Volume 29 Issue 8
Aug.  2016
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KONG YanHua, SHI Qi, ZHANG Ling, ZHANG YuanYuan, GAO TongXin, CHENChen, LIYouLin. Structural Modulation of Gut Microbiota in Rats with Allergic Bronchial Asthma Treated with Recuperating Lung Decoction[J]. Biomedical and Environmental Sciences, 2016, 29(8): 574-583. doi: 10.3967/bes2016.076
Citation: KONG YanHua, SHI Qi, ZHANG Ling, ZHANG YuanYuan, GAO TongXin, CHENChen, LIYouLin. Structural Modulation of Gut Microbiota in Rats with Allergic Bronchial Asthma Treated with Recuperating Lung Decoction[J]. Biomedical and Environmental Sciences, 2016, 29(8): 574-583. doi: 10.3967/bes2016.076

Structural Modulation of Gut Microbiota in Rats with Allergic Bronchial Asthma Treated with Recuperating Lung Decoction

doi: 10.3967/bes2016.076
Funds:  This study was supported byYoung Scientists Fund of National Science Foundation of China(81302943, 81302941)%This was a project aimed at promoting the talents of young scientists in 2015(2015-QNYC-A-01)
  • ObjectiveTo investigate whether recuperating lung decoction (RLD) can modulate the composition of gut microbiota in rats during asthma treatment. MethodsFifteen Sprague-Dawley rats were divided randomly and equally into control group, model group, dexamethasone (DEX) group, RLD medium-dose group, and RLD high-dose group. The asthma model was established in all groups, except for the control group. The rats in the DEX and RLD groups were treated orally with DEX and RLD, respectively. The rats in the control and model groups were treated orally with 0.9% saline. The intestinal bacterial communities were compared among groups using 16S rRNA gene amplification and 454 pyrosequencing. ResultsThe microbial flora differed between the control and model groups, but the flora in the RLD groups was similar to that in the control group. No significant differences were observed between the RLD high-dose and medium-dose groups. RLD treatment resulted in an increase in the level beneficial bacteria in the gut, such asLactobacillusandBifidobacteriumspp. ConclusionOral administration of RLD increased the number of intestinal lactic acid-producing bacteria, such as Lactobacillus andBifidobacterium, in asthma model rats.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Structural Modulation of Gut Microbiota in Rats with Allergic Bronchial Asthma Treated with Recuperating Lung Decoction

doi: 10.3967/bes2016.076
Funds:  This study was supported byYoung Scientists Fund of National Science Foundation of China(81302943, 81302941)%This was a project aimed at promoting the talents of young scientists in 2015(2015-QNYC-A-01)

Abstract: ObjectiveTo investigate whether recuperating lung decoction (RLD) can modulate the composition of gut microbiota in rats during asthma treatment. MethodsFifteen Sprague-Dawley rats were divided randomly and equally into control group, model group, dexamethasone (DEX) group, RLD medium-dose group, and RLD high-dose group. The asthma model was established in all groups, except for the control group. The rats in the DEX and RLD groups were treated orally with DEX and RLD, respectively. The rats in the control and model groups were treated orally with 0.9% saline. The intestinal bacterial communities were compared among groups using 16S rRNA gene amplification and 454 pyrosequencing. ResultsThe microbial flora differed between the control and model groups, but the flora in the RLD groups was similar to that in the control group. No significant differences were observed between the RLD high-dose and medium-dose groups. RLD treatment resulted in an increase in the level beneficial bacteria in the gut, such asLactobacillusandBifidobacteriumspp. ConclusionOral administration of RLD increased the number of intestinal lactic acid-producing bacteria, such as Lactobacillus andBifidobacterium, in asthma model rats.

KONG YanHua, SHI Qi, ZHANG Ling, ZHANG YuanYuan, GAO TongXin, CHENChen, LIYouLin. Structural Modulation of Gut Microbiota in Rats with Allergic Bronchial Asthma Treated with Recuperating Lung Decoction[J]. Biomedical and Environmental Sciences, 2016, 29(8): 574-583. doi: 10.3967/bes2016.076
Citation: KONG YanHua, SHI Qi, ZHANG Ling, ZHANG YuanYuan, GAO TongXin, CHENChen, LIYouLin. Structural Modulation of Gut Microbiota in Rats with Allergic Bronchial Asthma Treated with Recuperating Lung Decoction[J]. Biomedical and Environmental Sciences, 2016, 29(8): 574-583. doi: 10.3967/bes2016.076

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