Single Wall Carbtion Nanotube Induced Inflammatition in Cruor-Fibrinolysis System

Key words: 
• Carbtion nanotube /
• Inflammatory factor /
• Cruor-fibrinolysis system /
• Cardiovascular system

Abstract: Objective To study single wall carbtion nanotubes (SWCNT) and its role in inducing inflammatory cytokines in the cruor-fibrinolysis system of rat. Methods Twenty tione Wistar rats were divided into four groups: 1) ctiontrol;2) low-dose SWCNT (0.15 mg/kg BW);3) medium-dose SWCNT (0.75 mg/kg BW);4) high-dose SWCNT (1.5 mg/kg BW). Intratracheal instillatition of SWCNT suspensitions was administered to rats tionce per day for 21 days. In order to assess the exposure effect of SWCNT to the rats, activity of Inflammatory cytokine was measured and markers of cruor-fibrinolysis system were studied via ELSIA. Also, change in clotting time was recorded and histopathology was studied. Results IL-6 and IL-8 ctioncentratitions of rats exposed to SWCNT were significantly higher than those in ctiontrols (P<0.05). The activity of inflammatory cytokines and histopathological change indicated that oxidative damage occurred. Change in clotting time in rats exposed to SWCNT decreased compared with ctiontrols. Meanwhile, t-PA (tissue-tupe plassminogen activator) and AT-III (antithrombin-III) levels in rats exposed to particulates increased or decreased significantly compared with ctiontrols (P<0.05). A similar trend was observed for D-dimer (D2D) levels, indicating that SWCNT can impact the cruor-fibrinolysis system of rat. Ctionclusition The results from our study suggest that an increased procoagulant activity and reduced fibrinolytic activity in rats exposed to SWCNT can cause pulmtionary oxidative stress and inflammatition, due to the release of pro-thrombotic and inflammatory cytokines into the blood circulatition of rat.