Application of Gas Chromatography-mass Spectrometry in Analyzing Pharmacokinetics and Distribution of Deltamethrin in Miniature Pig Tissues

ZHU Pan; FAN Sai; ZOU Jian Hong; MIAO Hong; LI Jing Guang; ZHANG Guo Wen; WU Yong Ning

doi:10.3967/bes2014.035

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Volume 27 Issue 6

Jun. 2014

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Article Navigation > Biomedical and Environmental Sciences > 2014 > 27(6): 426-435

ZHU Pan, FAN Sai, ZOU Jian Hong, MIAO Hong, LI Jing Guang, ZHANG Guo Wen, WU Yong Ning. Application of Gas Chromatography-mass Spectrometry in Analyzing Pharmacokinetics and Distribution of Deltamethrin in Miniature Pig Tissues[J]. Biomedical and Environmental Sciences, 2014, 27(6): 426-435. doi: 10.3967/bes2014.035

Citation:

ZHU Pan, FAN Sai, ZOU Jian Hong, MIAO Hong, LI Jing Guang, ZHANG Guo Wen, WU Yong Ning. Application of Gas Chromatography-mass Spectrometry in Analyzing Pharmacokinetics and Distribution of Deltamethrin in Miniature Pig Tissues[J]. Biomedical and Environmental Sciences, 2014, 27(6): 426-435. doi: 10.3967/bes2014.035

Application of Gas Chromatography-mass Spectrometry in Analyzing Pharmacokinetics and Distribution of Deltamethrin in Miniature Pig Tissues

doi: 10.3967/bes2014.035

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China
Institute of Nutrition and Food Safety, Beijing Centre of Disease Control and Prevention, Beijing 100013, China
The Second Artillery General Hospital, Beijing 100088, China
Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China

Funds: the National Natural Science Foundation of China, No.30700664 and No.2012CB720804

Abstract

Objective To characterize the pharmacokinetics and distribution profiles of deltamethrin in miniature pig tissues by gas chromatography-mass spectrometry (GC-MS).
Methods Pharmacokinetics and distribution of deltamethrin in blood and tissues of 30 miniature pigs were studied by GC-MS after oral administration of deltamethrin (5 mg/kg bw). Data were processed by 3P97 software.
Results The serum deltamethrin level was significantly lower in tissues than in blood of miniature pigs. The AUC0-72 h, Cmax, of deltamethrin were 555.330±316.987 ng h/mL and 17.861±11.129 ng/mL, respectively. The Tmax, of deltamethrin was 6.004±3.131 h.
Conclusion The metabolism of deltamethrin in miniature pigs is fit for a one-compartment model with a weighting function of 1/C2. Deltamethrin is rapidly hydrolyzed and accumulated in miniature pig tissues.
- Deltamethrin,
- Miniature pig,
- Pharmacokinetics,
- Tissue distribution,
- GC-MS
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Application of Gas Chromatography-mass Spectrometry in Analyzing Pharmacokinetics and Distribution of Deltamethrin in Miniature Pig Tissues

doi: 10.3967/bes2014.035

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China

Institute of Nutrition and Food Safety, Beijing Centre of Disease Control and Prevention, Beijing 100013, China

The Second Artillery General Hospital, Beijing 100088, China

Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China

Funds: the National Natural Science Foundation of China, No.30700664 and No.2012CB720804

Key words:

Abstract: Objective To characterize the pharmacokinetics and distribution profiles of deltamethrin in miniature pig tissues by gas chromatography-mass spectrometry (GC-MS).
Methods Pharmacokinetics and distribution of deltamethrin in blood and tissues of 30 miniature pigs were studied by GC-MS after oral administration of deltamethrin (5 mg/kg bw). Data were processed by 3P97 software.
Results The serum deltamethrin level was significantly lower in tissues than in blood of miniature pigs. The AUC0-72 h, Cmax, of deltamethrin were 555.330±316.987 ng h/mL and 17.861±11.129 ng/mL, respectively. The Tmax, of deltamethrin was 6.004±3.131 h.
Conclusion The metabolism of deltamethrin in miniature pigs is fit for a one-compartment model with a weighting function of 1/C2. Deltamethrin is rapidly hydrolyzed and accumulated in miniature pig tissues.

Citation:

ZHU Pan, FAN Sai, ZOU Jian Hong, MIAO Hong, LI Jing Guang, ZHANG Guo Wen, WU Yong Ning. Application of Gas Chromatography-mass Spectrometry in Analyzing Pharmacokinetics and Distribution of Deltamethrin in Miniature Pig Tissues[J]. Biomedical and Environmental Sciences, 2014, 27(6): 426-435. doi: 10.3967/bes2014.035