Volume 25 Issue 5
Oct.  2012
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LI Kui, LIANG Yu, SUN Yin, ZHANG Ling Xia, YI Xin, CHEN Yong, GU SANG LA MU, WANG Jian. The Relationship between Polymorphisms at 17 Gene Sites and Hypertension among the Aboriginal Tibetan People[J]. Biomedical and Environmental Sciences, 2012, 25(5): 526-532. doi: 10.3967/0895-3988.2012.05.005
Citation: LI Kui, LIANG Yu, SUN Yin, ZHANG Ling Xia, YI Xin, CHEN Yong, GU SANG LA MU, WANG Jian. The Relationship between Polymorphisms at 17 Gene Sites and Hypertension among the Aboriginal Tibetan People[J]. Biomedical and Environmental Sciences, 2012, 25(5): 526-532. doi: 10.3967/0895-3988.2012.05.005

The Relationship between Polymorphisms at 17 Gene Sites and Hypertension among the Aboriginal Tibetan People

doi: 10.3967/0895-3988.2012.05.005
Funds:  the Chinese Ministry of Science and Technology (973 Program)(2006CB504103)%Chinese Academy of Sciences(KSCX2‐YW‐R‐76)%Science and Technology Plan of the Tibet Autonomous Region(2007‐2‐18)
  • Objective The incidence of hypertension in Tibet ranks highest among all Chinese provinces. This may be due to genetic changes caused by Tibet's unique natural environment and agrarian lifestyle, prompting us to investigated the relationship between gene polymorphisms and hypertension. Methods Blood samples were collected from 229 hypertensive participants and 372 healthy (control) participants from five Tibetan counties. Seventeen single nucleotide polymorphisms were investigated for their connection to hypertension. Results The C allele at rs2070744 of the NOS3 gene was shown to be significantly associated with hypertension (P=0.0443; OR=1.636). Additionally, the T allele of rs4961 of the ADD gene was correlated with hypertension in women (P=0.03124; OR=1.584). Conclusion In this study we found that the NOS3 and ADD genes were related to a high incidence of hypertension among Tibetans. NOS3 gene plays a role in regulating vascular tone and blood vessel diameter, which may be altered by the low‐oxygen environment of Tibet. ADD is involved in water and salt metabolism, which is consistent with the high‐salt diet of Tibetans. The correlations elucidated by our study were different from those of other ethnic groups, indicating that these findings may be specific to the Tibetan people.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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The Relationship between Polymorphisms at 17 Gene Sites and Hypertension among the Aboriginal Tibetan People

doi: 10.3967/0895-3988.2012.05.005
Funds:  the Chinese Ministry of Science and Technology (973 Program)(2006CB504103)%Chinese Academy of Sciences(KSCX2‐YW‐R‐76)%Science and Technology Plan of the Tibet Autonomous Region(2007‐2‐18)

Abstract: Objective The incidence of hypertension in Tibet ranks highest among all Chinese provinces. This may be due to genetic changes caused by Tibet's unique natural environment and agrarian lifestyle, prompting us to investigated the relationship between gene polymorphisms and hypertension. Methods Blood samples were collected from 229 hypertensive participants and 372 healthy (control) participants from five Tibetan counties. Seventeen single nucleotide polymorphisms were investigated for their connection to hypertension. Results The C allele at rs2070744 of the NOS3 gene was shown to be significantly associated with hypertension (P=0.0443; OR=1.636). Additionally, the T allele of rs4961 of the ADD gene was correlated with hypertension in women (P=0.03124; OR=1.584). Conclusion In this study we found that the NOS3 and ADD genes were related to a high incidence of hypertension among Tibetans. NOS3 gene plays a role in regulating vascular tone and blood vessel diameter, which may be altered by the low‐oxygen environment of Tibet. ADD is involved in water and salt metabolism, which is consistent with the high‐salt diet of Tibetans. The correlations elucidated by our study were different from those of other ethnic groups, indicating that these findings may be specific to the Tibetan people.

LI Kui, LIANG Yu, SUN Yin, ZHANG Ling Xia, YI Xin, CHEN Yong, GU SANG LA MU, WANG Jian. The Relationship between Polymorphisms at 17 Gene Sites and Hypertension among the Aboriginal Tibetan People[J]. Biomedical and Environmental Sciences, 2012, 25(5): 526-532. doi: 10.3967/0895-3988.2012.05.005
Citation: LI Kui, LIANG Yu, SUN Yin, ZHANG Ling Xia, YI Xin, CHEN Yong, GU SANG LA MU, WANG Jian. The Relationship between Polymorphisms at 17 Gene Sites and Hypertension among the Aboriginal Tibetan People[J]. Biomedical and Environmental Sciences, 2012, 25(5): 526-532. doi: 10.3967/0895-3988.2012.05.005

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