Volume 21 Issue 3
Jun.  2008
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LING-LING XU, HONG-DING XIANG, CHANG-CHUN QIU, QUN XU. Association of Gghrelin Polymorphisms with Metabolic Syndrome in Han Nationality Chinese[J]. Biomedical and Environmental Sciences, 2008, 21(3): 188-192.
Citation: LING-LING XU, HONG-DING XIANG, CHANG-CHUN QIU, QUN XU. Association of Gghrelin Polymorphisms with Metabolic Syndrome in Han Nationality Chinese[J]. Biomedical and Environmental Sciences, 2008, 21(3): 188-192.

Association of Gghrelin Polymorphisms with Metabolic Syndrome in Han Nationality Chinese

Funds:  首都发展科研项目(2002-1017)
  • Objective To investigate the association of ghrelin gene polymorphisms with metabolic syndrome in Han Nationality Chinese. Methods A total of 240 patients with metabolic syndrome annd 427 adults aged above forty years were recruited. Genotypes were determined by polymerase chain reaction and restriction fragment lengthpolymorphism analysis.Results The allelic frequency of the Leu72Met polymorphismwas 17.3% in the patient group and 11.9% in the control group(x2=7.36, P=0.007). Metabolic syndrome was more prevalent among carriers of the Met72 variant (43.8 vs 33.1%, age- and sex-adjusted odds ratio=1.57, P=0.01). No Arg51Gln variants were found in our study subjects. Conclusion Rather than being associated with its individual components, Leu72Met polymorphism is associated with metabolic syndrome in the Han Nationality Chinese. Arg51Gln polymorphism is rare in the Hart Nationality Chinese.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Association of Gghrelin Polymorphisms with Metabolic Syndrome in Han Nationality Chinese

Funds:  首都发展科研项目(2002-1017)

Abstract: Objective To investigate the association of ghrelin gene polymorphisms with metabolic syndrome in Han Nationality Chinese. Methods A total of 240 patients with metabolic syndrome annd 427 adults aged above forty years were recruited. Genotypes were determined by polymerase chain reaction and restriction fragment lengthpolymorphism analysis.Results The allelic frequency of the Leu72Met polymorphismwas 17.3% in the patient group and 11.9% in the control group(x2=7.36, P=0.007). Metabolic syndrome was more prevalent among carriers of the Met72 variant (43.8 vs 33.1%, age- and sex-adjusted odds ratio=1.57, P=0.01). No Arg51Gln variants were found in our study subjects. Conclusion Rather than being associated with its individual components, Leu72Met polymorphism is associated with metabolic syndrome in the Han Nationality Chinese. Arg51Gln polymorphism is rare in the Hart Nationality Chinese.

LING-LING XU, HONG-DING XIANG, CHANG-CHUN QIU, QUN XU. Association of Gghrelin Polymorphisms with Metabolic Syndrome in Han Nationality Chinese[J]. Biomedical and Environmental Sciences, 2008, 21(3): 188-192.
Citation: LING-LING XU, HONG-DING XIANG, CHANG-CHUN QIU, QUN XU. Association of Gghrelin Polymorphisms with Metabolic Syndrome in Han Nationality Chinese[J]. Biomedical and Environmental Sciences, 2008, 21(3): 188-192.

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