FANG Guo Feng; FAN Xue Yun; SHEN Fu Hai

doi:10.3967/0895-3988.2011.06.013

The Relationship between Polymorphisms of Interleukin-4 Gene and Silicosis

文章导航 > Biomedical and Environmental Sciences > 2011 > 24(6): 678-682

FANG Guo Feng, FAN Xue Yun, SHEN Fu Hai. The Relationship between Polymorphisms of Interleukin-4 Gene and Silicosis[J]. Biomedical and Environmental Sciences, 2011, 24(6): 678-682. doi: 10.3967/0895-3988.2011.06.013

Citation:

FANG Guo Feng, FAN Xue Yun, SHEN Fu Hai. The Relationship between Polymorphisms of Interleukin-4 Gene and Silicosis[J]. Biomedical and Environmental Sciences, 2011, 24(6): 678-682. doi: 10.3967/0895-3988.2011.06.013

doi: 10.3967/0895-3988.2011.06.013

基金项目: the Science and Technology Department of Hebei Province(09276195D)

The Relationship between Polymorphisms of Interleukin-4 Gene and Silicosis

Department of Occupational and Environmental Health, School of Public Health, Hebei United University,Tangshan 063000, Hebei, China

Funds: the Science and Technology Department of Hebei Province(09276195D)

摘要: Objective To explore the relationship between polymorphisms of interleukin-4 (IL-4) gene (-33,+45,intron3,+429,+448) and the susceptibility of silicosis.Methods A case-control study was carried out.101 silicosis patients were selected as cases.As strictly matching,121 of non silicosis workers were selected as the controls.The polymophisms of IL-4 (five locus) were detected by the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques.Results The GA genotype in the IL-4+429 locus and the CC genotype in the IL-4+448 locus were found.The frequencies ofAA,GG and AG of IL-4+45 locus in the cases were 55.4％,10.9％,and 33.7％ and in the controls were 62.0％,11.6％,and 26.4％.The differences between cases and controls were not significant.The frequencies of B1B1,B2B2,and B1B2 of intron3 VNTR locus in the cases were 73.3％,1.0％,and 25.7％ and in the controls were 68.6％,1.7％,and 29.8％.The differences were not significant.The frequencies of TT,CC,and CT in -33 locus in the cases were 55.4％,11.9％,and 32.7％ and in the controls were 69.4％,4.1％,and 26.4％.The differences were significant (P=0.034).Conclusion The relationship between genetic polymorphism of IL-4-33 site and silicosis has been found and -33TT is a protective genotype for silicosis.
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Abstract: Objective To explore the relationship between polymorphisms of interleukin-4 (IL-4) gene (-33,+45,intron3,+429,+448) and the susceptibility of silicosis.Methods A case-control study was carried out.101 silicosis patients were selected as cases.As strictly matching,121 of non silicosis workers were selected as the controls.The polymophisms of IL-4 (five locus) were detected by the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques.Results The GA genotype in the IL-4+429 locus and the CC genotype in the IL-4+448 locus were found.The frequencies ofAA,GG and AG of IL-4+45 locus in the cases were 55.4％,10.9％,and 33.7％ and in the controls were 62.0％,11.6％,and 26.4％.The differences between cases and controls were not significant.The frequencies of B1B1,B2B2,and B1B2 of intron3 VNTR locus in the cases were 73.3％,1.0％,and 25.7％ and in the controls were 68.6％,1.7％,and 29.8％.The differences were not significant.The frequencies of TT,CC,and CT in -33 locus in the cases were 55.4％,11.9％,and 32.7％ and in the controls were 69.4％,4.1％,and 26.4％.The differences were significant (P=0.034).Conclusion The relationship between genetic polymorphism of IL-4-33 site and silicosis has been found and -33TT is a protective genotype for silicosis.
- Silicosis /
- Interleukin-4 /
- Polymorphism /
- Susceptibility

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The Relationship between Polymorphisms of Interleukin-4 Gene and Silicosis

doi: 10.3967/0895-3988.2011.06.013

基金项目: the Science and Technology Department of Hebei Province(09276195D)

刊出日期: 2011-12-20

关键词:

Silicosis /

Interleukin-4 /

Polymorphism /

Susceptibility

摘要: Objective To explore the relationship between polymorphisms of interleukin-4 (IL-4) gene (-33,+45,intron3,+429,+448) and the susceptibility of silicosis.Methods A case-control study was carried out.101 silicosis patients were selected as cases.As strictly matching,121 of non silicosis workers were selected as the controls.The polymophisms of IL-4 (five locus) were detected by the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques.Results The GA genotype in the IL-4+429 locus and the CC genotype in the IL-4+448 locus were found.The frequencies ofAA,GG and AG of IL-4+45 locus in the cases were 55.4％,10.9％,and 33.7％ and in the controls were 62.0％,11.6％,and 26.4％.The differences between cases and controls were not significant.The frequencies of B1B1,B2B2,and B1B2 of intron3 VNTR locus in the cases were 73.3％,1.0％,and 25.7％ and in the controls were 68.6％,1.7％,and 29.8％.The differences were not significant.The frequencies of TT,CC,and CT in -33 locus in the cases were 55.4％,11.9％,and 32.7％ and in the controls were 69.4％,4.1％,and 26.4％.The differences were significant (P=0.034).Conclusion The relationship between genetic polymorphism of IL-4-33 site and silicosis has been found and -33TT is a protective genotype for silicosis.

English Abstract

The Relationship between Polymorphisms of Interleukin-4 Gene and Silicosis

Department of Occupational and Environmental Health, School of Public Health, Hebei United University,Tangshan 063000, Hebei, China

Funds: the Science and Technology Department of Hebei Province(09276195D)

Publish Date: 2011-12-20

Keywords:

Abstract: Objective To explore the relationship between polymorphisms of interleukin-4 (IL-4) gene (-33,+45,intron3,+429,+448) and the susceptibility of silicosis.Methods A case-control study was carried out.101 silicosis patients were selected as cases.As strictly matching,121 of non silicosis workers were selected as the controls.The polymophisms of IL-4 (five locus) were detected by the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques.Results The GA genotype in the IL-4+429 locus and the CC genotype in the IL-4+448 locus were found.The frequencies ofAA,GG and AG of IL-4+45 locus in the cases were 55.4％,10.9％,and 33.7％ and in the controls were 62.0％,11.6％,and 26.4％.The differences between cases and controls were not significant.The frequencies of B1B1,B2B2,and B1B2 of intron3 VNTR locus in the cases were 73.3％,1.0％,and 25.7％ and in the controls were 68.6％,1.7％,and 29.8％.The differences were not significant.The frequencies of TT,CC,and CT in -33 locus in the cases were 55.4％,11.9％,and 32.7％ and in the controls were 69.4％,4.1％,and 26.4％.The differences were significant (P=0.034).Conclusion The relationship between genetic polymorphism of IL-4-33 site and silicosis has been found and -33TT is a protective genotype for silicosis.

Citation: