Volume 25 Issue 5
Oct.  2012
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ZHU Xiao Hong, JIAO Yang, LI Hong Mei, WANG Ai Li, WANG Gui Yan, TONG Wei Jun, ZHANG Yong Hong. Clustering of Inflammatory Biomarkers and Risk of Hypertension in a Mongolian Population in China[J]. Biomedical and Environmental Sciences, 2012, 25(5): 562-568. doi: 10.3967/0895-3988.2012.05.010
Citation: ZHU Xiao Hong, JIAO Yang, LI Hong Mei, WANG Ai Li, WANG Gui Yan, TONG Wei Jun, ZHANG Yong Hong. Clustering of Inflammatory Biomarkers and Risk of Hypertension in a Mongolian Population in China[J]. Biomedical and Environmental Sciences, 2012, 25(5): 562-568. doi: 10.3967/0895-3988.2012.05.010

Clustering of Inflammatory Biomarkers and Risk of Hypertension in a Mongolian Population in China

doi: 10.3967/0895-3988.2012.05.010
Funds:  the National Natural Science Foundation of China(30972531)%Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions
  • Objective There is little knowledge on whether there is clustering of inflammatory biomarkers, such as C‐reactive protein (CRP), soluble intracellular adhesion molecule1‐1 (sICAM‐1), and angiotensin II (Ang II), in individuals with hypertension in the Mongolian population. In the present study, we investigated this relationship in a Mongolian population in China. Methods A total of 2589 adult Mongolians, aged 20 years and older, were recruited as study participants. Data on demographics, lifestyle, family history of hypertension, blood pressure, and blood chemistry were collected, and inflammatory biomarkers were measured in all participants.Results The proportion of subjects with increased levels of two or three biomarkers was significantly higher in those with hypertension (21.0% and 6.0%, respectively) than in those with prehypertension (12.7% and 0.5%, respectively) or normotension (8.1% and 0.2%, respectively). The multivariate adjusted odds ratios (95% confidence interval) of hypertension associated with increased levels of one,two or three biomarkers were 0.94 (0.72‐1.22), 1.42 (0.93‐2.16), and 11.08 (1.45‐84.80), respectively, compared with subjects with no increase in any biomarker.Conclusion Hypertension was associated with a cluster of inflammatory biomarkers in the Mongolian population.
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Clustering of Inflammatory Biomarkers and Risk of Hypertension in a Mongolian Population in China

doi: 10.3967/0895-3988.2012.05.010
Funds:  the National Natural Science Foundation of China(30972531)%Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions

Abstract: Objective There is little knowledge on whether there is clustering of inflammatory biomarkers, such as C‐reactive protein (CRP), soluble intracellular adhesion molecule1‐1 (sICAM‐1), and angiotensin II (Ang II), in individuals with hypertension in the Mongolian population. In the present study, we investigated this relationship in a Mongolian population in China. Methods A total of 2589 adult Mongolians, aged 20 years and older, were recruited as study participants. Data on demographics, lifestyle, family history of hypertension, blood pressure, and blood chemistry were collected, and inflammatory biomarkers were measured in all participants.Results The proportion of subjects with increased levels of two or three biomarkers was significantly higher in those with hypertension (21.0% and 6.0%, respectively) than in those with prehypertension (12.7% and 0.5%, respectively) or normotension (8.1% and 0.2%, respectively). The multivariate adjusted odds ratios (95% confidence interval) of hypertension associated with increased levels of one,two or three biomarkers were 0.94 (0.72‐1.22), 1.42 (0.93‐2.16), and 11.08 (1.45‐84.80), respectively, compared with subjects with no increase in any biomarker.Conclusion Hypertension was associated with a cluster of inflammatory biomarkers in the Mongolian population.

ZHU Xiao Hong, JIAO Yang, LI Hong Mei, WANG Ai Li, WANG Gui Yan, TONG Wei Jun, ZHANG Yong Hong. Clustering of Inflammatory Biomarkers and Risk of Hypertension in a Mongolian Population in China[J]. Biomedical and Environmental Sciences, 2012, 25(5): 562-568. doi: 10.3967/0895-3988.2012.05.010
Citation: ZHU Xiao Hong, JIAO Yang, LI Hong Mei, WANG Ai Li, WANG Gui Yan, TONG Wei Jun, ZHANG Yong Hong. Clustering of Inflammatory Biomarkers and Risk of Hypertension in a Mongolian Population in China[J]. Biomedical and Environmental Sciences, 2012, 25(5): 562-568. doi: 10.3967/0895-3988.2012.05.010

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