Hyperinsulinemia, Insulin Resistance and Cognitive Decline in Older Cohort

ZHONG Yuan; MIAO Ya; JIA Wei Ping; YAN Hong; WANG Bei Yun; JIN Jun

doi:10.3967/0895-3988.2012.01.002

PDF
Cite
Share

facebook

twitter

google

linkedin

Volume 25 Issue 1

Feb. 2012

Turn off MathJax

Article Contents

Article Navigation > Biomedical and Environmental Sciences > 2012 > 25(1): 8-14

ZHONG Yuan, MIAO Ya, JIA Wei Ping, YAN Hong, WANG Bei Yun, JIN Jun. Hyperinsulinemia, Insulin Resistance and Cognitive Decline in Older Cohort[J]. Biomedical and Environmental Sciences, 2012, 25(1): 8-14. doi: 10.3967/0895-3988.2012.01.002

Citation:

ZHONG Yuan, MIAO Ya, JIA Wei Ping, YAN Hong, WANG Bei Yun, JIN Jun. Hyperinsulinemia, Insulin Resistance and Cognitive Decline in Older Cohort[J]. Biomedical and Environmental Sciences, 2012, 25(1): 8-14. doi: 10.3967/0895-3988.2012.01.002

Hyperinsulinemia, Insulin Resistance and Cognitive Decline in Older Cohort

doi: 10.3967/0895-3988.2012.01.002

Department of Geriatrics, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233,China
Department of Endocrinology and Metabolism, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai Diabetes Institute, Shanghai 200233, China

Funds: This study was supported by the Medical College Natural Science Foundation of Shanghai Jiao Tong University(09XJ21028)%the Shanghai Jiaotong University Interdisciplinary Study Foundation Medicine and Engineer

Abstract

Objective Type 2 diabetes has been recently recognized as an important risk factor for cognitive decline of patients with Alzheimer's disease (AD).But the roles of hyperinsulinemia (HI) and insulin resistance (IR) in the development of AD are still controversial.This study was designed to evaluate whether HI or IR influenced the cognitive functions of older cohort.Methods The cognitive functions of 328 consecutive elderly patients were evaluated with a battery of cognitive rating scales.Their fasting blood glucose (FBG) and fasting insulin (FINS) were analyzed and IR was calculated with modified-Homa.The cognitive scores in different groups and the correlation of cognitive functions with HI or IR were analyzed.Results In our study,there were 180 participants with HI and 148 without HI,and 192 with IR and 136 without IR.The participants with HI showed worse cognitive functions than those without HI in MMSE,MOCA,CDR,orientation,delayed memory,and attention/calculation domains.Similarly,the elderly with IR had lower cognitive scores than those without IR in MMSE,MOCA,CDR,GDS,orientation,delayed memory,and attention/calculation domains.The insulin levels and Homa IR had negative correlation with the scores of MMSE and delayed memory,not only in the model 1 adjusted for FBG and diabetes history,but also in the model 2 adjusted for all nine demographic characteristics.Conclusion HI and IR are important risk factors for cognitive decline of the elderly,especially for the dysfunctions in delayed memory domains.
- Cognitive function,
- Alzheimer's disease,
- Hyperinsulinemia,
- Insulin resistance
References
Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views(1693) PDF downloads(65) Cited by()

Proportional views

Hyperinsulinemia, Insulin Resistance and Cognitive Decline in Older Cohort

doi: 10.3967/0895-3988.2012.01.002

Department of Geriatrics, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233,China

Department of Endocrinology and Metabolism, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai Diabetes Institute, Shanghai 200233, China

Key words:

Abstract: Objective Type 2 diabetes has been recently recognized as an important risk factor for cognitive decline of patients with Alzheimer's disease (AD).But the roles of hyperinsulinemia (HI) and insulin resistance (IR) in the development of AD are still controversial.This study was designed to evaluate whether HI or IR influenced the cognitive functions of older cohort.Methods The cognitive functions of 328 consecutive elderly patients were evaluated with a battery of cognitive rating scales.Their fasting blood glucose (FBG) and fasting insulin (FINS) were analyzed and IR was calculated with modified-Homa.The cognitive scores in different groups and the correlation of cognitive functions with HI or IR were analyzed.Results In our study,there were 180 participants with HI and 148 without HI,and 192 with IR and 136 without IR.The participants with HI showed worse cognitive functions than those without HI in MMSE,MOCA,CDR,orientation,delayed memory,and attention/calculation domains.Similarly,the elderly with IR had lower cognitive scores than those without IR in MMSE,MOCA,CDR,GDS,orientation,delayed memory,and attention/calculation domains.The insulin levels and Homa IR had negative correlation with the scores of MMSE and delayed memory,not only in the model 1 adjusted for FBG and diabetes history,but also in the model 2 adjusted for all nine demographic characteristics.Conclusion HI and IR are important risk factors for cognitive decline of the elderly,especially for the dysfunctions in delayed memory domains.

Citation: