Association of Gghrelin Polymorphisms with Metabolic Syndrome in Han Nationality Chinese

LING-LING XU; HONG-DING XIANG; CHANG-CHUN QIU; QUN XU

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Volume 21 Issue 3

Jun. 2008

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Article Navigation > Biomedical and Environmental Sciences > 2008 > 21(3): 188-192

LING-LING XU, HONG-DING XIANG, CHANG-CHUN QIU, QUN XU. Association of Gghrelin Polymorphisms with Metabolic Syndrome in Han Nationality Chinese[J]. Biomedical and Environmental Sciences, 2008, 21(3): 188-192.

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LING-LING XU, HONG-DING XIANG, CHANG-CHUN QIU, QUN XU. Association of Gghrelin Polymorphisms with Metabolic Syndrome in Han Nationality Chinese[J]. Biomedical and Environmental Sciences, 2008, 21(3): 188-192.

Association of Gghrelin Polymorphisms with Metabolic Syndrome in Han Nationality Chinese

Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
National Laboratory of Medical Molecular Biology,School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Science,Chinese Academy of Medical Science, Beijing 100005, China

Funds: 首都发展科研项目(2002-1017)

Abstract

Objective To investigate the association of ghrelin gene polymorphisms with metabolic syndrome in Han Nationality Chinese. Methods A total of 240 patients with metabolic syndrome annd 427 adults aged above forty years were recruited. Genotypes were determined by polymerase chain reaction and restriction fragment lengthpolymorphism analysis.Results The allelic frequency of the Leu72Met polymorphismwas 17.3% in the patient group and 11.9% in the control group(x2=7.36, P=0.007). Metabolic syndrome was more prevalent among carriers of the Met72 variant (43.8 vs 33.1%, age- and sex-adjusted odds ratio=1.57, P=0.01). No Arg51Gln variants were found in our study subjects. Conclusion Rather than being associated with its individual components, Leu72Met polymorphism is associated with metabolic syndrome in the Han Nationality Chinese. Arg51Gln polymorphism is rare in the Hart Nationality Chinese.
- Ghrelin,
- Polymorphism,
- Metabolic syndrome,
- the Han Nationality
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Association of Gghrelin Polymorphisms with Metabolic Syndrome in Han Nationality Chinese

Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China

National Laboratory of Medical Molecular Biology,School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Science,Chinese Academy of Medical Science, Beijing 100005, China

Funds: 首都发展科研项目(2002-1017)

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Abstract: Objective To investigate the association of ghrelin gene polymorphisms with metabolic syndrome in Han Nationality Chinese. Methods A total of 240 patients with metabolic syndrome annd 427 adults aged above forty years were recruited. Genotypes were determined by polymerase chain reaction and restriction fragment lengthpolymorphism analysis.Results The allelic frequency of the Leu72Met polymorphismwas 17.3% in the patient group and 11.9% in the control group(x2=7.36, P=0.007). Metabolic syndrome was more prevalent among carriers of the Met72 variant (43.8 vs 33.1%, age- and sex-adjusted odds ratio=1.57, P=0.01). No Arg51Gln variants were found in our study subjects. Conclusion Rather than being associated with its individual components, Leu72Met polymorphism is associated with metabolic syndrome in the Han Nationality Chinese. Arg51Gln polymorphism is rare in the Hart Nationality Chinese.

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