2023 Vol. 36, No. 6

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2023, 36(6)
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2023, 36(6): 1-2.
Obesity is positively Associated with Depression in Older Adults: Role of Systemic Inflammation
GUO Ye Xin, WANG An Qi, GAO Xin, NA Jun, ZHE Wei, ZENG Yi, ZHANG Jing Rui, JIANG Yuan Jing, YAN Fei, YUNUS Mukaram, WANG Hui, YIN Zhao Xue
2023, 36(6): 481-489. doi: 10.3967/bes2023.059
  Objective  We aimed to explore the association between obesity and depression and the role of systemic inflammation in older adults.  Methods  Adults ≥ 65 years old (n = 1,973) were interviewed at baseline in 2018 and 1,459 were followed up in 2021. General and abdominal obesity were assessed, and serum C-reactive protein (CRP) levels were measured at baseline. Depression status was assessed at baseline and at follow-up. Logistic regression was used to analyze the relationship between obesity and the incidence of depression and worsening of depressive symptoms, as well as the relationship between obesity and CRP levels. The associations of CRP levels with the geriatric depression scale, as well as with its three dimensions, were investigated using multiple linear regressions.  Results  General obesity was associated with worsening depression symptoms and incident depression, with an odds ratio (OR) [95% confidence interval (CI)] of 1.53 (1.13–2.12) and 1.80 (1.23–2.63), especially among old male subjects, with OR (95% CI) of 2.12 (1.25–3.58) and 2.24 (1.22–4.11), respectively; however, no significant relationship was observed between abdominal obesity and depression. In addition, general obesity was associated with high levels of CRP, with OR (95% CI) of 2.58 (1.75–3.81), especially in subjects free of depression at baseline, with OR (95% CI) of 3.15 (1.97–5.04), and CRP levels were positively correlated with a score of specific dimension (life satisfaction) of depression, P < 0.05.  Conclusion  General obesity, rather than abdominal obesity, was associated with worsening depressive symptoms and incident depression, which can be partly explained by the systemic inflammatory response, and the impact of obesity on depression should be taken more seriously in the older male population.
Benchmark Dose Assessment for Coke Oven Emissions-Induced Mitochondrial DNA Copy Number Damage Effects
YAN Zhao Fan, GU Zhi Guang, FAN Ya Hui, LI Xin Ling, NIU Ze Ming, DUAN Xiao Ran, Mallah Ali Manthar, ZHANG Qiao, YANG Yong Li, YAO Wu, WANG Wei
2023, 36(6): 490-500. doi: 10.3967/bes2023.060
  Objective  The study aimed to estimate the benchmark dose (BMD) of coke oven emissions (COEs) exposure based on mitochondrial damage with the mitochondrial DNA copy number (mtDNAcn) as a biomarker.  Methods  A total of 782 subjects were recruited, including 238 controls and 544 exposed workers. The mtDNAcn of peripheral leukocytes was detected through the real-time fluorescence-based quantitative polymerase chain reaction. Three BMD approaches were used to calculate the BMD of COEs exposure based on the mitochondrial damage and its 95% confidence lower limit (BMDL).  Results  The mtDNAcn of the exposure group was lower than that of the control group (0.60 ± 0.29 vs. 1.03 ± 0.31; P < 0.001). A dose–response relationship was shown between the mtDNAcn damage and COEs. Using the Benchmark Dose Software, the occupational exposure limits (OELs) for COEs exposure in males was 0.00190 mg/m3. The OELs for COEs exposure using the BBMD were 0.00170 mg/m3 for the total population, 0.00158 mg/m3 for males, and 0.00174 mg/m3 for females. In possible risk obtained from animal studies (PROAST), the OELs of the total population, males, and females were 0.00184, 0.00178, and 0.00192 mg/m3, respectively.  Conclusion  Based on our conservative estimate, the BMDL of mitochondrial damage caused by COEs is 0.002 mg/m3. This value will provide a benchmark for determining possible OELs.
Cost-Effectiveness Analysis of Combined Chemotherapy Regimen Containing Bedaquiline in the Treatment of Multidrug-Resistant Tuberculosis in China
XU Cai Hong, QIU Ying Peng, HE Zi Long, HU Dong Mei, YUE Xiao, CHEN Zhong Dan, XU Yuan Yuan, ZHAO Yan Lin
2023, 36(6): 501-509. doi: 10.3967/bes2023.061
  Objective   This study aims to estimate the cost-effectiveness of the combined chemotherapy regimen containing Bedaquiline (BR) and the conventional treatment regimen (CR, not containing Bedaquiline) for the treatment of adults with multidrug-resistant tuberculosis (MDR-TB) in China.   Methods   A combination of a decision tree and a Markov model was developed to estimate the cost and effects of MDR patients in BR and CR within ten years. The model parameter data were synthesized from the literature, the national TB surveillance information system, and consultation with experts. The incremental cost-effectiveness ratio (ICER) of BR vs. CR was determined.   Results   BR (vs. CR) had a higher sputum culture conversion rate and cure rate and prevented many premature deaths (decreased by 12.8%), thereby obtaining more quality-adjusted life years (QALYs) (increased by 2.31 years). The per capita cost in BR was as high as 138,000 yuan, roughly double that of CR. The ICER for BR was 33,700 yuan/QALY, which was lower than China’s 1× per capita Gross Domestic Product (GDP) in 2020 (72,400 yuan).   Conclusion   BR is shown to be cost effective. When the unit price of Bedaquiline reaches or falls below 57.21 yuan per unit, BR is expected to be the dominant strategy in China over CR.
Diagnostic Efficacy of 18F-FDG PET/CT in Detecting Bone Marrow Infiltration in Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma
GUO Bo, QIN Ran, GU Zhen Yang, LI Yan Fen, GAO Lei, HUANG Wen Rong
2023, 36(6): 510-516. doi: 10.3967/bes2023.062
  Objective  Diffuse large B-cell lymphoma (DLBCL) is often associated with bone marrow infiltration, and 2-deoxy-2-(18F) fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has potential diagnostic significance for bone marrow infiltration in DLBCL.  Methods  A total of 102 patients diagnosed with DLBCL between September 2019 and August 2022 were included. Bone marrow biopsy and 18F-FDG PET/CT examinations were performed at the time of initial diagnosis. Kappa tests were used to evaluate the agreement of 18F-FDG PET/CT with the gold standard, and the imaging features of DLBCL bone marrow infiltration on PET/CT were described.  Results  The total detection rate of bone marrow infiltration was not significantly different between PET/CT and primary bone marrow biopsy (P = 0.302) or between the two bone marrow biopsies (P = 0.826). The sensitivity, specificity, and Youden index of PET/CT for the diagnosis of DLBCL bone marrow infiltration were 0.923 (95% CI, 0.759−0.979), 0.934 (95% CI, 0.855−0.972), and 0.857, respectively.  Conclusion  18F-FDG PET/CT has a comparable efficiency in the diagnosis of DLBCL bone marrow infiltration. PET/CT-guided bone marrow biopsy can reduce the misdiagnosis of DLBCL bone marrow infiltration.
Effect of Home Blood Pressure Telemonitoring Plus Additional Support on Blood Pressure Control: A Randomized Clinical Trial
MENG Wen Wen, BAI Yong Yi, YAN Li, ZHENG Wei, ZENG Qiang, ZHENG Yan Song, ZHA Lin, PI Hong Ying, SAI Xiao Yong
2023, 36(6): 517-526. doi: 10.3967/bes2023.063
  Objective  Current clinical evidence on the effects of home blood pressure telemonitoring (HBPT) on improving blood pressure control comes entirely from developed countries. Thus, we performed this randomized controlled trial to evaluate whether HBPT plus support (patient education and clinician remote hypertension management) improves blood pressure control more than usual care (UC) in the Chinese population.  Methods  This single-center, randomized controlled study was conducted in Beijing, China. Patients aged 30–75 years were eligible for enrolment if they had blood pressure [systolic (SBP) ≥ 140 mmHg and/or diastolic (DBP) ≥ 90 mmHg; or SBP ≥ 130 mmHg and/or DBP ≥ 80 mmHg with diabetes]. We recruited 190 patients randomized to either the HBPT or the UC groups for 12 weeks. The primary endpoints were blood pressure reduction and the proportion of patients achieving the target blood pressure.  Results  Totally, 172 patients completed the study, the HBPT plus support group (n = 84), and the UC group (n = 88). Patients in the plus support group showed a greater reduction in mean ambulatory blood pressure than those in the UC group. The plus support group had a significantly higher proportion of patients who achieved the target blood pressure and maintained a dipper blood pressure pattern at the 12th week of follow-up. Additionally, the patients in the plus support group showed lower blood pressure variability and higher drug adherence than those in the UC group.  Conclusion  HBPT plus additional support results in greater blood pressure reduction, better blood pressure control, a higher proportion of dipper blood pressure patterns, lower blood pressure variability, and higher drug adherence than UC. The development of telemedicine may be the cornerstone of hypertension management in primary care.
Impact of Smoke-Free Legislation on Acute Myocardial Infarction and Subtypes of Stroke Incidence in Shenzhen, China, 2012–2016: An Interrupted Time Series Analysis
SHI Yu Lin, XIONG Jing Fan, LIU Li Qun, ZHAO Zhi Guang, WAN Xia, PENG Ji
2023, 36(6): 527-536. doi: 10.3967/bes2023.064
  Objective  This study assesses the impact of smoke-free legislation on the incidence rate for acute myocardial infarction (AMI) and stroke in Shenzhen.   Methods  Data on ischemic (n = 72,945) and hemorrhagic (n = 18,659) stroke and AMI (n = 17,431) incidence covering about 12 million people in Shenzhen from 2012 to 2016 were used. Immediate and gradual changes in incidence rates were analyzed using segmented Poisson regression.   Results  Following the smoke-free legislation, a 9% (95% CI: 3%–15%) immediate reduction was observed in AMI incidence, especially in men (8%, 95% CI: 1%–14%) and in those aged 65 years and older (17%, 95% CI: 9%–25%). The gradual annual benefits were observed only in hemorrhagic and ischemic stroke incidence, with a 7% (95% CI: 2%–11%) and 6% (95% CI: 4%–8%) decrease per year, respectively. This health effect extended gradually to the 50–64 age group. In addition, neither the immediate nor gradual decrease in stroke and AMI incidence rates did not show statistical significance among the 35–49 age group (P > 0.05).   Conclusion  Smoke-free legislation was enforced well in Shenzhen, which would generate good experiences for other cities to enact and enforce smoke-free laws. This study also provided more evidence of the health benefits of smoke-free laws on stroke and AMI.
Changes in Urinary Metabolomics of Female Kashin-Beck Disease Patients in Qinghai-Tibet Plateau, China
LI Qiang, ZHOU Xin, XUE Hong Mei, WANG Jian Ling, LI Ji Quan, ZHAO Yan Mei, CHAO Jie, CHEN Yang Yang, XU Li Qing, ZHAO Zhi Jun, WANG Li Hua
2023, 36(6): 537-541. doi: 10.3967/bes2023.065
Differences in Pandemic-Related Factors Associated with Alcohol and Substance Use among Korean Adolescents: Nationwide Representative Study
Hyunju Yon, Sangil Park, Jung U Shin, Ai Koyanagi, Louis Jacob, Lee Smith, Chanyang Min, Jinseok Lee, Rosie Kwon, Guillaume Fond, Laurent Boyer, Sunyoung Kim, Namwoo Kim, Sang Youl Rhee, Jae Il Shin, Dong Keon Yon, Ho Geol Woo
2023, 36(6): 542-548. doi: 10.3967/bes2023.066
Improved Specificity for Breast Cancer Screening Using an Oncogenic (miRNA-21) and a Gene Suppressor (miRNA-195) miRNA in the Serum for a Point of Care (POC) Screening Solution
Krishnamoorthy Kokilavani, Ancy Terryna Chanayiltharayil John, Bindu Salim, Madhulika Vijayakumar, Sankar Ganesh Jeyaraj
2023, 36(6): 549-552. doi: 10.3967/bes2023.067
Trends of Oral Cancer Mortality in China from 1990 to 2019 and a 15-Year Predictive Analysis Based on a Bayesian Age-Period-Cohort Model
GU Jian Chang, SONG Ji Wu, LIU Yun, WANG Xiao Lan, XU Shuang Shuang, ZHANG Liang Liang, LIU Yun Xia, DING Gang
2023, 36(6): 553-556. doi: 10.3967/bes2023.068
Contribution of Ambient Air Pollution on Risk Assessment of Type 2 Diabetes Mellitus via Explainable Machine Learning
DING Zhong Ao, ZHANG Li Ying, LI Rui Ying, NIU Miao Miao, ZHAO Bo, DONG Xiao Kang, LIU Xiao Tian, HOU Jian, MAO Zhen Xing, WANG Chong Jian
2023, 36(6): 557-560. doi: 10.3967/bes2023.069
A Rapid and Accurate CRISPR/Cas12b-Mediated Genotyping Assay for the Methylenetetrahydrofolate Reductase Gene Polymorphism C677T
SI Xin Xin, ZHANG Quan, LUO Zhi Dan, ZHANG Zhen Yu, WANG Yan, SHAO Li Pei
2023, 36(6): 561-565. doi: 10.3967/bes2023.070
The First China Sports and Health Conference was Held in Beijing
2023, 36(6): 566-566. doi: 10.3967/bes2023.081
One Health for Rabies Elimination: China Rabies Annual Conference in 2023
2023, 36(6): 567-567. doi: 10.3967/bes2023.082