In Vitro Anti-HIV Activity of a Chinese Fungus Extract

ZI-CHUN XIANG; YAN JIANG; SHUN-XING GUO

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Volume 19 Issue 3

Jun. 2006

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Article Navigation > Biomedical and Environmental Sciences > 2006 > 19(3): 169-172

ZI-CHUN XIANG, YAN JIANG, SHUN-XING GUO. In Vitro Anti-HIV Activity of a Chinese Fungus Extract[J]. Biomedical and Environmental Sciences, 2006, 19(3): 169-172.

Citation:

ZI-CHUN XIANG, YAN JIANG, SHUN-XING GUO. In Vitro Anti-HIV Activity of a Chinese Fungus Extract[J]. Biomedical and Environmental Sciences, 2006, 19(3): 169-172.

In Vitro Anti-HIV Activity of a Chinese Fungus Extract

Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing 100094, China
National Center for AIDS/STD Control and Prevention (NCAIDS),Chinese Center for Disease Control and Prevention, Beijing 100050, China

Funds: 国家医药科学基金(2001BA705B01)%国家自然科学基金(30325047)

Abstract

Objective To investigate the inhibitory effect of the mycelium extract from a Chinese fungus (M1) on HIV-1 and its mode of action. Methods Several in vitro methods including time of action, time of addition and PCR were used to test the mode of action of M1. Results M1 inhibited acute HIV infection in vitro and was effective when it was added 12 h after infection. PCR analysis of infected cells demonstrated that M1 delayed the appearance of late product of reverse transcription and HIV was blocked before its RNA expression. Conclusion The target of M 1 is post-integration of proviral DNA.
- Fungus extract,
- Anti-HIV-1 activity,
- PCR
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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In Vitro Anti-HIV Activity of a Chinese Fungus Extract

Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing 100094, China

National Center for AIDS/STD Control and Prevention (NCAIDS),Chinese Center for Disease Control and Prevention, Beijing 100050, China

Funds: 国家医药科学基金(2001BA705B01)%国家自然科学基金(30325047)

Key words:

Abstract: Objective To investigate the inhibitory effect of the mycelium extract from a Chinese fungus (M1) on HIV-1 and its mode of action. Methods Several in vitro methods including time of action, time of addition and PCR were used to test the mode of action of M1. Results M1 inhibited acute HIV infection in vitro and was effective when it was added 12 h after infection. PCR analysis of infected cells demonstrated that M1 delayed the appearance of late product of reverse transcription and HIV was blocked before its RNA expression. Conclusion The target of M 1 is post-integration of proviral DNA.

ZI-CHUN XIANG, YAN JIANG, SHUN-XING GUO. In Vitro Anti-HIV Activity of a Chinese Fungus Extract[J]. Biomedical and Environmental Sciences, 2006, 19(3): 169-172.

Citation:

ZI-CHUN XIANG, YAN JIANG, SHUN-XING GUO. In Vitro Anti-HIV Activity of a Chinese Fungus Extract[J]. Biomedical and Environmental Sciences, 2006, 19(3): 169-172.