Volume 24 Issue 6
Dec.  2011
Turn off MathJax
Article Contents

FANG Guo Feng, FAN Xue Yun, SHEN Fu Hai. The Relationship between Polymorphisms of Interleukin-4 Gene and Silicosis[J]. Biomedical and Environmental Sciences, 2011, 24(6): 678-682. doi: 10.3967/0895-3988.2011.06.013
Citation: FANG Guo Feng, FAN Xue Yun, SHEN Fu Hai. The Relationship between Polymorphisms of Interleukin-4 Gene and Silicosis[J]. Biomedical and Environmental Sciences, 2011, 24(6): 678-682. doi: 10.3967/0895-3988.2011.06.013

The Relationship between Polymorphisms of Interleukin-4 Gene and Silicosis

doi: 10.3967/0895-3988.2011.06.013
Funds:  the Science and Technology Department of Hebei Province(09276195D)
  • Objective To explore the relationship between polymorphisms of interleukin-4 (IL-4) gene (-33,+45,intron3,+429,+448) and the susceptibility of silicosis.Methods A case-control study was carried out.101 silicosis patients were selected as cases.As strictly matching,121 of non silicosis workers were selected as the controls.The polymophisms of IL-4 (five locus) were detected by the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques.Results The GA genotype in the IL-4+429 locus and the CC genotype in the IL-4+448 locus were found.The frequencies ofAA,GG and AG of IL-4+45 locus in the cases were 55.4%,10.9%,and 33.7% and in the controls were 62.0%,11.6%,and 26.4%.The differences between cases and controls were not significant.The frequencies of B1B1,B2B2,and B1B2 of intron3 VNTR locus in the cases were 73.3%,1.0%,and 25.7% and in the controls were 68.6%,1.7%,and 29.8%.The differences were not significant.The frequencies of TT,CC,and CT in -33 locus in the cases were 55.4%,11.9%,and 32.7% and in the controls were 69.4%,4.1%,and 26.4%.The differences were significant (P=0.034).Conclusion The relationship between genetic polymorphism of IL-4-33 site and silicosis has been found and -33TT is a protective genotype for silicosis.
  • 加载中
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(1279) PDF downloads(26) Cited by()

Proportional views
Related

The Relationship between Polymorphisms of Interleukin-4 Gene and Silicosis

doi: 10.3967/0895-3988.2011.06.013
Funds:  the Science and Technology Department of Hebei Province(09276195D)

Abstract: Objective To explore the relationship between polymorphisms of interleukin-4 (IL-4) gene (-33,+45,intron3,+429,+448) and the susceptibility of silicosis.Methods A case-control study was carried out.101 silicosis patients were selected as cases.As strictly matching,121 of non silicosis workers were selected as the controls.The polymophisms of IL-4 (five locus) were detected by the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques.Results The GA genotype in the IL-4+429 locus and the CC genotype in the IL-4+448 locus were found.The frequencies ofAA,GG and AG of IL-4+45 locus in the cases were 55.4%,10.9%,and 33.7% and in the controls were 62.0%,11.6%,and 26.4%.The differences between cases and controls were not significant.The frequencies of B1B1,B2B2,and B1B2 of intron3 VNTR locus in the cases were 73.3%,1.0%,and 25.7% and in the controls were 68.6%,1.7%,and 29.8%.The differences were not significant.The frequencies of TT,CC,and CT in -33 locus in the cases were 55.4%,11.9%,and 32.7% and in the controls were 69.4%,4.1%,and 26.4%.The differences were significant (P=0.034).Conclusion The relationship between genetic polymorphism of IL-4-33 site and silicosis has been found and -33TT is a protective genotype for silicosis.

FANG Guo Feng, FAN Xue Yun, SHEN Fu Hai. The Relationship between Polymorphisms of Interleukin-4 Gene and Silicosis[J]. Biomedical and Environmental Sciences, 2011, 24(6): 678-682. doi: 10.3967/0895-3988.2011.06.013
Citation: FANG Guo Feng, FAN Xue Yun, SHEN Fu Hai. The Relationship between Polymorphisms of Interleukin-4 Gene and Silicosis[J]. Biomedical and Environmental Sciences, 2011, 24(6): 678-682. doi: 10.3967/0895-3988.2011.06.013

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return