Effects of Nicotinamide on Mouse Skin Tumor Development and lts Mode of Action

KRISHNA P.GUPTA

PDF
Cite
Share

facebook

twitter

google

linkedin

Volume 12 Issue 3

Sep. 1999

Turn off MathJax

Article Contents

Article Navigation > Biomedical and Environmental Sciences > 1999 > 12(3): 177-187

KRISHNA P.GUPTA. Effects of Nicotinamide on Mouse Skin Tumor Development and lts Mode of Action[J]. Biomedical and Environmental Sciences, 1999, 12(3): 177-187.

Citation:

KRISHNA P.GUPTA. Effects of Nicotinamide on Mouse Skin Tumor Development and lts Mode of Action[J]. Biomedical and Environmental Sciences, 1999, 12(3): 177-187.

Effects of Nicotinamide on Mouse Skin Tumor Development and lts Mode of Action

KRISHNA P.GUPTA

Environmental Carcinogenesis Section, Industrial Toxicology Research Centre,Post Box No. 80, Mahatma Gandhi Mang, Lucknow-226 001, India

Abstract

Nicotinamide (NA), a naturally occuring vitamin and a protease inhibitor, has been shown to be effective in treating some skin ailments. It inhibits cell proliferation and induces cell differentiation. This report shows the effects of NA on mouse skin tumor development and on the critical events involved in this process. NA reduced tumor growth, inhibited the 12-O-tetradecanoylphorbol- 13-acetate (TPA) induced ornithine decarboxylase activity, but induced the transglutaminase activity which was inhibited by TPA under different experimental conditions.The effects of NA on ornithine decarboxylase (ODC) and transglutaminase (TG) indicated that nicotinamide (NA) probably programmmed the cells for their death in the natural course of time, I.e. Programed cell death. This observation indicates that NA might be a better agent for the detailed study and for the better use in prevention of cancer alone or in combination with other drugs.
- Mode of Action,
- ornithine decarboxylase,
- cell differentiation,
- protease inhibitor,
- cell proliferation,
- prevention of,
- tumor growth,
- skin tumor,
- cell death
References
Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views(1313) PDF downloads(4) Cited by()

Proportional views

Effects of Nicotinamide on Mouse Skin Tumor Development and lts Mode of Action

KRISHNA P.GUPTA

Environmental Carcinogenesis Section, Industrial Toxicology Research Centre,Post Box No. 80, Mahatma Gandhi Mang, Lucknow-226 001, India

Key words:

Abstract: Nicotinamide (NA), a naturally occuring vitamin and a protease inhibitor, has been shown to be effective in treating some skin ailments. It inhibits cell proliferation and induces cell differentiation. This report shows the effects of NA on mouse skin tumor development and on the critical events involved in this process. NA reduced tumor growth, inhibited the 12-O-tetradecanoylphorbol- 13-acetate (TPA) induced ornithine decarboxylase activity, but induced the transglutaminase activity which was inhibited by TPA under different experimental conditions.The effects of NA on ornithine decarboxylase (ODC) and transglutaminase (TG) indicated that nicotinamide (NA) probably programmmed the cells for their death in the natural course of time, I.e. Programed cell death. This observation indicates that NA might be a better agent for the detailed study and for the better use in prevention of cancer alone or in combination with other drugs.

KRISHNA P.GUPTA. Effects of Nicotinamide on Mouse Skin Tumor Development and lts Mode of Action[J]. Biomedical and Environmental Sciences, 1999, 12(3): 177-187.

Citation:

KRISHNA P.GUPTA. Effects of Nicotinamide on Mouse Skin Tumor Development and lts Mode of Action[J]. Biomedical and Environmental Sciences, 1999, 12(3): 177-187.