ZHANG Yong Peng; PENG Xiao Yan; LI Zhi Hua; CHEN Feng Hua

doi:10.3967/0895-3988.2012.03.009

Hyperglycemic Effects of a Periocular Dexamethasone Injection in Diabetic Patients after Vitreoretinal Surgery

ZHANG Yong Peng, PENG Xiao Yan, LI Zhi Hua, CHEN Feng Hua

文章导航 > Biomedical and Environmental Sciences > 2012 > 25(3): 311-316

ZHANG Yong Peng, PENG Xiao Yan, LI Zhi Hua, CHEN Feng Hua. Hyperglycemic Effects of a Periocular Dexamethasone Injection in Diabetic Patients after Vitreoretinal Surgery[J]. Biomedical and Environmental Sciences, 2012, 25(3): 311-316. doi: 10.3967/0895-3988.2012.03.009

Citation:

ZHANG Yong Peng, PENG Xiao Yan, LI Zhi Hua, CHEN Feng Hua. Hyperglycemic Effects of a Periocular Dexamethasone Injection in Diabetic Patients after Vitreoretinal Surgery[J]. Biomedical and Environmental Sciences, 2012, 25(3): 311-316. doi: 10.3967/0895-3988.2012.03.009

doi: 10.3967/0895-3988.2012.03.009

Hyperglycemic Effects of a Periocular Dexamethasone Injection in Diabetic Patients after Vitreoretinal Surgery

Beijing Ophthalmology and Visual Science Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital,Capital Medical University, Beijing 100730, China

摘要: Objective To examine the hyperglycemic effects of periocular dexamethasone injection in type 2 diabetic patients after vitreoretinal surgery (VRS).Methods This was a retrospective non-randomized controlled trial.Twenty consecutive hospitalized patients with type 2 diabetes and ocular inflammatory reaction after VRS were enrolled in this study.Ten patients received 2.5 mg dexamethasone and 10 patients received 5 mg dexamethasone.Fourteen consecutive type 2 diabetic patients without ocular inflammatory reaction after VRS were used as control group.We measured fasting blood glucose (FBG) and at 2 h after each meal (post prandial glucose,PBG; 09:00,13:00,and 19:00 h) after periocular dexamethasone injection.Differences among three groups were determined by q tests.Results The PBG levels in both dexamethasone-treated groups started to increase within 5 h after injection (i.e.,PBG at 13:00 h),and were significantly increased at 19:00 h after injection (P＜0.05).BG levels were almost 2-fold higher than at baseline and compared with the control group.The BG values declined gradually by 24 h to 48 h after injection.There were no differences in BG levels between the two dexamethasone-treated groups (P＞0.05),except for PBG at 19:00 h on day 2 after injection (P＜0.05).Conclusion Periocular dexamethasone injection can cause transient hyperglycemia in diabetic patients after VRS.BG monitoring should be performed following such injection.
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Abstract: Objective To examine the hyperglycemic effects of periocular dexamethasone injection in type 2 diabetic patients after vitreoretinal surgery (VRS).Methods This was a retrospective non-randomized controlled trial.Twenty consecutive hospitalized patients with type 2 diabetes and ocular inflammatory reaction after VRS were enrolled in this study.Ten patients received 2.5 mg dexamethasone and 10 patients received 5 mg dexamethasone.Fourteen consecutive type 2 diabetic patients without ocular inflammatory reaction after VRS were used as control group.We measured fasting blood glucose (FBG) and at 2 h after each meal (post prandial glucose,PBG; 09:00,13:00,and 19:00 h) after periocular dexamethasone injection.Differences among three groups were determined by q tests.Results The PBG levels in both dexamethasone-treated groups started to increase within 5 h after injection (i.e.,PBG at 13:00 h),and were significantly increased at 19:00 h after injection (P＜0.05).BG levels were almost 2-fold higher than at baseline and compared with the control group.The BG values declined gradually by 24 h to 48 h after injection.There were no differences in BG levels between the two dexamethasone-treated groups (P＞0.05),except for PBG at 19:00 h on day 2 after injection (P＜0.05).Conclusion Periocular dexamethasone injection can cause transient hyperglycemia in diabetic patients after VRS.BG monitoring should be performed following such injection.
- Dexamethasone /
- Periocular injection /
- Vitreoretinal surgery /
- Diabetes mellitus /
- Blood glucose

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Hyperglycemic Effects of a Periocular Dexamethasone Injection in Diabetic Patients after Vitreoretinal Surgery

doi: 10.3967/0895-3988.2012.03.009

刊出日期: 2012-06-20

关键词:

Dexamethasone /

Periocular injection /

Vitreoretinal surgery /

Diabetes mellitus /

Blood glucose

摘要: Objective To examine the hyperglycemic effects of periocular dexamethasone injection in type 2 diabetic patients after vitreoretinal surgery (VRS).Methods This was a retrospective non-randomized controlled trial.Twenty consecutive hospitalized patients with type 2 diabetes and ocular inflammatory reaction after VRS were enrolled in this study.Ten patients received 2.5 mg dexamethasone and 10 patients received 5 mg dexamethasone.Fourteen consecutive type 2 diabetic patients without ocular inflammatory reaction after VRS were used as control group.We measured fasting blood glucose (FBG) and at 2 h after each meal (post prandial glucose,PBG; 09:00,13:00,and 19:00 h) after periocular dexamethasone injection.Differences among three groups were determined by q tests.Results The PBG levels in both dexamethasone-treated groups started to increase within 5 h after injection (i.e.,PBG at 13:00 h),and were significantly increased at 19:00 h after injection (P＜0.05).BG levels were almost 2-fold higher than at baseline and compared with the control group.The BG values declined gradually by 24 h to 48 h after injection.There were no differences in BG levels between the two dexamethasone-treated groups (P＞0.05),except for PBG at 19:00 h on day 2 after injection (P＜0.05).Conclusion Periocular dexamethasone injection can cause transient hyperglycemia in diabetic patients after VRS.BG monitoring should be performed following such injection.

English Abstract

Hyperglycemic Effects of a Periocular Dexamethasone Injection in Diabetic Patients after Vitreoretinal Surgery

Beijing Ophthalmology and Visual Science Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital,Capital Medical University, Beijing 100730, China

Publish Date: 2012-06-20

Keywords:

Abstract: Objective To examine the hyperglycemic effects of periocular dexamethasone injection in type 2 diabetic patients after vitreoretinal surgery (VRS).Methods This was a retrospective non-randomized controlled trial.Twenty consecutive hospitalized patients with type 2 diabetes and ocular inflammatory reaction after VRS were enrolled in this study.Ten patients received 2.5 mg dexamethasone and 10 patients received 5 mg dexamethasone.Fourteen consecutive type 2 diabetic patients without ocular inflammatory reaction after VRS were used as control group.We measured fasting blood glucose (FBG) and at 2 h after each meal (post prandial glucose,PBG; 09:00,13:00,and 19:00 h) after periocular dexamethasone injection.Differences among three groups were determined by q tests.Results The PBG levels in both dexamethasone-treated groups started to increase within 5 h after injection (i.e.,PBG at 13:00 h),and were significantly increased at 19:00 h after injection (P＜0.05).BG levels were almost 2-fold higher than at baseline and compared with the control group.The BG values declined gradually by 24 h to 48 h after injection.There were no differences in BG levels between the two dexamethasone-treated groups (P＞0.05),except for PBG at 19:00 h on day 2 after injection (P＜0.05).Conclusion Periocular dexamethasone injection can cause transient hyperglycemia in diabetic patients after VRS.BG monitoring should be performed following such injection.

Citation: