Induction of Chromosomal Aberrations by Propoxur in Mouse Bone Marrow Ceils

R.C.AGRAWAL

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Volume 12 Issue 4

Dec. 1999

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Article Navigation > Biomedical and Environmental Sciences > 1999 > 12(4): 292-295

R.C.AGRAWAL. Induction of Chromosomal Aberrations by Propoxur in Mouse Bone Marrow Ceils[J]. Biomedical and Environmental Sciences, 1999, 12(4): 292-295.

Citation:

R.C.AGRAWAL. Induction of Chromosomal Aberrations by Propoxur in Mouse Bone Marrow Ceils[J]. Biomedical and Environmental Sciences, 1999, 12(4): 292-295.

Induction of Chromosomal Aberrations by Propoxur in Mouse Bone Marrow Ceils

R.C.AGRAWAL

Laboratory of Environmental Carcinogenesis, Industrial Toxicology Research Centre, Post Box No. 80, Mahatma Gandhi Marg, Lucknow, India

Abstract

Propoxur is a widely used dithiocarbamate insecticide. In this study, the clastogenic effect of propoxur has been evaluated using chromosomal aberration assay in mouse bone marrow cells. Singlei. p. administration of propoxur, at 25 nag/kg b.wt., a maximum tolerated dose (MTD) and 12.5mg/kg b.wt (50% of MTD) have significantly induced different types of aberrations after 24 h of treatment. The aberrations were dose and time dependent and reached a maximum after 24 h of exposure. The sresult suggest a genotoxic potential of propoxur.
- chromosomal aberration,
- bone marrow cells
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沈阳化工大学材料科学与工程学院沈阳 110142

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Induction of Chromosomal Aberrations by Propoxur in Mouse Bone Marrow Ceils

R.C.AGRAWAL

Laboratory of Environmental Carcinogenesis, Industrial Toxicology Research Centre, Post Box No. 80, Mahatma Gandhi Marg, Lucknow, India

Key words:

chromosomal aberration /
bone marrow cells

Abstract: Propoxur is a widely used dithiocarbamate insecticide. In this study, the clastogenic effect of propoxur has been evaluated using chromosomal aberration assay in mouse bone marrow cells. Singlei. p. administration of propoxur, at 25 nag/kg b.wt., a maximum tolerated dose (MTD) and 12.5mg/kg b.wt (50% of MTD) have significantly induced different types of aberrations after 24 h of treatment. The aberrations were dose and time dependent and reached a maximum after 24 h of exposure. The sresult suggest a genotoxic potential of propoxur.

R.C.AGRAWAL. Induction of Chromosomal Aberrations by Propoxur in Mouse Bone Marrow Ceils[J]. Biomedical and Environmental Sciences, 1999, 12(4): 292-295.

Citation:

R.C.AGRAWAL. Induction of Chromosomal Aberrations by Propoxur in Mouse Bone Marrow Ceils[J]. Biomedical and Environmental Sciences, 1999, 12(4): 292-295.