Volume 15 Issue 1
Mar.  2002
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SUN Hong-xia, ZHANG KUI-XING, DU WEI-NAN, SHI JIN-XIU, JIANG ZHENG-WEN, SUN HAO, ZUO JIN, HUANG WEI, CHEN ZHU, SHEN YAN, YAO Zhi-Jian, QIANG Bo-Qin, FANG FU-DE. Single Nucleotide Polymorphisms in CAPN10 Gene of Chinese People and Its Correlation With Type 2 Diabetes Mellitus in Han People of Northern China[J]. Biomedical and Environmental Sciences, 2002, 15(1): 75-82.
Citation: SUN Hong-xia, ZHANG KUI-XING, DU WEI-NAN, SHI JIN-XIU, JIANG ZHENG-WEN, SUN HAO, ZUO JIN, HUANG WEI, CHEN ZHU, SHEN YAN, YAO Zhi-Jian, QIANG Bo-Qin, FANG FU-DE. Single Nucleotide Polymorphisms in CAPN10 Gene of Chinese People and Its Correlation With Type 2 Diabetes Mellitus in Han People of Northern China[J]. Biomedical and Environmental Sciences, 2002, 15(1): 75-82.

Single Nucleotide Polymorphisms in CAPN10 Gene of Chinese People and Its Correlation With Type 2 Diabetes Mellitus in Han People of Northern China

Funds:  国家自然科学基金(Grant 30170441,39896200)%国家高技术研究发展计划(863计划)(Grant 2001AA221161)%国家重点基础研究发展计划(973计划)(Grant G1998051016)%北京市自然科学基金(Grant 7002026)%the National High Education Science Fund(Grant 20010023024)
  • To investigate the distribution of single nucleotide polymorphisms (SNPs) in CAPN10 gene in Chinese population and their relation with type 2 diabetes mellitus in Han people of Northern China. Methods CAPN10 gene was sequenced to detect SNPs in different nationalities of China. Five SNPs were chosen to perform case-control study and haplotype analysis in 156 normal Han people of Northern China and 173 type 2 diabetes. One SNP was also analyzed with transmission-disequilibrium test (TDT) and sib transmissiondisequilibrium test (STDT) in 68 type 2 diabetes pedigrees (37Tpeople). Results A total of 40 SNPs were identified in length of 8 936bp, with an average of 1 in every 223bp. The SNPs in CAPN10 gene did not distribute evenly and the SNPs in Chinese were different from those reported in Mexican American. There was no significantly statistical difference in the allele frequency of the 5 SNPs between case and control, and the haplotype frequencies in the two groups were not significantly different. No positive results was found in TDT and STDT analysis. Conclusions The SNP distribution of CAPN10 gene differs in different nationalities. The studied SNPs in CAPN10 gene may not be the major susceptibility ones of type 2 diabetes mellitus in Han people of Northern China.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Single Nucleotide Polymorphisms in CAPN10 Gene of Chinese People and Its Correlation With Type 2 Diabetes Mellitus in Han People of Northern China

Funds:  国家自然科学基金(Grant 30170441,39896200)%国家高技术研究发展计划(863计划)(Grant 2001AA221161)%国家重点基础研究发展计划(973计划)(Grant G1998051016)%北京市自然科学基金(Grant 7002026)%the National High Education Science Fund(Grant 20010023024)

Abstract: To investigate the distribution of single nucleotide polymorphisms (SNPs) in CAPN10 gene in Chinese population and their relation with type 2 diabetes mellitus in Han people of Northern China. Methods CAPN10 gene was sequenced to detect SNPs in different nationalities of China. Five SNPs were chosen to perform case-control study and haplotype analysis in 156 normal Han people of Northern China and 173 type 2 diabetes. One SNP was also analyzed with transmission-disequilibrium test (TDT) and sib transmissiondisequilibrium test (STDT) in 68 type 2 diabetes pedigrees (37Tpeople). Results A total of 40 SNPs were identified in length of 8 936bp, with an average of 1 in every 223bp. The SNPs in CAPN10 gene did not distribute evenly and the SNPs in Chinese were different from those reported in Mexican American. There was no significantly statistical difference in the allele frequency of the 5 SNPs between case and control, and the haplotype frequencies in the two groups were not significantly different. No positive results was found in TDT and STDT analysis. Conclusions The SNP distribution of CAPN10 gene differs in different nationalities. The studied SNPs in CAPN10 gene may not be the major susceptibility ones of type 2 diabetes mellitus in Han people of Northern China.

SUN Hong-xia, ZHANG KUI-XING, DU WEI-NAN, SHI JIN-XIU, JIANG ZHENG-WEN, SUN HAO, ZUO JIN, HUANG WEI, CHEN ZHU, SHEN YAN, YAO Zhi-Jian, QIANG Bo-Qin, FANG FU-DE. Single Nucleotide Polymorphisms in CAPN10 Gene of Chinese People and Its Correlation With Type 2 Diabetes Mellitus in Han People of Northern China[J]. Biomedical and Environmental Sciences, 2002, 15(1): 75-82.
Citation: SUN Hong-xia, ZHANG KUI-XING, DU WEI-NAN, SHI JIN-XIU, JIANG ZHENG-WEN, SUN HAO, ZUO JIN, HUANG WEI, CHEN ZHU, SHEN YAN, YAO Zhi-Jian, QIANG Bo-Qin, FANG FU-DE. Single Nucleotide Polymorphisms in CAPN10 Gene of Chinese People and Its Correlation With Type 2 Diabetes Mellitus in Han People of Northern China[J]. Biomedical and Environmental Sciences, 2002, 15(1): 75-82.

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