-5-6-2. No other MLVA types were detected. No strains resistant to tetracycline or levofloxacin were found in vitro.
Letter to the Editor
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Contamination of High-touch Surfaces in Field Settings
Sahar Gholipour, Mahnaz Nikaeen, Reza Mohammadi Manesh, Shima Aboutalebian, Zahra Shamsizadeh, Elahe Nasri, Hossein Mirhendi
2020, 33(12): 925-929. doi: 10.3967/bes2020.126
Pulmonary Nodules Developed Rapidly in Staffs in the Isolation Ward of a Chinese Hospital during the COVID-19 Epidemic
LI Yu Hua, YU Ke Wen, SUN Neng Jun, JIN Xiao Dong, LUO Xin, YANG Jing, HE Bing, LI Bo
2020, 33(12): 930-934. doi: 10.3967/bes2020.127
Fecal Nucleic Acid Test as a Complementary Standard for Cured COVID-19 Patients
HAN Mei, ZOU Jing Bo, LI Huan, WEI Xiao Yu, YANG Song, ZHANG Hui Zheng, WANG Peng Sen, QIU Qian, WANG Le Le, CHEN Yao Kai, PAN Pin Liang
2020, 33(12): 935-939. doi: 10.3967/bes2020.128
Disinfection and Protective Measures for Makeshift Hospitals
WANG Jia Qi, LIU Xiao Li, DUAN Hong Yang, CHEN Xiao Min, QIAN Le, LYU Xi Fang, CHENG Yi Bin, LIANG Jian Sheng, YAO Xiao Yuan
2020, 33(12): 940-942. doi: 10.3967/bes2020.129
Detecting Environmental Contamination of Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Isolation Wards and Fever Clinics
CHEN Guo Min, JI Jia Jia, JIANG Shuai, XIAO Ya Qi, ZHANG Ren Li, HUANG Da Na, LIU Hui, YU Shu Yuan
2020, 33(12): 943-947. doi: 10.3967/bes2020.130
Emergency Department Experience in the Multi-dimensional Prevention and Control of Pneumonic Plague in Beijing
YANG Jun, MEI Xue, ZHAO Li Xin, LIU Ying Qing, WANG Shuo, GUO Shu Bin, HE Xin Hua
2020, 33(12): 948-952. doi: 10.3967/bes2020.131
Molecular Characterization of HIV-1-circulating Strains among Pre-Treatment Patients in Tibet
Dorjiwangmo, GAN Meng Ze, DONG Ao Bo, Baimayangjin, Tashibazong, LIU Lei, LIAO Ling Jie, RUAN Yu Hua, SHAO Yi Ming, FENG Yi, XING Hui
2020, 33(12): 953-958. doi: 10.3967/bes2020.132
Palmitoylation of AMPA Receptors is Involved in the Inhibition of Hippocampal Long-term Potentiation by Aluminum Exposure in Rats
SONG Jing, XIA Xin Yu, GAO Ting, YUAN Chun Man, LU Xiao Ting, WANG Lin Ping, ZHANG Hui Fang
2020, 33(12): 959-963. doi: 10.3967/bes2020.133