WANG Sheng Li; YU Lu Gang; LIU Ren Ping; ZHU Wan Zhan; GAO Wei Min; XUE Li Ping; JIANG Xu

doi:10.3967/bes2014.131

Gene-Gene Interaction of GJB2, SOD2, and CAT on Occupational Noise-induced Hearing Loss in Chinese Han Population

WANG Sheng Li, YU Lu Gang, LIU Ren Ping, ZHU Wan Zhan, GAO Wei Min, XUE Li Ping, JIANG Xu

文章导航 > Biomedical and Environmental Sciences > 2014 > 27(12): 965-968

WANG Sheng Li, YU Lu Gang, LIU Ren Ping, ZHU Wan Zhan, GAO Wei Min, XUE Li Ping, JIANG Xu. Gene-Gene Interaction of GJB2, SOD2, and CAT on Occupational Noise-induced Hearing Loss in Chinese Han Population[J]. Biomedical and Environmental Sciences, 2014, 27(12): 965-968. doi: 10.3967/bes2014.131

Citation:

WANG Sheng Li, YU Lu Gang, LIU Ren Ping, ZHU Wan Zhan, GAO Wei Min, XUE Li Ping, JIANG Xu. Gene-Gene Interaction of GJB2, SOD2, and CAT on Occupational Noise-induced Hearing Loss in Chinese Han Population[J]. Biomedical and Environmental Sciences, 2014, 27(12): 965-968. doi: 10.3967/bes2014.131

doi: 10.3967/bes2014.131

Gene-Gene Interaction of GJB2, SOD2, and CAT on Occupational Noise-induced Hearing Loss in Chinese Han Population

Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123,Jiangsu, China; Suzhou Industrial Park Centers for Disease Control and Prevention(Institute of Health Inspection and Supervision), Suzhou 215021, Jiangsu, China
Suzhou Industrial Park Centers for Disease Control and Prevention(Institute of Health Inspection and Supervision), Suzhou 215021, Jiangsu, China

摘要: The effects of genetic factors on the noise-induced hearing loss (NIHL) are still unclear.In the present study,eight single-nucleotide polymorphisms (SNPs) included rs1227049 and rs3802711 (CDH23),rs169S (GSTP1),rs137852540 (GJB2),rs2289274 (PMCA2),rs4880 (SOD2),rs7943316,and rs769214 within CAT that might associated with NIHL were further validated in Chinese workers.The results showed that the carriers of the T allele (AT+TT) of rs7943316 and A allele (GA+AA) of rs769214,were significantly associated with an increased risk of NIHL compared to those with AA genotype (P＜0.05) and GG genotype (P＜0.05).
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- Chinese Han Population /
- genetic factors /
- Chinese workers /
- hearing loss

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Gene-Gene Interaction of GJB2, SOD2, and CAT on Occupational Noise-induced Hearing Loss in Chinese Han Population

doi: 10.3967/bes2014.131

刊出日期: 2014-12-20

关键词:

Chinese Han Population /

genetic factors /

Chinese workers /

hearing loss

摘要: The effects of genetic factors on the noise-induced hearing loss (NIHL) are still unclear.In the present study,eight single-nucleotide polymorphisms (SNPs) included rs1227049 and rs3802711 (CDH23),rs169S (GSTP1),rs137852540 (GJB2),rs2289274 (PMCA2),rs4880 (SOD2),rs7943316,and rs769214 within CAT that might associated with NIHL were further validated in Chinese workers.The results showed that the carriers of the T allele (AT+TT) of rs7943316 and A allele (GA+AA) of rs769214,were significantly associated with an increased risk of NIHL compared to those with AA genotype (P＜0.05) and GG genotype (P＜0.05).

English Abstract

Citation:

WANG Sheng Li, YU Lu Gang, LIU Ren Ping, ZHU Wan Zhan, GAO Wei Min, XUE Li Ping, JIANG Xu. Gene-Gene Interaction of GJB2, SOD2, and CAT on Occupational Noise-induced Hearing Loss in Chinese Han Population[J]. Biomedical and Environmental Sciences, 2014, 27(12): 965-968. doi: 10.3967/bes2014.131