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2022, 35(7).  
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2022, 35(7): 1-2.  
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Special Report
Report on Cardiovascular Health and Diseases in China 2021: An Updated Summary
The Writing Committee of the Report on Cardiovascular Health and Diseases in China
2022, 35(7): 573-603.   doi: 10.3967/bes2022.079
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In 2019, cardiovascular disease (CVD) accounted for 46.74% and 44.26% of all deaths in rural and urban areas, respectively. Two out of every five deaths were due to CVD. It is estimated that about 330 million patients suffer from CVD in China. The number of patients suffering from stroke, coronary heart disease, heart failure, pulmonary heart disease, atrial fibrillation, rheumatic heart disease, congenital heart disease, lower extremity artery disease and hypertension are 13.00 million, 11.39 million, 8.90 million, 5.00 million, 4.87 million, 2.50 million, 2.00 million, 45.30 million, and 245.00 million, respectively. Given that China is challenged by the dual pressures of population aging and steady rise in the prevalence of metabolic risk factors, the burden caused by CVD will continue to increase, which has set new requirements for CVD prevention and treatment and the allocation of medical resources in China. It is important to reduce the prevalence through primary prevention, increase the allocation of medical resources for CVD emergency and critical care, and provide rehabilitation services and secondary prevention to reduce the risk of recurrence, re-hospitalization and disability in CVD survivors. The number of people suffering from hypertension, dyslipidemia and diabetes in China has reached hundreds of millions. Since blood pressure, blood lipids, and blood glucose levels rise mostly insidiously, vascular disease or even serious events such as myocardial infarction and stroke often already occured at the time of detection in this population. Hence, more strategies and tasks should be taken to prevent risk factors such as hypertension, dyslipidemia, diabetes, obesity, and smoking, and more efforts should be made in the assessment of cardiovascular health status and the prevention, treatment, and research of early pathological changes.
Original Article
Waist Circumference of the Elderly over 65 Years Old in China Increased Gradually from 1993 to 2015: A Cohort Study
YANG Xin Li, OUYANG Yi Fei, ZHANG Xiao Fan, SU Chang, BAI Jing, ZHANG Bing, HONG Zhong Xin, DU Shu Fa, WANG Hui Jun
2022, 35(7): 604-612.   doi: 10.3967/bes2022.080
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  Objective  This study aimed to analyze the temporal trends and characteristics associated with waist circumference (WC) among elderly Chinese people.  Methods  We used data from 3,096 adults ≥ 65 years who participated in the China Health and Nutrition Survey (CHNS), an ongoing cohort study, between 1993 and 2015. We used longitudinal quantile regression models to explore the temporal trends and characteristics associated with WC.  Results  WC increased gradually among the elderly Chinese population during the survey. The WC curves shifted to the right with wider distributions and lower peaks in men and women. All WC percentile curves shifted upward with similar growth rates in the 25th, 50th, and 75th percentiles. The WC means increased from 78 cm to 86 cm during the 22 years of our study. WC significantly increased with age and body mass index and decreased with physical activity (PA). These associations were stronger in the higher percentiles than in the lower percentiles.  Conclusions  WC is rising among Chinese adults ≥ 65 years. Factors affecting WC in elderly people may have different effects on different percentiles of the WC distribution, and PA was the most important protective factor in the higher percentiles of the WC distribution. Thus, different interventional strategies are needed.
The Influence of Diabetes, Hypertension, and Hyperlipidemia on the Onset of Age-Related Macular Degeneration in North China: The Kailuan Eye Study
ZHANG Yong Peng, WANG Ya Xing, ZHOU Jin Qiong, WANG Qian, YAN Yan Ni, YANG Xuan, YANG Jing Yan, ZHOU Wen Jia, WANG Ping, SHEN Chang, YANG Ming, LUAN Ya Nan, WANG Jin Yuan, WU Shou Ling, CHEN Shuo Hua, WANG Hai Wei, FANG Li Jian, WAN Qian Qian, ZHU Jing Yuan, NIE Zi Han, CHEN Yu Ning, XIE Ying, JONAS JB, WEI Wen Bin
2022, 35(7): 613-621.   doi: 10.3967/bes2022.081
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  Objective   To analyze the prevalence of dry and wet age-related macular degeneration (AMD) in patients with diabetes, hypertension and hyperlipidemia, and to analyze the risk factors for AMD.  Methods  A population-based cross-sectional epidemiologic study was conducted involving 14,440 individuals. We assessed the prevalence of dry and wet AMD in diabetic and non-diabetic subjects and analyzed the risk factors for AMD.  Results  The prevalence of wet AMD in diabetic and non-diabetic patients was 0.3% and 0.5%, respectively, and the prevalence of dry AMD was 17% and 16.4%, respectively. The prevalence of wet AMD in healthy, hypertensive, hyperlipidemic, and hypertensive/hyperlipidemic populations was 0.5%, 0.3%, 0.2%, and 0.7%, respectively. The prevalence of dry AMD in healthy, hypertensive, hyperlipidemic, and hypertensive/hyperlipidemic populations was 16.6%, 16.2%, 15.2%, and 17.2%, respectively. Age, sex, body mass index, and use of hypoglycemic drugs or lowering blood pressure drugs were corrected in the risk factor analysis of AMD. Diabetes, diabetes/hypertension, diabetes/hyperlipidemia, and diabetes/hypertension/hyperlipidemia were analyzed. None of the factors analyzed in the current study increased the risk for the onset of AMD.  Conclusion  There was no significant difference in the prevalence of wet and dry AMD among diabetic and non-diabetic subjects. Similarly, there was no significant difference in the prevalence of wet and dry AMD among subjects with hypertension and hyperlipidemia. Diabetes co-existing with hypertension and hyperlipidemia were not shown to be risk factors for the onset of dry AMD.
Overexpression of Protein Phosphatase 2 Regulatory Subunit B"Alpha Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular Carcinoma
JIAO Ning, JI Wan Sheng, ZHANG Biao, SHANG Yu Kui, ZHANG Yu Chen, YU Wei Qun, JIN Hai Long, LI Chao, ZHANG Cheng Ying, YAN Cheng, YUE Wen, ZHANG Qing
2022, 35(7): 622-632.   doi: 10.3967/bes2022.082
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  Objective   To investigate the regulatory relationship of Protein Phosphatase 2 Regulatory Subunit B'Alpha (PPP2R3A) and hexokinase 1 (HK1) in glycolysis of hepatocellular carcinoma (HCC).   Methods   In HepG2 and Huh7 cells, PPP2R3A expression was silenced by small interfering RNA (siRNA) and overexpression by plasmid transfection. The PPP2R3A-related genes were searched by RNA sequencing. Glycolysis levels were measured by glucose uptake and lactate production. QRT-PCR, ELISA, western blot and immunofluorescence assay were performed to detect the changes of PPP2R3A and HK1. Cell proliferation, migration and invasion assay were used to study the roles of HK1 regulation by PPP2R3A.   Results   RNA sequencing data revealed that PPP2R3A siRNA significantly downregulated the expression of HK1. PPP2R3A gene overexpression promotes, while gene silencing suppresses, the level of HK1 and glycolysis in HCC cells. In HCC tissue samples, PPP2R3A and HK1 were colocalized in the cytoplasm, and their expression showed a positive correlation. HK1 inhibition abrogated the promotion of glycolysis, proliferation, migration and invasion by PPP2R3A overexpression in liver cancer cells.   Conclusion   Our findings showed the correlation of PPP2R3A and HK1 in the glycolysis of HCC, which reveals a new mechanism for the oncogenic roles of PPP2R3A in cancer.
Data Resource Profile: A Protocol of China National Diabetic Chronic Complications Study
HOU Xu Hong, WANG Li Min, CHEN Si Yu, LIANG Ye Bei, ZHANG Mei, HUANG Zheng Jing, CHEN Hong Li, WU Jing Zhu, WU Jing, JIA Wei Ping
2022, 35(7): 633-640.   doi: 10.3967/bes2022.078
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Letter to the Editor
Effect of Iodine Supplementation on Iodine Nutrition and Thyroid Function in Pregnant Women: A Cross-Sectional Study
SUN Rong, QIAN Ting Ting, LIU Lan Chun, ZHAO Meng, CHE Wen Jing, ZHANG Ling, LI Wei Dong, JIA Qing Zhen, WANG Jian Hui, LI Jin Shu, CHEN Zhi Hui, ZHANG Bi Yun, LIU Peng
2022, 35(7): 641-647.   doi: 10.3967/bes2022.083
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Correlation between Anxiety, Depression, and Sleep Quality in College Students
ZHANG Yu Tong, HUANG Tao, ZHOU Fang, HUANG Ao Di, JI Xiao Qi, HE Lu, GENG Qiang, WANG Jia, MEI Can, XU Yu Jia, YANG Ze Long, ZHAN Jian Bo, CHENG Jing
2022, 35(7): 648-651.   doi: 10.3967/bes2022.084
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The putative NAD(P)H Nitroreductase, Rv3131, is the Probable Activating Enzyme for Metronidazole in Mycobacterium Tuberculosis
DONG Wen Zhu, SHI Jin, CHU Ping, LIU Rong Mei, WEN Shu An, ZHANG Ting Ting, PANG Yu, LU Jie
2022, 35(7): 652-656.   doi: 10.3967/bes2022.085
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Oxidative Damage to BV2 Cells by Trichloroacetic Acid: Protective Role of Boron via the p53 Pathway
WANG Chong, HUANG Wei, LI Li, WANG Chao, SHI Ying, TANG Song, GU Wen, XU Yong Jun, ZHANG Li Xia, ZHANG Ming, DUAN Lian, ZHAO Kang Feng
2022, 35(7): 657-662.   doi: 10.3967/bes2022.086
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This study aimed to investigate the neurotoxicity induced by trichloroacetic acid (TCA) and the possible protective mechanisms of boron (B). Mouse BV2 cells were treated with TCA (0, 0.39, 0.78, 1.56, 3.12, 6.25, or 12.5 mmol/L) and B (0, 7.8, 15.6, 31.25, 62.5, 125, 500, or 1,000 mmol/L) for 3 h and 24 h, respectively. Then, reactive oxygen species, and supernatant proinflammatory cytokine and protein levels were analyzed after 24 h of combined exposure. Beyond the dose-dependent decrease in the cellular viability, it clearly increased after B supplementation (P < 0.05). Moreover, B decreased oxidative damage, and significantly down-regulated IL-6 levels and up-regulated TNF-β production (P < 0.05). B also decreased apoptosis via the p53 pathway. The present findings indicated that TCA may induce oxidative damage, whereas B mitigates these adverse effects by decreasing cell apoptosis.
Expression of Thioredoxin System Protein Induced by Silica in Rat Lung Tissue
GUAN Yi, LI Gai, LIU Nan, WANG Yong Heng, ZHOU Qiang, CHANG Mei Yu, ZHAO Lin Lin, YAO San Qiao
2022, 35(7): 663-668.   doi: 10.3967/bes2022.087
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Oyster Protein Hydrolysate Alleviates Cadmium Toxicity by Restoring Cadmium-Induced Intestinal Damage and Gut Microbiota Dysbiosis in Mice via Its Abundance of Methionine, Tyrosine, and Glutamine
WANG Jing Wen, FANG Zhi Jia, LI Yong Bin, HUANG Lin Ru, SUN Li Jun, LIU Ying, WANG Ya Ling, LIAO Jian Meng
2022, 35(7): 669-673.   doi: 10.3967/bes2022.088
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Periodontal Ligament Stem Cells Reverse the High Glucose Level-Induced Inflammatory State of Macrophages
LIU Yun Xia, DING Xiao Ling, TANG Shuai, CUI Shu Yue, LIU Jia Jia, DING Gang
2022, 35(7): 674-679.   doi: 10.3967/bes2022.089
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2022, 35(7): 680-680.  
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Bone Injury and Fracture Healing Biology
Ahmad Oryan, Somayeh Monazzah, Amin Bigham-Sadegh
2015, 28(1): 57-71.   doi: 10.3967/bes2015.006
[Abstract](5918) [PDF 3875KB](2312)
The Serum Exosome Derived MicroRNA-135a, -193b, and-384 Were Potential Alzheimer's Disease Biomarkers
YANG Ting Ting, LIU Chen Geng, GAO Shi Chao, ZHANG Yi, WANG Pei Chang
2018, 31(2): 87-96.   doi: 10.3967/bes2018.011
[Abstract](5627) [FullText HTML](1649) [PDF 11333KB](1649)
Burden of Cirrhosis and Other Chronic Liver Diseases Caused by Specific Etiologies in China, 1990−2016: Findings from the Global Burden of Disease Study 2016
LI Man, WANG Zhuo Qun, ZHANG Lu, ZHENG Hao, LIU Dian Wu, ZHOU Mai Geng
2020, 33(1): 1-10.   doi: 10.3967/bes2020.001
[Abstract](4582) [FullText HTML](1255) [PDF 2552KB](1255)
Stability of SARS Coronavirus in Human Specimens and Environment and Its Sensitivity to Heating and UV Irradiation
2003, 16(3): 246-255.  
[Abstract](5897) [PDF 610KB](1218)
Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province, China
MAO Gen Xiang, LAN Xiao Guang, CAO Yong Bao, CHEN Zhuo Mei, HE Zhi Hua, LV Yuan Dong, WANG Ya Zhen, HU Xi Lian, WANG Guo Fu, YAN Jing
2012, 25(3): 317-324.   doi: 10.3967/0895-3988.2012.03.010
[Abstract](3182) [PDF 528KB](1178)
Evaluating the Nutritional Status of Oncology Patientsand Its Association with Quality of Life
ZHANG Ya Hui, XIE Fang Yi, CHEN Ya Wen, WANG Hai Xia, TIAN Wen Xia, SUN Wen Guang, WU Jing
2018, 31(9): 637-644.   doi: 10.3967/bes2018.088
[Abstract](4081) [FullText HTML](912) [PDF 31943KB](912)
Metabolomic Profiling Differences among Asthma, COPD, and Healthy Subjects: A LC-MS-based Metabolomic Analysis
LIANG Ying, GAI Xiao Yan, CHANG Chun, ZHANG Xu, WANG Juan, LI Ting Ting
2019, 32(9): 659-672.   doi: 10.3967/bes2019.085
[Abstract](3433) [FullText HTML](765) [PDF 2914KB](765)
Supplementation of Fermented Barley Extracts with Lactobacillus Plantarum dy-1 Inhibits Obesity via a UCP1-dependent Mechanism
XIAO Xiang, BAI Juan, LI Ming Song, ZHANG Jia Yan, SUN Xin Juan, DONG Ying
2019, 32(8): 578-591.   doi: 10.3967/bes2019.076
[Abstract](3514) [FullText HTML](605) [PDF 9101KB](605)
Protein Requirements in Healthy Adults:A Meta-analysis of Nitrogen Balance Studies
LI Min, SUN Feng, PIAO Jian Hua, YANG Xiao Guang
2014, 27(8): 606-613.   doi: 10.3967/bes2014.093
[Abstract](2541) [PDF 8784KB](922)
Resveratrol Induces Apoptosis and Autophagy in T-cell Acute Lymphoblastic Leukemia Cells by Inhibiting Akt/mTOR and Activating p38-MAPK
GE Jiao, LIU Yan, LI Qiang, GUO Xia, GU Ling, MA Zhi Gui, ZHU Yi Ping
2013, 26(11): 902-911.   doi: 10.3967/bes2013.019
[Abstract](3318) [PDF 12143KB](619)
2022, 35(6): 1-2.  
[Abstract](851) [FullText HTML](17) [PDF 164KB](17)
The Emergence, Epidemiology, and Etiology of Haff Disease
PEI Pei, LI Xiao Yan, LU Shuang Shuang, LIU Zhe, WANG Rui, LU Xuan Cheng, LU Kai
2019, 32(10): 769-778.   doi: 10.3967/bes2019.096
[Abstract](3260) [FullText HTML](1251) [PDF 2249KB](1251)
Protective Effect of Angiotensin (1-7) on Silicotic Fibrosis in Rats
ZHANG Bo Nan, XU Hong, GAO Xue Min, ZHANG Gui Zhen, ZHANG Xin, YANG Fang
2019, 32(6): 419-426.   doi: 10.3967/bes2019.057
[Abstract](2400) [PDF 1328KB](512)
Health Effect of Forest Bathing Trip on Elderly Patients with Chronic Obstructive Pulmonary Disease
JIA Bing Bing, YANG Zhou Xin, MAO Gen Xiang, LYU Yuan Dong, WEN Xiao Lin, XU Wei Hong, LYU XIAO Ling
2016, 29(3): 212-218.   doi: 10.3967/bes2016.026
[Abstract](1586) [PDF 803KB](538)
Hypertension Prevalence, Awareness, Treatment, and Control and Their Associated Socioeconomic Factors in China: A Spatial Analysis of A National Representative Survey
WANG Wei, ZHANG Mei, XU Cheng Dong, YE Peng Peng, LIU Yun Ning, HUANG Zheng Jing, HU Cai Hong, ZHANG Xiao, ZHAO Zhen Ping, LI Chun, CHEN Xiao Rong, WANG Li Min, ZHOU Mai Geng
2021, 34(12): 937-951.   doi: 10.3967/bes2021.130
[Abstract](679) [FullText HTML](292) [PDF 2205KB](292)
Mutual Impact of Diabetes Mellitus and Tuberculosis in China
CHENG Jun, ZHANG Hui, ZHAO Yan Lin, WANG Li Xia, CHEN Ming Ting
2017, 30(5): 384-389.   doi: 10.3967/bes2017.051
[Abstract](2775) [FullText HTML](838) [PDF 671KB](838)
Inactivation of Poliovirus by Ozone and the Impact of Ozone on the Viral Genome
JIANG Han Ji, CHEN Na, SHEN Zhi Qiang, YIN Jing, QIU Zhi Gang, MIAO Jing, YANG Zhong Wei, SHI Dan Yang, WANG Hua Ran, WANG Xin Wei, LI Jun Wen, YANG Dong, JIN Min
2019, 32(5): 324-333.   doi: 10.3967/bes2019.044
[Abstract](3338) [FullText HTML](729) [PDF 2666KB](729)
Exposure Effects of Terahertz Waves on Primary Neurons and Neuron-like Cells Under Nonthermal Conditions
TAN Sheng Zhi, TAN Peng Cheng, LUO Lan Qing, CHI Yun Liang, YANG Zi Long, ZHAO Xue Long, ZHAO Li, DONG Ji, ZHANG Jing, YAO Bin Wei, XU Xin Ping, TIAN Guang, CHEN Jian Kui, WANG Hui, PENG Rui Yun
2019, 32(10): 739-754.   doi: 10.3967/bes2019.094
[Abstract](3023) [FullText HTML](814) [PDF 3322KB](814)
TaqMan Real-time RT-PCR Assay for Detecting and Differentiating Japanese Encephalitis Virus
SHAO Nan, LI Fan, NIE Kai, FU Shi Hong, ZHANG Wei Jia, HE Ying, LEI Wen Wen, WANG Qian Ying, LIANG Guo Dong, CAO Yu Xi, WANG Huan Yu
2018, 31(3): 208-214.   doi: 10.3967/bes2018.026
[Abstract](2144) [FullText HTML](699) [PDF 4691KB](699)
Trends in Lipids Level and Dyslipidemia among Chinese Adults, 2002-2015
SONG Peng Kun, MAN Qing Qing, LI Hong, PANG Shao Jie, JIA Shan Shan, LI Yu Qian, HE Li, ZHAO Wen Hua, ZHANG Jian
2019, 32(8): 559-570.   doi: 10.3967/bes2019.074
[Abstract](3129) [FullText HTML](743) [PDF 3641KB](743)

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Vol 35, No 7

(July, 2022)

ISSN 0895-3988

CN 11-2816/Q

  • 2021 Impact Factor 2.831

  • 2021 Journal Citation Reports