Volume 27 Issue 2
Feb.  2014
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Daniela-Saveta POPA, Pompei BOLFA, Bela KISS, Laurian VLASE, Ramona P?LTINEAN, Anca POP, Cornel CTOI, Gianina CRIAN, Felicia LOGHIN. Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats[J]. Biomedical and Environmental Sciences, 2014, 27(2): 85-96. doi: 10.3967/bes2014.021
Citation: Daniela-Saveta POPA, Pompei BOLFA, Bela KISS, Laurian VLASE, Ramona P?LTINEAN, Anca POP, Cornel CTOI, Gianina CRIAN, Felicia LOGHIN. Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats[J]. Biomedical and Environmental Sciences, 2014, 27(2): 85-96. doi: 10.3967/bes2014.021

Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats

doi: 10.3967/bes2014.021
  • ObjectiveTo evaluate the influence of an extract ofGenista tinctoria L. herba (GT) or methylparaben (MP) on histopathological changes and2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A (BPA).
    MethodsAdult female Wistar rats were orally exposed for 90 d to BPA (50 mg/kg), BPA+GT (35 mg isoflavones/kg) or BPA+MP (250 mg/kg). Plasma and tissue samples weretaken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation andin vivo hydroxyl radical production were evaluated byhistological analysis along withmalondialdehyde and 2,3-dihydroxybenzoic aciddetection.
    ResultsTheseverity of histopathological changes in liver and kidneyswas lower afterGT treatmentthan afterBPA or BPA+MPtreatment. A minimal thyroid receptor antagonist effect was only observedafter BPA+MPtreatment.Theabnormal folliculogenesis increased in a time-dependent manner,and the number of corpus luteum decreased.No significant histological alterationswere foundin the uterus.The mammary gland displayed specific estrogen stimulation changes at all periods. Both MP and GT revealed antioxidant properties reducing lipid peroxidation and BPA-inducedhydroxyl radical generation.
    ConclusionGTL. extract ameliorates the toxic effects of BPA andisprovedto haveantioxidant potential and antitoxic effect. MP has antioxidant properties, but has either no effect or exacerbates the BPA-induced histopathological changes.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats

doi: 10.3967/bes2014.021

Abstract: ObjectiveTo evaluate the influence of an extract ofGenista tinctoria L. herba (GT) or methylparaben (MP) on histopathological changes and2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A (BPA).
MethodsAdult female Wistar rats were orally exposed for 90 d to BPA (50 mg/kg), BPA+GT (35 mg isoflavones/kg) or BPA+MP (250 mg/kg). Plasma and tissue samples weretaken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation andin vivo hydroxyl radical production were evaluated byhistological analysis along withmalondialdehyde and 2,3-dihydroxybenzoic aciddetection.
ResultsTheseverity of histopathological changes in liver and kidneyswas lower afterGT treatmentthan afterBPA or BPA+MPtreatment. A minimal thyroid receptor antagonist effect was only observedafter BPA+MPtreatment.Theabnormal folliculogenesis increased in a time-dependent manner,and the number of corpus luteum decreased.No significant histological alterationswere foundin the uterus.The mammary gland displayed specific estrogen stimulation changes at all periods. Both MP and GT revealed antioxidant properties reducing lipid peroxidation and BPA-inducedhydroxyl radical generation.
ConclusionGTL. extract ameliorates the toxic effects of BPA andisprovedto haveantioxidant potential and antitoxic effect. MP has antioxidant properties, but has either no effect or exacerbates the BPA-induced histopathological changes.

Daniela-Saveta POPA, Pompei BOLFA, Bela KISS, Laurian VLASE, Ramona P?LTINEAN, Anca POP, Cornel CTOI, Gianina CRIAN, Felicia LOGHIN. Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats[J]. Biomedical and Environmental Sciences, 2014, 27(2): 85-96. doi: 10.3967/bes2014.021
Citation: Daniela-Saveta POPA, Pompei BOLFA, Bela KISS, Laurian VLASE, Ramona P?LTINEAN, Anca POP, Cornel CTOI, Gianina CRIAN, Felicia LOGHIN. Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats[J]. Biomedical and Environmental Sciences, 2014, 27(2): 85-96. doi: 10.3967/bes2014.021

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