Volume 27 Issue 2
Feb.  2014
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XU Tian, ZHANG Jin Tao, YANG Mei, ZHANG Huan, LIU Wen Qing, KONG Yan, XU Tan, ZHANG Yong Hong. Dyslipidemia and Outcome in Patients with Acute Ischemic Stroke[J]. Biomedical and Environmental Sciences, 2014, 27(2): 106-110. doi: 10.3967/bes2014.023
Citation: XU Tian, ZHANG Jin Tao, YANG Mei, ZHANG Huan, LIU Wen Qing, KONG Yan, XU Tan, ZHANG Yong Hong. Dyslipidemia and Outcome in Patients with Acute Ischemic Stroke[J]. Biomedical and Environmental Sciences, 2014, 27(2): 106-110. doi: 10.3967/bes2014.023

Dyslipidemia and Outcome in Patients with Acute Ischemic Stroke

doi: 10.3967/bes2014.023
Funds:  This study was supported by the National Natural Science Foundation ofChina(Grant 81172761)%a Project of the PriorityAcademic Program Development of Jiangsu Higher Education Institutions
  • ObjectiveTo study the relationship between dyslipidemia and outcome in patients with acute ischemic stroke.
    MethodsData about 1 568 patients with acute ischemic stroke werecollected from 4 hospitals in Shandong Province from January 2006 to December 2008. National Institute of Health Stroke Scale (NIHSS) >10 at discharge or death was defined as the outcome. Effect of dyslipidemia on outcome in patients with acute ischemic stroke was analyzed by multivariate logistic regression analysis and propensity score-adjusted analysis, respectively.
    ResultsThe serum levels of TC, LDL-C, and HDL-C were significantly associated with the outcome in patients with acute ischemic stroke. Multivariate logistic regression analysis and propensity score-adjusted analysis showed that the ORs and 95% CIs were 3.013 (1.259, 7.214)/2.655 (1.298, 5.43), 3.157(1.306, 7.631)/3.405(1.621, 7.154), and 0.482 (0.245, 0.946)/0.51 (0.282, 0.921), respectively, for patients with acute ischemic stroke. Hosmer-Lemeshow goodness-of-fit test showed no significant difference in observed and predicted risk in patients with acute ischemic stroke (chi-square=8.235, P=0.411).
    ConclusionSerum levels of TC, LDL-C, and HDL-C are positively related with the outcome in patients with acute ischemic stroke.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Dyslipidemia and Outcome in Patients with Acute Ischemic Stroke

doi: 10.3967/bes2014.023
Funds:  This study was supported by the National Natural Science Foundation ofChina(Grant 81172761)%a Project of the PriorityAcademic Program Development of Jiangsu Higher Education Institutions

Abstract: ObjectiveTo study the relationship between dyslipidemia and outcome in patients with acute ischemic stroke.
MethodsData about 1 568 patients with acute ischemic stroke werecollected from 4 hospitals in Shandong Province from January 2006 to December 2008. National Institute of Health Stroke Scale (NIHSS) >10 at discharge or death was defined as the outcome. Effect of dyslipidemia on outcome in patients with acute ischemic stroke was analyzed by multivariate logistic regression analysis and propensity score-adjusted analysis, respectively.
ResultsThe serum levels of TC, LDL-C, and HDL-C were significantly associated with the outcome in patients with acute ischemic stroke. Multivariate logistic regression analysis and propensity score-adjusted analysis showed that the ORs and 95% CIs were 3.013 (1.259, 7.214)/2.655 (1.298, 5.43), 3.157(1.306, 7.631)/3.405(1.621, 7.154), and 0.482 (0.245, 0.946)/0.51 (0.282, 0.921), respectively, for patients with acute ischemic stroke. Hosmer-Lemeshow goodness-of-fit test showed no significant difference in observed and predicted risk in patients with acute ischemic stroke (chi-square=8.235, P=0.411).
ConclusionSerum levels of TC, LDL-C, and HDL-C are positively related with the outcome in patients with acute ischemic stroke.

XU Tian, ZHANG Jin Tao, YANG Mei, ZHANG Huan, LIU Wen Qing, KONG Yan, XU Tan, ZHANG Yong Hong. Dyslipidemia and Outcome in Patients with Acute Ischemic Stroke[J]. Biomedical and Environmental Sciences, 2014, 27(2): 106-110. doi: 10.3967/bes2014.023
Citation: XU Tian, ZHANG Jin Tao, YANG Mei, ZHANG Huan, LIU Wen Qing, KONG Yan, XU Tan, ZHANG Yong Hong. Dyslipidemia and Outcome in Patients with Acute Ischemic Stroke[J]. Biomedical and Environmental Sciences, 2014, 27(2): 106-110. doi: 10.3967/bes2014.023

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