Volume 20 Issue 2
Apr.  2007
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TING-XIN LI, YUN LI. Synergistic Effect of Zinc and Vitamin A on T Cell Functions[J]. Biomedical and Environmental Sciences, 2007, 20(2): 131-134.
Citation: TING-XIN LI, YUN LI. Synergistic Effect of Zinc and Vitamin A on T Cell Functions[J]. Biomedical and Environmental Sciences, 2007, 20(2): 131-134.

Synergistic Effect of Zinc and Vitamin A on T Cell Functions

Funds:  教育部留学回国人员科研启动基金([2005]383)
  • Objective To determine whether supplementation of zinc and vitamin A may improve the function of T cells in human PBMC. Methods T cells were separated and cultured in vitro, supplemented with either Zn or vitamin A alone, or both Zn and vitamin A (10-6 mol/L, 10-5 mol/L, 10-4 mol/L). After harvesting, cell proliferation, cell cycle, apoptosis, expression or function of cell-surface molecules, such as CD3+, CD4+, and CD8+ were detected. Results Higher proliferation level and lower apoptosis level were observed in cells supplemented with both Zn and vitaminA, showing the strongest effect (P<0.05).Zn-supplement increased the CD4+/CD3+ cell percentage, and simultaneously decreased the CD8+/CD3+ cell population.VA-supplement showed the opposite effect in comparison with Zn-supplement. Conclusion T-cell function can be improved,depending on the zinc and/or vitamin A supplemented.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Synergistic Effect of Zinc and Vitamin A on T Cell Functions

Funds:  教育部留学回国人员科研启动基金([2005]383)

Abstract: Objective To determine whether supplementation of zinc and vitamin A may improve the function of T cells in human PBMC. Methods T cells were separated and cultured in vitro, supplemented with either Zn or vitamin A alone, or both Zn and vitamin A (10-6 mol/L, 10-5 mol/L, 10-4 mol/L). After harvesting, cell proliferation, cell cycle, apoptosis, expression or function of cell-surface molecules, such as CD3+, CD4+, and CD8+ were detected. Results Higher proliferation level and lower apoptosis level were observed in cells supplemented with both Zn and vitaminA, showing the strongest effect (P<0.05).Zn-supplement increased the CD4+/CD3+ cell percentage, and simultaneously decreased the CD8+/CD3+ cell population.VA-supplement showed the opposite effect in comparison with Zn-supplement. Conclusion T-cell function can be improved,depending on the zinc and/or vitamin A supplemented.

TING-XIN LI, YUN LI. Synergistic Effect of Zinc and Vitamin A on T Cell Functions[J]. Biomedical and Environmental Sciences, 2007, 20(2): 131-134.
Citation: TING-XIN LI, YUN LI. Synergistic Effect of Zinc and Vitamin A on T Cell Functions[J]. Biomedical and Environmental Sciences, 2007, 20(2): 131-134.

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