LI Ying; HUANG Ke; JI Pei Li; SONG Lei; LIU Hong Tu

doi:10.3967/bes2016.098

Cervical Infection of Oncogenic Human Papillomavirus (HPV) Types in Beijing, China

LI Ying, HUANG Ke, JI Pei Li, SONG Lei, LIU Hong Tu

文章导航 > Biomedical and Environmental Sciences > 2016 > 29(10): 734-741

LI Ying, HUANG Ke, JI Pei Li, SONG Lei, LIU Hong Tu. Cervical Infection of Oncogenic Human Papillomavirus (HPV) Types in Beijing, China[J]. Biomedical and Environmental Sciences, 2016, 29(10): 734-741. doi: 10.3967/bes2016.098

Citation:

LI Ying, HUANG Ke, JI Pei Li, SONG Lei, LIU Hong Tu. Cervical Infection of Oncogenic Human Papillomavirus (HPV) Types in Beijing, China[J]. Biomedical and Environmental Sciences, 2016, 29(10): 734-741. doi: 10.3967/bes2016.098

doi: 10.3967/bes2016.098

基金项目: National Science and Technology Major Project funded by the Chinese government [2013ZX10004-101]。

Cervical Infection of Oncogenic Human Papillomavirus (HPV) Types in Beijing, China

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Department of 0bstetrics and Gynaecology, Chinese PLA General Hospital, Beijing 100853, China

Funds: National Science and Technology Major Project funded by the Chinese government [2013ZX10004-101]。

摘要: ObjectiveThis study was designed to determine the prevalence of oncogenic human papillomavirus (HPV) in cervical infections in Beijing, China, and to investigate the odds ratio (OR) of HPV single and multiple infections in abnormal cytology. MethodsA total of 19,018 specimens from outpatients in thedepartment ofobstetric andgynecology were collected. They were detected usinghigh-risk HPV genotyping real-time polymerase chain reaction (PCR) kit and analyzed by ThinPrep cytology test for cervical pathological diagnosis. HPV prevalence, age-specific prevalence, andOR of each type of HPV in abnormal cytology were analyzed. ResultsOverall, 19.1% (3,623/19,018) of the individuals were positive for HPV infection, 14.9%(2,833/19,018) were positive for a single HPV type, and 4.2% (790/19,018) were positive for multiple types. Among the 3,623 HPV-positive individuals, the most predominant HPV types were HPV52 (4.4%, 834/19,018), HPV16 (3.7%, 710/19,018), and HPV58 (3.4%, 644/19,018). TheOR of multiple infections and single infection differed significantly among disease severities. TheOR of dual infection was higher than that of each of the two single infection types, respectively. ConclusionHPV prevalence in the outpatients was 19.1%, and the most predominant HPV types in the study were HPV52, HPV16, and HPV58. Women with multiple infectionswere more likely to have abnormal cytology.
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Abstract: ObjectiveThis study was designed to determine the prevalence of oncogenic human papillomavirus (HPV) in cervical infections in Beijing, China, and to investigate the odds ratio (OR) of HPV single and multiple infections in abnormal cytology. MethodsA total of 19,018 specimens from outpatients in thedepartment ofobstetric andgynecology were collected. They were detected usinghigh-risk HPV genotyping real-time polymerase chain reaction (PCR) kit and analyzed by ThinPrep cytology test for cervical pathological diagnosis. HPV prevalence, age-specific prevalence, andOR of each type of HPV in abnormal cytology were analyzed. ResultsOverall, 19.1% (3,623/19,018) of the individuals were positive for HPV infection, 14.9%(2,833/19,018) were positive for a single HPV type, and 4.2% (790/19,018) were positive for multiple types. Among the 3,623 HPV-positive individuals, the most predominant HPV types were HPV52 (4.4%, 834/19,018), HPV16 (3.7%, 710/19,018), and HPV58 (3.4%, 644/19,018). TheOR of multiple infections and single infection differed significantly among disease severities. TheOR of dual infection was higher than that of each of the two single infection types, respectively. ConclusionHPV prevalence in the outpatients was 19.1%, and the most predominant HPV types in the study were HPV52, HPV16, and HPV58. Women with multiple infectionswere more likely to have abnormal cytology.
- Cervical cancer /
- HPV /
- TCT /
- LSIL /
- HSIL /
- Odds ratios

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Cervical Infection of Oncogenic Human Papillomavirus (HPV) Types in Beijing, China

doi: 10.3967/bes2016.098

基金项目: National Science and Technology Major Project funded by the Chinese government [2013ZX10004-101]。

刊出日期: 2016-10-20

关键词:

Cervical cancer /

HPV /

TCT /

LSIL /

HSIL /

Odds ratios

摘要: ObjectiveThis study was designed to determine the prevalence of oncogenic human papillomavirus (HPV) in cervical infections in Beijing, China, and to investigate the odds ratio (OR) of HPV single and multiple infections in abnormal cytology. MethodsA total of 19,018 specimens from outpatients in thedepartment ofobstetric andgynecology were collected. They were detected usinghigh-risk HPV genotyping real-time polymerase chain reaction (PCR) kit and analyzed by ThinPrep cytology test for cervical pathological diagnosis. HPV prevalence, age-specific prevalence, andOR of each type of HPV in abnormal cytology were analyzed. ResultsOverall, 19.1% (3,623/19,018) of the individuals were positive for HPV infection, 14.9%(2,833/19,018) were positive for a single HPV type, and 4.2% (790/19,018) were positive for multiple types. Among the 3,623 HPV-positive individuals, the most predominant HPV types were HPV52 (4.4%, 834/19,018), HPV16 (3.7%, 710/19,018), and HPV58 (3.4%, 644/19,018). TheOR of multiple infections and single infection differed significantly among disease severities. TheOR of dual infection was higher than that of each of the two single infection types, respectively. ConclusionHPV prevalence in the outpatients was 19.1%, and the most predominant HPV types in the study were HPV52, HPV16, and HPV58. Women with multiple infectionswere more likely to have abnormal cytology.

English Abstract

Cervical Infection of Oncogenic Human Papillomavirus (HPV) Types in Beijing, China

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China

Department of 0bstetrics and Gynaecology, Chinese PLA General Hospital, Beijing 100853, China

Funds: National Science and Technology Major Project funded by the Chinese government [2013ZX10004-101]。

Publish Date: 2016-10-20

Keywords:

Cervical cancer /
HPV /
TCT /
LSIL /
HSIL /
Odds ratios

Abstract: ObjectiveThis study was designed to determine the prevalence of oncogenic human papillomavirus (HPV) in cervical infections in Beijing, China, and to investigate the odds ratio (OR) of HPV single and multiple infections in abnormal cytology. MethodsA total of 19,018 specimens from outpatients in thedepartment ofobstetric andgynecology were collected. They were detected usinghigh-risk HPV genotyping real-time polymerase chain reaction (PCR) kit and analyzed by ThinPrep cytology test for cervical pathological diagnosis. HPV prevalence, age-specific prevalence, andOR of each type of HPV in abnormal cytology were analyzed. ResultsOverall, 19.1% (3,623/19,018) of the individuals were positive for HPV infection, 14.9%(2,833/19,018) were positive for a single HPV type, and 4.2% (790/19,018) were positive for multiple types. Among the 3,623 HPV-positive individuals, the most predominant HPV types were HPV52 (4.4%, 834/19,018), HPV16 (3.7%, 710/19,018), and HPV58 (3.4%, 644/19,018). TheOR of multiple infections and single infection differed significantly among disease severities. TheOR of dual infection was higher than that of each of the two single infection types, respectively. ConclusionHPV prevalence in the outpatients was 19.1%, and the most predominant HPV types in the study were HPV52, HPV16, and HPV58. Women with multiple infectionswere more likely to have abnormal cytology.

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doi: 10.3967/bes2016.098

Cervical Infection of Oncogenic Human Papillomavirus (HPV) Types in Beijing, China

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Cervical Infection of Oncogenic Human Papillomavirus (HPV) Types in Beijing, China

doi: 10.3967/bes2016.098

English Abstract

Cervical Infection of Oncogenic Human Papillomavirus (HPV) Types in Beijing, China

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China Department of 0bstetrics and Gynaecology, Chinese PLA General Hospital, Beijing 100853, China

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National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China

Department of 0bstetrics and Gynaecology, Chinese PLA General Hospital, Beijing 100853, China