Effects of Soybean Fibers on Blood Sugar, Lipid Levels and Hepatic_Nephritic Histomorphology in Mice With Diabetes Mellitus

XU HONG; TAN SHU_MEI; LI SHU_QING

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Volume 14 Issue 3

Sep. 2001

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Article Navigation > Biomedical and Environmental Sciences > 2001 > 14(3): 256-261

XU HONG, TAN SHU_MEI, LI SHU_QING. Effects of Soybean Fibers on Blood Sugar, Lipid Levels and Hepatic_Nephritic Histomorphology in Mice With Diabetes Mellitus[J]. Biomedical and Environmental Sciences, 2001, 14(3): 256-261.

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XU HONG, TAN SHU_MEI, LI SHU_QING. Effects of Soybean Fibers on Blood Sugar, Lipid Levels and Hepatic_Nephritic Histomorphology in Mice With Diabetes Mellitus[J]. Biomedical and Environmental Sciences, 2001, 14(3): 256-261.

Effects of Soybean Fibers on Blood Sugar, Lipid Levels and Hepatic_Nephritic Histomorphology in Mice With Diabetes Mellitus

Jinan Military General Hospital,

Abstract

Objective To study the influence of soybean fibers on blood sugar, blood_lipid metabolism, and histomorphology in mice models with diabetes mellitus (DM). Method After normal mice and mice with Streptozocin (STZ)_induced DM were fed with forage containing a certain amount of soybean fiber (SF) for 5 weeks, blood sugar and blood lipid were determined, and morphological changes of hepatic and nephritic tissues were observated. Result The results of 5_week experiment had shown: 1. In normal mice fed with SF, the blood sugar level was decreased (P<0.05). There were no obvious changes in serum total cholesterol (TC) and the triglyceride (TG). The high_density_lipoprotein cholesterol (HDL_C) level was increased significantly (P<0.05); 2. Among DM mice, blood sugar was decreased considerably (P<0.001), TC and TG also decreased noticeably (P<0.05), HDL_C increased clearly (P<0.05); 3. SF has a protective role to the liver and kidney of DM mice. Conclusion It is suggested that SF has the function of decreasing blood sugar, blood_lipid and improving their metabolism, and of protecting liver and kidney of DM mice.
- Blood Sugar,
- blood sugar,
- morphological changes,
- diabetes mellitus,
- protecting liver,
- blood lipid
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Effects of Soybean Fibers on Blood Sugar, Lipid Levels and Hepatic_Nephritic Histomorphology in Mice With Diabetes Mellitus

Jinan Military General Hospital,

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Abstract: Objective To study the influence of soybean fibers on blood sugar, blood_lipid metabolism, and histomorphology in mice models with diabetes mellitus (DM). Method After normal mice and mice with Streptozocin (STZ)_induced DM were fed with forage containing a certain amount of soybean fiber (SF) for 5 weeks, blood sugar and blood lipid were determined, and morphological changes of hepatic and nephritic tissues were observated. Result The results of 5_week experiment had shown: 1. In normal mice fed with SF, the blood sugar level was decreased (P<0.05). There were no obvious changes in serum total cholesterol (TC) and the triglyceride (TG). The high_density_lipoprotein cholesterol (HDL_C) level was increased significantly (P<0.05); 2. Among DM mice, blood sugar was decreased considerably (P<0.001), TC and TG also decreased noticeably (P<0.05), HDL_C increased clearly (P<0.05); 3. SF has a protective role to the liver and kidney of DM mice. Conclusion It is suggested that SF has the function of decreasing blood sugar, blood_lipid and improving their metabolism, and of protecting liver and kidney of DM mice.

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