Volume 20 Issue 1
Feb.  2007
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HONG WAN, SHAO-DONG ZHANG, JUN-HUA LI. Action of Schwann Cells Implanted in Cerebral Hemorrhage Lesion[J]. Biomedical and Environmental Sciences, 2007, 20(1): 47-51.
Citation: HONG WAN, SHAO-DONG ZHANG, JUN-HUA LI. Action of Schwann Cells Implanted in Cerebral Hemorrhage Lesion[J]. Biomedical and Environmental Sciences, 2007, 20(1): 47-51.

Action of Schwann Cells Implanted in Cerebral Hemorrhage Lesion

Funds:  国家自然科学基金(30370543)%国家自然科学基金(30540450581)
  • Objective To investigate whether there is neogenesis of myelin sheath and neuron after transplantation of Schwann cells into cerebral hemorrhage lesion. Methods Schwann cells were expanded, labeled with BrdU in vitro and transplanted into rat cerebral hemorrhage with blood extracted from femoral artery and then injected into the basal nuclei. Double immunohistochemistry staining and electron microscopy were used to detect the expression of BrdU/MBP and BrdU/GAP-43 and remyelination. Results BrdU/MBP double positive cells could be seen at 1 week up to 16 weeks after transplantation of Schwann cells. Thin remyelination was observed under electron microscope. GAP-43 positive cells appeared after 12 weeks and were found more in Hippocamp. Conclusions Grafted Schwann cells participate in remyelination and promoter nerve restore in rat cerebral hemorrhage.
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通讯作者: 陈斌, bchen63@163.com
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Action of Schwann Cells Implanted in Cerebral Hemorrhage Lesion

Funds:  国家自然科学基金(30370543)%国家自然科学基金(30540450581)

Abstract: Objective To investigate whether there is neogenesis of myelin sheath and neuron after transplantation of Schwann cells into cerebral hemorrhage lesion. Methods Schwann cells were expanded, labeled with BrdU in vitro and transplanted into rat cerebral hemorrhage with blood extracted from femoral artery and then injected into the basal nuclei. Double immunohistochemistry staining and electron microscopy were used to detect the expression of BrdU/MBP and BrdU/GAP-43 and remyelination. Results BrdU/MBP double positive cells could be seen at 1 week up to 16 weeks after transplantation of Schwann cells. Thin remyelination was observed under electron microscope. GAP-43 positive cells appeared after 12 weeks and were found more in Hippocamp. Conclusions Grafted Schwann cells participate in remyelination and promoter nerve restore in rat cerebral hemorrhage.

HONG WAN, SHAO-DONG ZHANG, JUN-HUA LI. Action of Schwann Cells Implanted in Cerebral Hemorrhage Lesion[J]. Biomedical and Environmental Sciences, 2007, 20(1): 47-51.
Citation: HONG WAN, SHAO-DONG ZHANG, JUN-HUA LI. Action of Schwann Cells Implanted in Cerebral Hemorrhage Lesion[J]. Biomedical and Environmental Sciences, 2007, 20(1): 47-51.

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