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Articles in press have been peer-reviewed and accepted, which are not yet assigned to volumes/issues, but are citable by Digital Object Identifier (DOI).
Original Article
Follow-up of 3- to 24-month on COVID-19 with Pulmonary Tuberculosis Survivors after Discharge: Results from a Prospective, Multi-center Study
WANG Jing Ya, ZONG Xing Yu, WU Gui Hui, QI Yuan Lin, LI Hui Zhen, JI Xin Yu, TONG Lin, ZHANG Lei, YANG Ming Bo, YANG Pu Ye, LI Ji Ke, XIAO Fu Rong, ZHANG Lin Song, HU Yun Hong, LIU Hong De, XU Shou Fang, SUN Sheng, WU Wei, MAO Ya, LI Min Qing, HOU Hao Huau, GONG Zhao Yuan, GUO Yang, JIAO Li Wen, QIN Jin, WANG Ding Yi, WANG Fang, GUAN Li, LIN Gang, MA Yan, WANG Yan Ping, SHI Nan Nan
, Available online  , doi: 10.3967/bes2022.126
  Objective  Coronavirus disease 2019 (COVID-19) and tuberculosis (TB) are major public health and social issues worldwide. Long term follow-up of COVID-19 with pulmonary TB(PTB) survivors after discharge is unclear. This study aimed to comprehensively describe clinical outcome including sequela and recurrence at 3-,12-, and 24-month after discharge among COVID-19 survivors with PTB.   Methods  A prospective, multi-center follow-up study was conducted on COVID-19 with PTB survivors after discharge in 13 hospitals from 4 provinces in China from January 22, 2020 to May 6, 2022, with a follow-up by August 26, 2022. Clinical outcome including sequelae, recurrence of COVID-19 and PTB survivors were collected via telephone and face-to face interview at 3-, 12-, and 24-month after discharge.   Results  A total of 32 COVID-19 with PTB survivors were included. The median age was 52 (45, 59) years, and 23 (71.9%) were males. Among them, nearly two thirds (62.5%) of the survivors were moderate and 3 (9.4%) severe, more than half (59.4%) had at least comorbidity (PTB excluded). The proportion of COVID-19 survivors with at least one sequelae symptom decreased from 40.6% at 3-month to 15.8% at 24-month, with anxiety had higher proportion over follow-up. Cough and amnesia recovered at 12-month follow-up, while anxiety, fatigue, and difficulty falling asleep remained after 24 months. Additionally, 1 (3.1%) case occurred two recurrences of PTB, and no re-positive COVID-19 during follow-up period.   Conclusions  Proportion of the long symptoms in COVID-19 with PTB survivors decreased over time while nearly one in six still experience persistent symptoms with higher proportion of anxiety. More attention should be paid to the recurrence of PTB and the psychological support of COVID-19 with PTB after discharge.
Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease Risk among Chinese Adults
ZHAO Hui, QIU Xia, LI Hua Zi, CUI Jia Jia, SUN Yong Ye
, Available online  , doi: 10.3967/bes2022.111
  Objective   The aim of this case–control study was to explore the association between serum uric acid to high density lipoprotein cholesterol ratio (UHR) and the risk of nonalcoholic fatty liver disease (NAFLD) in Chinese adults.  Methods   A total of 636 patients with NAFLD and 754 controls were enrolled from the Affiliated Hospital of Qingdao University, China, between January and December 2016. All patients completed a comprehensive questionnaire survey and underwent abdominal ultrasound examination and a blood test. NAFLD was diagnosed using ultrasonography after other etiologies were excluded. Logistic regression and restricted cubic spline model were conducted to evaluate the relationship of UHR with NAFLD risk.  Results   The multivariable adjusted odds ratio (95% confidence interval, CI) for NAFLD in the highest versus lowest quartile of UHR was 3.888 (2.324–6.504). In analyses stratified by sex and age, we observed significant and positive associations between UHR and the risk of NAFLD in each subgroup. In analyses stratified by body mass index (BMI), a significant and positive association was found only in individuals with a BMI of ≥ 24 kg/m2. Our dose–response analysis indicated a linear positive correlation between UHR and the risk of NAFLD.  Conclusions   UHR is positively associated with the risk of NAFLD and may serve as an innovative and noninvasive marker for identifying individuals at risk of NAFLD.