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Cover
2021, 34(3): 0-0.  
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Contents
Contents
2021, 34(3): 1-2.  
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Review
Japanese Encephalitis in China in the Period of 1950–2018: From Discovery to Control
CHEN Xiao Jing, WANG Huan Yu, LI Xiao Long, GAO Xiao Yan, LI Ming Hua, FU Shi Hong, HE Ying, LI Fan, YIN Qi Kai, XU Song Tao, WU Dan, LI Yi Xing, YIN Zun Dong, YANG Guang, LIANG Guo Dong
2021, 34(3): 175-183.   doi: 10.3967/bes2021.024
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Original Article
Combined Effect of Smoking and Obesity on Coronary Heart Disease Mortality in Male Veterans: A 30-year Cohort Study
SAI Xiao Yong, GAO Feng, ZHANG Wen Yu, GAO Meng, YOU Jing, SONG Yu Jian, LUO Ting Gang, SUN Yuan Yuan
2021, 34(3): 184-191.   doi: 10.3967/bes2021.012
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  Objective  Evidence is lacking regarding the combined effects of smoking and obesity on mortality from coronary heart disease in male veterans. This study aimed to explore the combined effect of smoking and obesity on coronary heart disease mortality in male veterans in China.  Methods  A cohort of 1,268 male veterans from 22 veteran centers in Xi’an (Shaanxi Province, China) were followed up once every 2 years from February 1, 1987 to October 30, 2016. The endpoint was death from any cause. The hazard ratio (HR) of each risk factor and the 95% confidence interval (CI) were calculated using a multivariate Cox proportional hazard model.  Results  The total follow-up was 24394.21 person-years; each subject was followed up for a mean duration of 19.24 years. By the end of the study, of the 1,268 veterans, 889 had died, 363 were alive, and 16 were lost to follow-up. Cox regression analysis results revealed that current smoking (HR: 1.552, 95% CI: 1.074–2.243), obesity (HR: 1.625, 95% CI: 1.024–2.581), and the combined effect of the two factors (HR: 2.828, 95% CI: 1.520–5.262) were associated with coronary heart disease mortality.  Conclusion  Our results suggest that obese veterans who smoke might be an important target population for coronary heart disease mortality control.
Aryl Hydrocarbon Receptor is Involved in the Proinflammatory Cytokine Response to Cadmium
KULAS Jelena, TUCOVIC Dina, ZELJKOVIC Milica, POPOVIC Dusanka, POPOV ALEKSANDROV Aleksandra, KATARANOVSKI Milena, MIRKOV Ivana
2021, 34(3): 192-202.   doi: 10.3967/bes2021.025
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  Objective  To investigate involvement of the aryl hydrocarbon receptor (AhR) in the immunomodulatory effects of cadmium (Cd).  Methods  The effect of Cd on AhR activation (CYP1A1 and CYP1B1 mRNA expression) was examined in lung leukocytes of Cd-exposed rats (5 and 50 mg/L, 30 d orally) and by in vitro leukocyte exposure. The involvement of AhR signaling in the effects of Cd on the interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF) lung leukocyte response was investigated in vitro using the receptor antagonist CH-223191.  Results  Cd increased CYP1B1 (in vivo and in vitro) and CYP1A1 (in vitro) mRNA, indicating AhR involvement in the action of Cd. In response to Cd, lung leukocytes increased IL-6 and decreased TNF at the gene expression and protein levels, but decreased IL-1β production due to reduced NLRP3. The AhR antagonist CH-223191 abrogated the observed effects of Cd on the cytokine response. The absence of AhR reactivity and cytokine response to Cd of leukocytes from the lungs of a rat strain that is less sensitive to Cd toxicity coincided with a high AhR repressor mRNA level.   Conclusion  AhR signaling is involved in the lung leukocyte proinflammatory cytokine response to Cd. The relevance of the AhR to the cytokine response to Cd provides new insight into the mechanisms of Cd immunotoxicity.
Mitochondrial Oxidative Stress Enhances Vasoconstriction by Altering Calcium Homeostasis in Cerebrovascular Smooth Muscle Cells under Simulated Microgravity
LIU Zi Fan, WANG Hai Ming, JIANG Min, WANG Lin, LIN Le Jian, ZHAO Yun Zhang, SHAO Jun Jie, ZHOU Jing Jing, XIE Man Jiang, LI Xin, ZHANG Ran
2021, 34(3): 203-212.   doi: 10.3967/bes2021.001
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  Objective  Exposure to microgravity results in postflight cardiovascular deconditioning in astronauts. Vascular oxidative stress injury and mitochondrial dysfunction have been reported during this process. To elucidate the mechanism for this condition, we investigated whether mitochondrial oxidative stress regulates calcium homeostasis and vasoconstriction in hindlimb unweighted (HU) rat cerebral arteries.   Methods  Three-week HU was used to simulate microgravity in rats. The contractile responses to vasoconstrictors, mitochondrial fission/fusion, Ca2+ distribution, inositol 1,4,5-trisphosphate receptor (IP3R) abundance, and the activities of voltage-gated K+ channels (KV) and Ca2+-activated K+ channels (BKCa) were examined in rat cerebral vascular smooth muscle cells (VSMCs).   Results  An increase of cytoplasmic Ca2+ and a decrease of mitochondrial/sarcoplasmic reticulum (SR) Ca2+ were observed in HU rat cerebral VSMCs. The abundance of fusion proteins (mitofusin 1/2 [MFN1/2]) and fission proteins (dynamin-related protein 1 [DRP1] and fission-mitochondrial 1 [FIS1]) was significantly downregulated and upregulated, respectively in HU rat cerebral VSMCs. The cerebrovascular contractile responses to vasoconstrictors were enhanced in HU rats compared to control rats, and IP3R protein/mRNA levels were significantly upregulated. The current densities and open probabilities of KV and BKCa decreased and increased, respectively. Treatment with the mitochondrial-targeted antioxidant mitoTEMPO attenuated mitochondrial fission by upregulating MFN1/2 and downregulating DRP1/FIS1. It also decreased IP3R expression levels and restored the activities of the KV and BKCa channels. MitoTEMPO restored the Ca2+ distribution in VSMCs and attenuated the enhanced vasoconstriction in HU rat cerebral arteries.   Conclusion  The present results suggest that mitochondrial oxidative stress enhances cerebral vasoconstriction by regulating calcium homeostasis during simulated microgravity.
MicroRNA-378a-3p Downregulation as a Novel Biomarker with Poor Clinical Outcomes in Cervical Cancer
ZHANG Liang, WU Zhen An
2021, 34(3): 213-221.   doi: 10.3967/bes2021.026
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  Objective  Cervical cancer (CC) is one of the most common malignant tumors in gynecology. This study aimed to investigate the prognostic significance of serum microRNA (miR)-378a-3p in CC and the effect of miR-378a-3p on tumor growth.  Methods  Real-time quantitative polymerase chain reaction analysis was used to measure the expression of miR-378a-3p in serum from patients with CC and healthy control subjects as well as from CC tissues and adjacent normal tissues. The association between serum miR-378a-3p levels and clinicopathological factors was analyzed. The correlation between miR-378a-3p levels and overall survival (OS) of CC patients was determined by Kaplan-Meier analysis. The CC cell proliferation and migration abilities after transfection of miR-378a-3p mimics were detected by Cell Counting Kit-8 and scratch wound healing assays, respectively. Tumor volume and weight in mice treated with miR-378a-3p were measured using a caliper and an electronic balance.  Results  MiR-378a-3p expression was downregulated in the serum and tissues of CC patients compared to that in healthy control subjects and normal tissues, respectively. Low expression of miR-378a-3p was positively correlated with large tumor size, advanced tumor stage, and lymph node metastasis. The OS of patients with low expression of miR-378a-3p was significantly lower than that of patients with high expression. Overexpression of miR-378a-3p suppressed the proliferation and migration of CC cells. In vivo studies indicated that overexpression of miR-378a-3p was associated with decreased tumor volume and weight in mice.  Conclusion  MiR-378a-3p downregulation is associated with the development and prognosis of CC, suggesting that it may be a potential biomarker for CC.
Letter to the Editor
Early Changes in Serologic Markers in Workers Exposed to Indium Compounds
LIU Nan, GUAN Yi, XUE Ling, LI Bin, YAO San Qiao
2021, 34(3): 222-226.   doi: 10.3967/bes2021.027
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A Nested-Polymerase Chain Reaction Assay to Identify and Genotype Brucella
TIAN Guo Zhong
2021, 34(3): 227-231.   doi: 10.3967/bes2021.028
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Seroprevalence of Brucellosis among Clinically Suspected Human Cases Presenting at Health Facilities in Namibia from 2012 to 2017
MADZINGIRA Oscar, FASINA Oludayo Folorunso, KALINDA Chester, VAN HEERDEN Henriette
2021, 34(3): 232-235.   doi: 10.3967/bes2021.029
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Decreased Plasma MANF Levels are Associated with Type 2 Diabetes
WANG Cong, PENG Jia Jia, MIAO He, LIU Dong Fang, ZHANG Li Li
2021, 34(3): 236-240.   doi: 10.3967/bes2021.030
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Ptpn22 Arg>Trp Polymorphism Improves Macrophage-Mediated Adipocyte Homeostasis
LI Mei Hang, SUN Chao, SUN Yuan Chao, NIU Yu Juan, WU Chuan Hong, POLYCHRONAKOS Constantin
2021, 34(3): 241-246.   doi: 10.3967/bes2021.031
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Investigating the Aggregation of Imported Cutaneous Leishmaniasis in Henan, Central China
ZHAO Yu Ling, LI Su Hua, ZHU Xin, ZHOU Rui Min, YANG Cheng Yun, LIU Ying, NIU Yuan Na, LU De Ling, ZHANG Hong Wei, ZHAO Dong Yang
2021, 34(3): 247-249.   doi: 10.3967/bes2021.032
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Prenatal Hypoxia Altered Angiotensin II-mediated Vasoconstrictions via PKC/ERK/ROCK Pathways and Potassium Channels in Rat Offsrping Middle Cerebral Artery
LI Da Wei, BO Le, TU Qing, ZHOU An Wen, SHI Lin Ling, YANG Xiao Jun, MAO Cai Ping
2021, 34(3): 250-255.   doi: 10.3967/bes2021.033
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The Serum Exosome Derived MicroRNA-135a, -193b, and-384 Were Potential Alzheimer's Disease Biomarkers
YANG Ting Ting, LIU Chen Geng, GAO Shi Chao, ZHANG Yi, WANG Pei Chang
2018, 31(2): 87-96.   doi: 10.3967/bes2018.011
[Abstract](3673) [FullText HTML](729) [PDF 11333KB](729)
Bone Injury and Fracture Healing Biology
Ahmad Oryan, Somayeh Monazzah, Amin Bigham-Sadegh
2015, 28(1): 57-71.   doi: 10.3967/bes2015.006
[Abstract](2912) [PDF 3875KB](915)
Stability of SARS Coronavirus in Human Specimens and Environment and Its Sensitivity to Heating and UV Irradiation
SHU-MING DUAN, Xin-sheng Zhao, RUI-FU WEN, JING-JING HUANG, GUO-HUA PI, SU-XIANG ZHANG, JUN HAN, SHENG-LI BI, LI RUAN, XIAO-PING DONG, SARS RESEARCH TEAM
2003, 16(3): 246-255.  
[Abstract](4792) [PDF 610KB](714)
Metabolomic Profiling Differences among Asthma, COPD, and Healthy Subjects: A LC-MS-based Metabolomic Analysis
LIANG Ying, GAI Xiao Yan, CHANG Chun, ZHANG Xu, WANG Juan, LI Ting Ting
2019, 32(9): 659-672.   doi: 10.3967/bes2019.085
[Abstract](2598) [FullText HTML](434) [PDF 2914KB](434)
Inactivation of Poliovirus by Ozone and the Impact of Ozone on the Viral Genome
JIANG Han Ji, CHEN Na, SHEN Zhi Qiang, YIN Jing, QIU Zhi Gang, MIAO Jing, YANG Zhong Wei, SHI Dan Yang, WANG Hua Ran, WANG Xin Wei, LI Jun Wen, YANG Dong, JIN Min
2019, 32(5): 324-333.   doi: 10.3967/bes2019.044
[Abstract](2455) [FullText HTML](370) [PDF 2666KB](370)
Resveratrol Induces Apoptosis and Autophagy in T-cell Acute Lymphoblastic Leukemia Cells by Inhibiting Akt/mTOR and Activating p38-MAPK
GE Jiao, LIU Yan, LI Qiang, GUO Xia, GU Ling, MA Zhi Gui, ZHU Yi Ping
2013, 26(11): 902-911.   doi: 10.3967/bes2013.019
[Abstract](2481) [PDF 12143KB](268)
Evaluating the Nutritional Status of Oncology Patientsand Its Association with Quality of Life
ZHANG Ya Hui, XIE Fang Yi, CHEN Ya Wen, WANG Hai Xia, TIAN Wen Xia, SUN Wen Guang, WU Jing
2018, 31(9): 637-644.   doi: 10.3967/bes2018.088
[Abstract](2948) [FullText HTML](406) [PDF 31943KB](406)
An Evaluation of the Investment for Child Development in China
ZHENG Xiao Ying, CHEN Chun Ming, HUANG Cheng Li, Han You Li, QIU Yue, ZHANG Qian Deng, CHEN He
2012, 25(4): 413-420.   doi: 10.3967/0895-3988.2012.04.006
[Abstract](2062) [PDF 183KB](221)
Burden of Cirrhosis and Other Chronic Liver Diseases Caused by Specific Etiologies in China, 1990−2016: Findings from the Global Burden of Disease Study 2016
LI Man, WANG Zhuo Qun, ZHANG Lu, ZHENG Hao, LIU Dian Wu, ZHOU Mai Geng
2020, 33(1): 1-10.   doi: 10.3967/bes2020.001
[Abstract](2599) [FullText HTML](384) [PDF 2552KB](384)
Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province, China
MAO Gen Xiang, LAN Xiao Guang, CAO Yong Bao, CHEN Zhuo Mei, HE Zhi Hua, LV Yuan Dong, WANG Ya Zhen, HU Xi Lian, WANG Guo Fu, YAN Jing
2012, 25(3): 317-324.   doi: 10.3967/0895-3988.2012.03.010
[Abstract](1653) [PDF 528KB](461)
Outline of the Report on Cardiovascular Disease in China, 2010
HU Sheng Shou, KONG Ling Zhi, GAO Run Lin, ZHU Man Lu, WANG Wen, WANG Yong Jun, WU Zhao Su, CHEN Wei Wei, LIU Ming Bo
2012, 25(3): 251-256.   doi: 10.3967/0895-3988.2012.03.001
[Abstract](3046) [PDF 2961KB](319)
Paraben Content in Adjacent Normal-malignant Breast Tissues from Women with Breast Cancer
Mohammad Mehdi Amin, Maryam Tabatabaeian, Afsane Chavoshani, Elham Amjadi, Majid Hashemi, Karim Ebrahimpour, Roya Klishadi, Sedigheh Khazaei, Marjan Mansourian
2019, 32(12): 893-904.   doi: 10.3967/bes2019.112
[Abstract](1971) [FullText HTML](433) [PDF 2461KB](433)
Analysis of Protoscoleces-specific Antigens from Echinococcus Granulosus with Proteomics Combined with Western Blot
LI Zong Ji, ZHAO Wei
2012, 25(6): 718-723.   doi: 10.3967/0895-3988.2012.06.015
[Abstract](1923) [PDF 279KB](211)
Protein Requirements in Healthy Adults:A Meta-analysis of Nitrogen Balance Studies
LI Min, SUN Feng, PIAO Jian Hua, YANG Xiao Guang
2014, 27(8): 606-613.   doi: 10.3967/bes2014.093
[Abstract](1253) [PDF 8784KB](352)
Mutual Impact of Diabetes Mellitus and Tuberculosis in China
CHENG Jun, ZHANG Hui, ZHAO Yan Lin, WANG Li Xia, CHEN Ming Ting
2017, 30(5): 384-389.   doi: 10.3967/bes2017.051
[Abstract](1749) [FullText HTML](380) [PDF 671KB](380)
A Study of the Technique of Western Blot for Diagnosis of Lyme Disease caused by Borrelia afzelii in China
LIU Zhi Yun, HAO Qin, HOU Xue Xia, JIANG Yi, GENG Zhen, WU Yi Mou, WAN Kang Lin
2013, 26(3): 190-200.   doi: 10.3967/0895-3988.2013.03.006
[Abstract](2388) [PDF 9794KB](337)
Exposure Effects of Terahertz Waves on Primary Neurons and Neuron-like Cells Under Nonthermal Conditions
TAN Sheng Zhi, TAN Peng Cheng, LUO Lan Qing, CHI Yun Liang, YANG Zi Long, ZHAO Xue Long, ZHAO Li, DONG Ji, ZHANG Jing, YAO Bin Wei, XU Xin Ping, TIAN Guang, CHEN Jian Kui, WANG Hui, PENG Rui Yun
2019, 32(10): 739-754.   doi: 10.3967/bes2019.094
[Abstract](1859) [FullText HTML](315) [PDF 3322KB](315)
Trends in Lipids Level and Dyslipidemia among Chinese Adults, 2002-2015
SONG Peng Kun, MAN Qing Qing, LI Hong, PANG Shao Jie, JIA Shan Shan, LI Yu Qian, HE Li, ZHAO Wen Hua, ZHANG Jian
2019, 32(8): 559-570.   doi: 10.3967/bes2019.074
[Abstract](2263) [FullText HTML](355) [PDF 3641KB](355)
Supplementation of Fermented Barley Extracts with Lactobacillus Plantarum dy-1 Inhibits Obesity via a UCP1-dependent Mechanism
XIAO Xiang, BAI Juan, LI Ming Song, ZHANG Jia Yan, SUN Xin Juan, DONG Ying
2019, 32(8): 578-591.   doi: 10.3967/bes2019.076
[Abstract](2856) [FullText HTML](339) [PDF 9101KB](339)
Viral and Bacterial Etiology of Acute Febrile Respiratory Syndrome among Patients in Qinghai, China
LIU Gao Shan, LI Hong, ZHAO Sheng Cang, LU Rou Jian, NIU Pei Hua, TAN Wen Jie
2019, 32(6): 438-445.   doi: 10.3967/bes2019.058
[Abstract](2473) [PDF 10063KB](306)

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Current Issue

Vol 34, No 3

(March, 2021)

ISSN 0895-3988

CN 11-2816/Q

  • 2019 Impact Factor 2.656

  • 2019 Journal Citation Reports