DHA Depletion in Rat Brain Is Associated With Impairment on Spatial Learning and Memory

YING XIAO; LING WANG; RUO-JUN XU; ZHEN-YU CHEN

PDF
Cite
Share

facebook

twitter

google

linkedin

Volume 19 Issue 6

Dec. 2006

Turn off MathJax

Article Contents

Article Navigation > Biomedical and Environmental Sciences > 2006 > 19(6): 474-480

YING XIAO, LING WANG, RUO-JUN XU, ZHEN-YU CHEN. DHA Depletion in Rat Brain Is Associated With Impairment on Spatial Learning and Memory[J]. Biomedical and Environmental Sciences, 2006, 19(6): 474-480.

Citation:

YING XIAO, LING WANG, RUO-JUN XU, ZHEN-YU CHEN. DHA Depletion in Rat Brain Is Associated With Impairment on Spatial Learning and Memory[J]. Biomedical and Environmental Sciences, 2006, 19(6): 474-480.

DHA Depletion in Rat Brain Is Associated With Impairment on Spatial Learning and Memory

Food and Nutrition Sciences Programme, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT,Hong Kong, China;Department of Nutrition and Food Hygiene, School of Public Health, Peking University Health Science Center, Beijing, China
Food and Nutrition Division, Department of Zoology, The University of Hong Kong, Hong Kong, China;Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, China
Food and Nutrition Division, Department of Zoology, The University of Hong Kong, Hong Kong, China
Food and Nutrition Sciences Programme, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT,Hong Kong, China

Abstract

Objective To examine the effect of docosahexaenoic acid (DHA) deficiency in brain on spatial learning and memory in rats. Methods Sprague Dawley rats were fed with an n-3 fatty acid deficient diet for two generations to induce DHA depletion in brain. DHA in seven brain regions was analyzed using the gas-liquid chromatography. Morris water maze (MWM) was employed as an assessing index of spatial learning and memory in the n-3 fatty acid deficient adult rats of second generation. Results Feeding an n-3 deficient diet for two generations depleted DHA differently by 39%-63% in the seven brain regions including cerebellum, medulla, hypothalamus, striatum, hippocampus, cortex and midbrain. The MWM test showed that the n-3 deficient rats took a longer time and swam a longer distance to find the escape platform than the n-3 Adq group. Conclusion The spatial learning and memory in adult rats are partially impaired by brain DHA depletion.
- Docosahexaenoic acid,
- Memory,
- Morris water maze,
- Spatial learning
References
Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views(1351) PDF downloads(18) Cited by()

Proportional views

DHA Depletion in Rat Brain Is Associated With Impairment on Spatial Learning and Memory

Food and Nutrition Sciences Programme, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT,Hong Kong, China;Department of Nutrition and Food Hygiene, School of Public Health, Peking University Health Science Center, Beijing, China

Food and Nutrition Division, Department of Zoology, The University of Hong Kong, Hong Kong, China;Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, China

Food and Nutrition Division, Department of Zoology, The University of Hong Kong, Hong Kong, China

Food and Nutrition Sciences Programme, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT,Hong Kong, China

Key words:

Abstract: Objective To examine the effect of docosahexaenoic acid (DHA) deficiency in brain on spatial learning and memory in rats. Methods Sprague Dawley rats were fed with an n-3 fatty acid deficient diet for two generations to induce DHA depletion in brain. DHA in seven brain regions was analyzed using the gas-liquid chromatography. Morris water maze (MWM) was employed as an assessing index of spatial learning and memory in the n-3 fatty acid deficient adult rats of second generation. Results Feeding an n-3 deficient diet for two generations depleted DHA differently by 39%-63% in the seven brain regions including cerebellum, medulla, hypothalamus, striatum, hippocampus, cortex and midbrain. The MWM test showed that the n-3 deficient rats took a longer time and swam a longer distance to find the escape platform than the n-3 Adq group. Conclusion The spatial learning and memory in adult rats are partially impaired by brain DHA depletion.

Citation: