Dyslipidemia and Outcome in Patients with Acute Ischemic Stroke
doi: 10.3967/bes2014.023
Funds:
This study was supported by the National Natural Science Foundation ofChina(Grant 81172761)%a Project of the PriorityAcademic Program Development of Jiangsu Higher Education Institutions
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Key words:
- Dyslipidemia /
- Acute ischemic stroke /
- Outcome /
- Multivariate logistic regression analysis /
- Propensity score-adjusted analysis
Abstract: ObjectiveTo study the relationship between dyslipidemia and outcome in patients with acute ischemic stroke.
MethodsData about 1 568 patients with acute ischemic stroke werecollected from 4 hospitals in Shandong Province from January 2006 to December 2008. National Institute of Health Stroke Scale (NIHSS) >10 at discharge or death was defined as the outcome. Effect of dyslipidemia on outcome in patients with acute ischemic stroke was analyzed by multivariate logistic regression analysis and propensity score-adjusted analysis, respectively.
ResultsThe serum levels of TC, LDL-C, and HDL-C were significantly associated with the outcome in patients with acute ischemic stroke. Multivariate logistic regression analysis and propensity score-adjusted analysis showed that the ORs and 95% CIs were 3.013 (1.259, 7.214)/2.655 (1.298, 5.43), 3.157(1.306, 7.631)/3.405(1.621, 7.154), and 0.482 (0.245, 0.946)/0.51 (0.282, 0.921), respectively, for patients with acute ischemic stroke. Hosmer-Lemeshow goodness-of-fit test showed no significant difference in observed and predicted risk in patients with acute ischemic stroke (chi-square=8.235, P=0.411).
ConclusionSerum levels of TC, LDL-C, and HDL-C are positively related with the outcome in patients with acute ischemic stroke.
| Citation: | XU Tian, ZHANG Jin Tao, YANG Mei, ZHANG Huan, LIU Wen Qing, KONG Yan, XU Tan, ZHANG Yong Hong. Dyslipidemia and Outcome in Patients with Acute Ischemic Stroke[J]. Biomedical and Environmental Sciences, 2014, 27(2): 106-110. doi: 10.3967/bes2014.023
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