Volume 20 Issue 1
Feb.  2007
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CONG-RONG WANG, CHENG HU, RONG ZHANG, QI-CHEN FANG, XIAO-JING MA, WEI-PING JIA, KUN-SAN XIANG. Association of A Common Haplotype of Hepatocyte Nuclear Factor 1α With Type 2 Diabetes in Chinese Population[J]. Biomedical and Environmental Sciences, 2007, 20(1): 41-46.
Citation: CONG-RONG WANG, CHENG HU, RONG ZHANG, QI-CHEN FANG, XIAO-JING MA, WEI-PING JIA, KUN-SAN XIANG. Association of A Common Haplotype of Hepatocyte Nuclear Factor 1α With Type 2 Diabetes in Chinese Population[J]. Biomedical and Environmental Sciences, 2007, 20(1): 41-46.

Association of A Common Haplotype of Hepatocyte Nuclear Factor 1α With Type 2 Diabetes in Chinese Population

Funds:  国家重点基础研究发展计划(973计划)(2006CB503901)%国家重点基础研究发展计划(973计划)(02DJ14052-I)%the Science and Technology Development Foundation of Shanghai Municipal Health Bureau(034043)%the Young Doctor Training Project of Shanghai Municipal Health Bureau
  • Objective To analyze the association of variants of hepatocyte nuclear factor-1α (HNF-1α) gene with type 2 diabetes in Chinese population. Methods In 152 unrelated type 2 diabetes patients and 93 unrelated controls, eleven single nucleotide polymorphisms (SNPs) were identified and genotyped. Statistical analyses were performed to investigate whether these SNPs were associated with diabetes status in our samples. Results In the individual SNP study, no SNP differed significantly in frequency between type 2 diabetes patients and controls. In the haplotype analysis, two haplotype blocks were identified. In haplotype block 1, no evidence was found between common HNF-1α haplotypes and type 2 diabetes. However, in haplotype block 2, a common haplotype GCGC formed by four tagging SNPs (tSNPs) was found to be associated with decreased risk of type 2 diabetes (odds ratio [OR] 0.6011, 95% confidence interval [CI] 0.4138-0.8732,P=0.0073, empirical P=0.0511, permutation test). A similar trend was also observed in the diplotype analysis, indicating that the increasing copy number of the haplotype GCGC was associated with the decreased frequency of diabetes (P=0.0193). Conclusion The results of this study provide evidence that the haplotype of HNF-1α decreases the risk of type 2 diabetes in Chinese individuals.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Association of A Common Haplotype of Hepatocyte Nuclear Factor 1α With Type 2 Diabetes in Chinese Population

Funds:  国家重点基础研究发展计划(973计划)(2006CB503901)%国家重点基础研究发展计划(973计划)(02DJ14052-I)%the Science and Technology Development Foundation of Shanghai Municipal Health Bureau(034043)%the Young Doctor Training Project of Shanghai Municipal Health Bureau

Abstract: Objective To analyze the association of variants of hepatocyte nuclear factor-1α (HNF-1α) gene with type 2 diabetes in Chinese population. Methods In 152 unrelated type 2 diabetes patients and 93 unrelated controls, eleven single nucleotide polymorphisms (SNPs) were identified and genotyped. Statistical analyses were performed to investigate whether these SNPs were associated with diabetes status in our samples. Results In the individual SNP study, no SNP differed significantly in frequency between type 2 diabetes patients and controls. In the haplotype analysis, two haplotype blocks were identified. In haplotype block 1, no evidence was found between common HNF-1α haplotypes and type 2 diabetes. However, in haplotype block 2, a common haplotype GCGC formed by four tagging SNPs (tSNPs) was found to be associated with decreased risk of type 2 diabetes (odds ratio [OR] 0.6011, 95% confidence interval [CI] 0.4138-0.8732,P=0.0073, empirical P=0.0511, permutation test). A similar trend was also observed in the diplotype analysis, indicating that the increasing copy number of the haplotype GCGC was associated with the decreased frequency of diabetes (P=0.0193). Conclusion The results of this study provide evidence that the haplotype of HNF-1α decreases the risk of type 2 diabetes in Chinese individuals.

CONG-RONG WANG, CHENG HU, RONG ZHANG, QI-CHEN FANG, XIAO-JING MA, WEI-PING JIA, KUN-SAN XIANG. Association of A Common Haplotype of Hepatocyte Nuclear Factor 1α With Type 2 Diabetes in Chinese Population[J]. Biomedical and Environmental Sciences, 2007, 20(1): 41-46.
Citation: CONG-RONG WANG, CHENG HU, RONG ZHANG, QI-CHEN FANG, XIAO-JING MA, WEI-PING JIA, KUN-SAN XIANG. Association of A Common Haplotype of Hepatocyte Nuclear Factor 1α With Type 2 Diabetes in Chinese Population[J]. Biomedical and Environmental Sciences, 2007, 20(1): 41-46.

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